Lipids, Lipoproteins, and Drugs

Front Matter....Pages i-xii
Opening Remarks....Pages 1-3
Front Matter....Pages 5-5
The Interaction of Apolipoprotein-Alanine (ApoC-III) with Lipids: Study of Structural Features Required for Binding....Pages 7-35
Lipoproteins and Lipid Transport....Pages 37-59
Pathways of Lipoprotein Metabolism: Integration of Structure, Function and Metabolism....Pages 61-76
Steroid Requirements for Suppression of HMG CoA Reductase Activity in Cultured Human Fibroblasts....Pages 77-84
The Immunology of Serum Lipoproteins....Pages 85-102
Front Matter....Pages 103-103
Hormone-Induced Lipolysis and The Metabolic Pathways Providing Energy To The Cell: A Possible Role of Atp As a Rate-Limiting Factor....Pages 105-122
Mechanism of Action of Hypolipidemic Drugs....Pages 123-133
Newer Hypolipidemic Compounds....Pages 135-150
Experimental and Clinical Evaluation of Two “Atromid-S” Analogues in Relation to their Differential Modes of Action....Pages 151-165
Front Matter....Pages 167-167
Pathogenesis of Hyperlipidemias, Clues to Treatment?....Pages 169-183
Serum Lipoprotein Composition in Different Types of Hyperlipoproteinemia....Pages 185-199
Diet in the Management of Hyperlipidemic Patients....Pages 201-219
The Partial Ileal Bypass Operation in Treatment of the Hyperlipidemias....Pages 221-230
Front Matter....Pages 231-231
The Activation and Inhibition of Fibrinolysis....Pages 233-243
The Role of Lipids in the Tissue Factor Pathway of Blood Coagulation....Pages 245-253
Use of Fibrinopeptide a Measurements in the Diagnosis and Management of Thrombosis....Pages 255-264
Modifications of Platelet Functions by Dietary Fats....Pages 265-276
Front Matter....Pages 277-277
Diabetes as a Risk Factor for Arteriosclerotic Vascular Disease....Pages 279-285
Hypertension and other Risk Factors....Pages 287-303
Front Matter....Pages 277-277
The Heritable Hyperlipoproteinemias and Atherosclerosis....Pages 305-316
Smoking and Carbon Monoxide Uptake as a Risk Factor in Atherosclerotic Cardiovascular Disease....Pages 317-321
Risk of Coronary Disease and Coronary Complications by Neural and Psychological Factors....Pages 323-335
Front Matter....Pages 337-337
New Animal Model for Atherosclerosis Research....Pages 339-347
Effects of Various Hypolipidemic Drugs on Fatty Acid Composition of Liver and Serum Lipids....Pages 349-357
Some Aspects of the Chimpanzee as a Model for Experimental Atherosclerosis....Pages 359-369
Studies on Experimental Atherosclerosis by Immunofluorescence....Pages 371-377
The Effects of Tolbutamide on the Development of Atherosclerosis in Rhesus Monkeys Fed an Average American Table-Prepared Diet....Pages 379-380
The Cockerel as an Animal Model for Atherosclerosis Research....Pages 381-391
Influence of Platelets on the Integrity of the Vessel Wall....Pages 393-398
Front Matter....Pages 399-399
Scope and Organization of a Lipid Clinic and Clinical Trials....Pages 401-404
Portacaval Shunt in Two Patients with Homozygous Hypercholesterolemia....Pages 405-416
Planning the Type II Coronary Primary Prevention Trial of the Lipid Research Clinics (U. S. A.)....Pages 417-426
Concluding Remarks....Pages 427-429
Back Matter....Pages 431-515