Lipoxygenases and their Metabolites: Biological Functions

Front Matter....Pages i-ix
Introductory Remarks....Pages 1-4
Mammalian 15-Lipoxygenases....Pages 5-28
Molecular Cloning of a Second Human 15 S -Lipoxygenase and its Murine Homologue, an 8 S -Lipoxygenase....Pages 29-36
Arachidonate 12-Lipoxygenase Isozymes....Pages 37-44
Expression of Leukocyte-Type 12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits....Pages 45-61
Lipoxygenase Gene Disruption Studies....Pages 63-73
The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain....Pages 75-85
Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions....Pages 87-93
Effect of 15-Hete on the 5-Lipoxygenase Pathway in Neutrophils....Pages 95-105
Adenosine....Pages 107-115
Pharmacological Aspects of 5-Lipoxygenase Inhibition....Pages 117-121
The Hepoxilins....Pages 123-132
Aspirin-Triggered 15-Epi-Lipoxin A 4 and Stable Analogs of Lipoxin A 4 are Potent Inhibitors of Acute Inflammation....Pages 133-149
Modulation of LTB 4 Receptor in T-Lymphocytes by Lipoxin A 4 (LXA 4 ) and Its Role in Delayed-Type Hypersensitivity....Pages 151-163
Receptors for Cysteinyl-Leukotrienes in Human Cells....Pages 165-170
Cysteinyl-Leukotrienes and the Human Lung....Pages 171-179
12( S )-HETE in Cancer Metastasis....Pages 181-191
A 12( s )-Hete Receptor in Lewis Lung Carcinoma Cells....Pages 193-198
Fatty Acids, Eicosanoids, and Hypolipidemic Agents Regulate Gene Expression Through Direct Binding to Peroxisome Proliferator-Activated Receptors....Pages 199-209
Biogenesis and Biological Function of Marine Algal Oxylipins....Pages 211-218
Back Matter....Pages 219-230