Lupus: Molecular and Cellular Pathogenesis

Front Matter....Pages i-xx
Lupus....Pages 1-12
The Vascular Endothelium....Pages 13-20
Nitric Oxide in Systemic Lupus Erythematosus....Pages 21-42
Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus....Pages 43-64
Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells....Pages 65-78
Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus....Pages 79-100
Genetics of Systemic Lupus Erythematosus....Pages 101-123
Genetic Insights into Murine Lupus....Pages 124-139
Murine Graft-vs-Host Disease....Pages 140-151
Lessons from Knockout and Transgenic Lupus-Prone Mice....Pages 152-166
B Cells in Systemic Lupus Erythematosus....Pages 167-180
Mechanisms of the Pathogenic Autoimmune Response in Lupus....Pages 181-201
T Cell Autoimmunity in Lupus....Pages 202-219
T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosus Models....Pages 220-230
Mechanisms of T-Helper Cell Activation and Function in Systemic Lupus Erythematosus....Pages 231-256
A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes....Pages 257-277
Impaired DNA Methylation in Lupus T Cells....Pages 278-298
Impaired Non-Antigen-Specific T-Cell Cytolytic Activity in SLE....Pages 299-311
Natural Killer Cells and CD8 + T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE....Pages 312-320
Cytokines in the Immunopathogenesis of Lupus....Pages 321-340
Cytokine Gene Expression in Human Systemic Lupus Erythematosus....Pages 341-360
Balance Between Type 1 and Type 2 Cytokine-Secreting Cells....Pages 361-370
Autoantibodies as a Source of Peptides That Regulate Autoantibody Production....Pages 371-388
Autoantibodies to Intracellular Antigens in Systemic Lupus Erythematosus Patients That Bind and Penetrate Cells....Pages 389-398
Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice....Pages 399-416
Anti-DNA Antibodies....Pages 417-428
The Anti-DNA Response in Lupus....Pages 429-447
Glomerular Binding Antibodies in Systemic Lupus Erythematosus....Pages 448-470
The Antiphospholipid Syndrome....Pages 471-491
Autoimmune-Associated Congenital Heart Block....Pages 492-513
Role of Calreticulin Autoimmunity in the Pathogenesis of Photosensitive Cutaneous Lupus Erythematosus....Pages 514-528
Complement System and Systemic Lupus Erythematosus....Pages 529-540
Type One Complement Receptor and Human SLE....Pages 541-556
Fcγ Receptor Polymorphisms....Pages 557-573
Immune Complexes and Autoantibodies to C1q....Pages 574-598
Lipids and Lupus....Pages 599-611
Immunosuppressive Agents....Pages 612-641
Treatment of Systemic Lupus Erythematosus by Selective Inhibition of T-Cell Function....Pages 642-655
Targeting Costimulatory and Other Signaling Molecules in Murine Lupus....Pages 656-670
Management of Murine Lupus by Correction of Fas and Fas Ligand-Induced Apoptosis....Pages 671-693
Back Matter....Pages 695-709