Liposome Dermatics: Griesbach Conference

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Percutaneous Absorption and Conventional Penetration Enhancers....Pages 3-10
Lipid Flow Phenomena Between Liposomes, Lipoproteins and Cell Membranes; Applications in Drug Delivery....Pages 11-19
Basic Principles of Liposomes for Drug Use....Pages 20-26
Front Matter....Pages 27-27
Phospholipids as Basic Ingredients....Pages 29-37
Liposome Dermatics: Chemical Aspects of the Skin Lipid Approach....Pages 38-43
Ceramides for Liposomes....Pages 44-56
Liposome Phospholipids: Toxicological and Environmental Advantages....Pages 57-65
Front Matter....Pages 67-67
Liposome Production: Historic Aspects....Pages 69-81
Rationale for the Production and Dermal Application of Lipid Vesicles....Pages 82-90
Liposome Production: The Ethanol Injection Technique and the Development of the First Approved Liposome Dermatic....Pages 91-100
Liposome Production: The Sizing-Up Technology Starting from Mixed Micelles and the Scaling-Up Procedure for the Topical Glucocorticoid Betamethasone Dipropionate and Betamethasone....Pages 101-109
Properties and Characterization of Pre-Liposome Systems....Pages 110-117
Front Matter....Pages 119-119
Changes in the Structure of the Human Stratum Corneum Induced by Liposomes....Pages 121-136
Monitoring in vivo Skin Hydration by Liposomes Using Infrared Spectroscopy in Conjunction with Tape Stripping....Pages 137-149
Liposome Dermatics: Assessment of Long-Term Stability....Pages 150-166
Delivery of Liposome-Encapsulated Agents to Artificial Membranes....Pages 167-171
Topical Delivery of Liposomally Encapsulated Ingredients Evaluated by In Vitro Diffusion Studies....Pages 172-181
Front Matter....Pages 183-183
The Fate of Liposomes in Animal Skin....Pages 185-194
The Fate of Liposomes for Topical Use in Skin Tissue Culture....Pages 195-199
Liposomally Encapsulated Active Ingredients Penetrate Through the Follicle....Pages 200-205
Front Matter....Pages 183-183
Biodisposition of Liposome-Encapsulated Active Ingredients Applied on the Skin....Pages 206-214
Distribution of Liposome-Encapsulated Ingredients in Human Skin Ex Vivo....Pages 215-225
Liposomes as Safe Carriers of Drugs and Vaccines....Pages 226-232
Front Matter....Pages 233-233
Comedolytic Activity of a Liposomal Antiacne Drug in an Experimental Model....Pages 235-241
Topical Delivery of Liposomally Encapsulated Interferon Evaluated by In Vitro Diffusion Studies and in a Cutaneous Herpes Guinea Pig Model....Pages 242-250
Comparative Activity of a Liposomal and a Conventional Econazole Preparation for Topical Use According to a Guinea Pig Tinea Model....Pages 251-257
Liposome-Encapsulated Enzymes for DNA Repair....Pages 258-269
Front Matter....Pages 271-271
General Remarks on Patent Matter....Pages 273-280
Liposome Determatics to Come According to the Patent Literature....Pages 281-287
Clinical Regulatory Aspects of Topical Liposomal Drugs with Special Consideration of Safety Aspects....Pages 288-296
Front Matter....Pages 297-297
Clinical Trial Protocols for Anti-Inflammatory and other Liposome Dermatics....Pages 299-307
Chemical Composition of Liposomes and Its Influence on the Humidity of Normal Skin....Pages 308-314
Influence of Various Topical Liposome Preparations With and Without Active Ingredients on the Cutaneous Blood Flow....Pages 315-319
Increased Activity and Tolerability of a Conventional Glucocorticoid in a Liposomal Form....Pages 320-328
Influence of Liposomal Encapsulation on the Activity of a Herbal Non-steroidal Anti-Inflammatory Drug....Pages 329-337
Front Matter....Pages 339-339
Past, Present and Future of Liposome Cosmetics....Pages 341-345
Liposomes in Drug Delivery: Present and Future....Pages 346-352
Back Matter....Pages 353-360