Lipids and Atherosclerosis (Advances in Translational Medical Science)

List of contributors vii
Foreword xi
Preface xiii
Acknowledgements xiv
1. The assembly of very low density lipoproteins in the liver 1
S-O. Olofsson and L. Asp
2. Cardiovascular implications of partial, tissue-specific silencing of MTP 15
C.C. Shoulders
3. Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targets
for cardiovascular disease 31
J.S. Millar and J.T. Billheimer
4. The biochemical and physiological roles of ACAT1 and ACAT2 in
cholesterol homeostasis and atherosclerosis 41
R.G. Lee and L.L. Rudel
5. Overview of intestinal lipid metabolism 55
T.A. Miettinen and H. Gylling
6. The role of non-cholesterol sterols in the pathogenesis of atherosclerosis
and their modulation by the sitosterolaemia locus 63
E.L. Klett and S.B. Patel
7. FXR: the molecular link between bile acid and lipid metabolism 69
T. Claudel, E. Sturm, B. Staels and F. Kuipers
8. Overview of HDL and reverse cholesterol transport 81
P. Barter
9. LXR as a therapeutic target for atherosclerosis 93
I.G. Schulman and R.A. Heyman
10. Endothelial lipase and the regulation of HDL metabolism 101
K.O. Badellino and W. Jin
11. Cholesteryl ester transfer protein (CETP) inhibition as a therapeutic
strategy for raising HDL-cholesterol levels and reducing atherosclerosis 111
D.J. Rader
Contents
Prelims 14/7/05 4:44 pm Page v
12. Overview of insulin resistance and the metabolic syndrome 119
N. Sattar and B. Mukhopadhyay
13. Peroxisome proliferator activated receptors and energy metabolism 137
P. Gervois, J-C. Fruchart and B. Staels
14. Adipocytes and their secretory products 153
J.B. Prins
15. Regulation of adipocyte triglyceride storage 165
F. Karpe and G.D. Tan
16. Role of innate immunity in atherosclerosis: immune recognition,
immune activation and the atherosclerotic process 175
J-M. Fernández-Real
17. Role of CD44 in atherogenesis and its potential role as a therapeutic target 191
E. Puré
18. Lipoxygenases: potential therapeutic target in atherosclerosis 207
L. Zhao and C.D. Funk
19. Role of secretory phospholipase A2 isozymes (Lp-PLA2) 219
C.H. Macphee
Index