Leukotrienes and Prostacyclin

Front Matter....Pages i-viii
Phospholipases: Link Between Membrane Phospholipids and Arachidonate Metabolites....Pages 1-14
The Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation....Pages 15-41
Biosynthesis and Metabolism of Leukotrienes....Pages 43-53
Analysis of Hydroxy Acids....Pages 55-63
Assay of Leukotrienes....Pages 65-80
Pulmonary and Cardiovascular Pharmacology of Leukotrienes....Pages 81-105
Pharmacology of Leukotriene C 4 in Guinea-Pig....Pages 107-124
Pulmonary Pharmacology of the SRS-A Leukotrienes....Pages 125-134
Effects of Leukotrienes C 4 and D 4 , Cyclic AMP and Methylation Reactions on Arachidonic Acid Metabolism in Rat Peritoneal Macrophages....Pages 135-146
Inhibition of Arachidonic Acid Metabolism....Pages 147-167
Calmodulin Regulates Thromboxane and Prostacyclin Biosynthesis and Metabolism....Pages 169-180
6-Keto-Prostaglandin E 1 : Biosynthesis and Circulatory Effects....Pages 181-193
Metabolism of Prostaglandin D 2 by 11-Ketoreductase in the Rabbit Liver....Pages 195-205
An in Vivo Aggregometer....Pages 207-211
Inhibition of Platelet Aggregation and Cardiovascular Effect of 5E-13,14-Didehydro Carboprostacyclin and 5E-13,14-Didehydro-20-Methyl-Carboprostacyclin....Pages 213-220
Involvement of Prostaglandins in the Fetal and Neonatal Circulation....Pages 221-236
Prostaglandins and Their Synthesis Inhibitors in Cancer....Pages 237-247
Clinical Use of Prostacyclin in Vascular Disease....Pages 249-262
Diagnostic Use of Urinary Thromboxane B 2 ....Pages 263-273
Acute Arachidonate Toxicity....Pages 275-284
Back Matter....Pages 285-298