Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3: Basic Science and Clinical Relevance Part B

Front Matter....Pages i-iv
Front Matter....Pages v-v
Role of Immunity and Inflammation in Corneal and Ocular Surface Disease Associated with Dry Eye....Pages 729-738
Dry eye and Delayed Tear Clearance: “A Call to Arms”....Pages 739-743
Innate Immunity in the Cornea: A Putative Role for Keratocytes in the Chemokine Response to Viral Infection of the Human Corneal Stroma....Pages 745-751
The Role of ICAM-1 as a Signal Protein for Predisposition of Ocular Surface Inflammation....Pages 753-759
Flow Cytometric Analysis of the Inflammatory Marker HLA DR in Dry Eye Syndrome: Results from 12 Months of Randomized Treatment with Topical Cyclosporin A....Pages 761-769
Pathogenesis of Autoimmune Lacrimal Gland Disease in MRL/MPJ Mice....Pages 771-776
ICAM-1: Its Role in the Pathophysiology of Immune Activation in the MRL/LPR Mouse....Pages 777-781
Proinflammatory Cytokine Inhibition of Lacrimal Gland Secretion....Pages 783-787
Effect of Anti-Inflammatory Cytokines on the Activation of Lymphocytes by Lacrimal Gland Acinar Cells in an Autologous Mixed Cell Reaction....Pages 789-794
IL-2 Immunoreactive Proteins in Lacrimal Acinar Cells....Pages 795-799
Immunopathogenesis of Conjunctival Histopathologic Alteration in Non-Sjögren’s Keratoconjunctivitis Sicca....Pages 801-803
Topical Cyclosporine a (2%) Eyedrops in the Therapy of Atopic Keratoconjunctivitis and Keratoconjunctivitis Vernalis....Pages 805-812
Front Matter....Pages 813-813
Apoptosis: The Eyes Have It....Pages 815-820
Apoptosis in the Cornea in Response to Epithelial Injury: Significance to Wound Healing and Dry Eye....Pages 821-826
Mechanisms of Apoptosis in Human Corneal Epithelial Cells....Pages 827-834
A Functional Unit for Ocular Surface Immune Defense Formed by the Lacrimal Gland, Conjunctiva and Lacrimal Drainage System....Pages 835-844
Role of Tear Anti- Acanthamoeba IgA in Acanthamoeba Keratitis....Pages 845-850
Expression of Vascular Endothelial Growth Factor Receptor-3 (Vegfr-3) in the Conjunctiva-A Potential Link Between Lymphangiogenesis and Leukocyte Trafficking on the Ocular Surface....Pages 851-860
Human Lacrimal Drainage-Associated Lymphoid Tissue (LDALT) Belongs to the Common Mucosal Immune System....Pages 861-866
The Crypt System of the Human Conjunctiva....Pages 867-872
Front Matter....Pages 813-813
Organized Mucosa-Associated Lymphoid Tissue in Human Nasolacrimal Ducts....Pages 873-876
Front Matter....Pages 877-877
Contact Lenses and Tear Film Interactions....Pages 879-884
Effects of O 2 Transmissibility on Corneal Epithelium After Daily and Extended Contact Lens Wear in Rabbit and Man....Pages 885-893
Influence of the Tear Film Composition on Tear Film Structure and Symptomatology of Soft Contact Lens Wearers....Pages 895-899
Evaluation of the Pre-Lens Tear Film Forming on Three Disposable Contact Lenses....Pages 901-915
An Evaluation of Mucin Balls Associated with High-Dk Silicone-Hydrogel Contact Lens Wear....Pages 917-923
Cells Collected from the Corneal Surface in Sjögren’s Syndrome, Dry Eye, and Normals....Pages 925-928
The Thickness of the Post-Lens Tear Film Measured by Interferometry....Pages 929-933
Tear Lipid Composition of Hydrogel Contact Lens Wearers....Pages 935-938
Conjunctival Characteristics of Contact Lens Wearers and Nonwearers and Their Association with Symptomatology....Pages 939-943
Dry Eye Symptomatology of Contact Lens Wearers and Nonwearers....Pages 945-949
Contact Lens-Induced Papillary Conjunctivitis Is Associated With Increased Albumin Deposits On Extended Wear Hydrogel Lenses....Pages 951-955
Surface Protein Profile of Extended-Wear Silicon Hydrogel Lenses....Pages 957-960
The Detection of Kinin Activity in Contact Lens Wear....Pages 961-966
Immunoblotting and Tear Sampling Techniques for the Study of Contact Lens-Induced Variations in Tear Protein Profiles....Pages 967-971
Interaction between, the Contact Lens and the Ocular Surface....Pages 973-980
Clinical Benefits and Physical Properties of Addition of Hydroxypropyl Methylcellulose to a Multi-Purpose Contact Lens Care Solution....Pages 981-985
Front Matter....Pages 987-987
Epidemiology of Dry Eye Syndrome....Pages 989-998
Immunogenetics of Autoimmune Exocrinopathy in the Nod Mouse: More Than Meets the Eye....Pages 999-1007
Results of a Dry Eye Questionnaire from Optometric Practices in North America....Pages 1009-1016
Front Matter....Pages 987-987
The Effect of Hormone Replacement Therapy on the Symptoms and Physiologic Parameters of Dry Eye....Pages 1017-1022
Impaired Neurotransmission in Lacrimal and Salivary Glands of a Murine Model of Sjögren’s Syndrome....Pages 1023-1028
Menopause, Hormone Replacement Therapy and Tear Function....Pages 1029-1033
IDD3 and IDD5 Alleles From Nod Mice Mediate Sjögren’s Syndrome-Like Autoimmunity....Pages 1035-1039
Dry Eye Associated with Chronic Graft-Versus-Host Disease....Pages 1041-1045
Contribution of Neurogenic Inflammation to Irritable Eye Syndrome....Pages 1047-1050
Ocular Drying Associated with Oral Antihistamines (Loratadine) in the Normal Population-an Evaluation of Exaggerated Dose Effect....Pages 1051-1055
Evaluation of the Time to “Natural Compensation” in Normal and Dry Eye Subject Populations During Exposure to a Controlled Adverse Environment....Pages 1057-1063
Front Matter....Pages 1065-1065
Diagnosis and Treatment of the Dry Eye: A Clinical Perspective....Pages 1067-1078
Dry Eye Syndromes: Diagnosis, Clinical Trials and Pharmaceutical Treatment-‘Improving Clinical Trials’....Pages 1079-1086
Using Osmolarity to Diagnose Dry Eye: A Compartmental Hypothesis and Review of Our Assumptions....Pages 1087-1095
Reliability of Measurements of Tear Physiology....Pages 1097-1105
Use of Cevimeline, a Muscarinic Ml and M3 Agonist, in the Treatment of Sjögren’s Syndrome....Pages 1107-1116
Drug Development Issues in Pharmacological Treatments for Dry Eye....Pages 1117-1120
Alternative Reference Values for Tear Film Break up Time in Normal and Dry Eye Populations....Pages 1121-1125
Ocular Sensations and Symptoms Associated with Tear Break Up....Pages 1127-1133
Evaluation of the Akorn Dry Eye Test (Dettm) as a Predictor of Contact Lens Comfort....Pages 1135-1140
Predicting Optical Effects of Tear Film Break Up on Retinal Image Quality Using the Shack-Hartmann Aberrometer and Computational Optical Modeling....Pages 1141-1147
Improvement of Tear Stability Following Warm Compression in Patients with Meibomian Gland Dysfunction....Pages 1149-1152
An Evaporative Stress Test for Borderline Dry Eye Detection....Pages 1153-1157
Front Matter....Pages 1065-1065
Tear Production Measurement, Basal or Reflex Assessment?....Pages 1159-1163
Innovative Dry Eye Diagnosis System Using Microbalance Technology....Pages 1165-1169
The Repeatability of Diagnostic Tests and Surveys in Dry Eye....Pages 1171-1175
Association of Clinical Diagnostic Tests and Dry Eye Surveys: The Nei-Vfq-25 and the OSDI....Pages 1177-1181
Economic and Quality Of Life Impact of Dry Eye Symptoms in Women with Sjögren’s Syndrome....Pages 1183-1188
Patient-Reported Versus Doctor-Diagnosed Dry Eye: The Assessment of Symptoms....Pages 1189-1193
Keratoconjunctivitis Sicca Versus Dry Mouth and Autoantibodies in Primary and Secondary Sjögren’s Syndrome....Pages 1195-1199
Tear Spreading Rates: Post-Blink....Pages 1201-1204
Near Vision Accommodation in Horizontality with Vdt: Why Low Blinking and Dry Eye?....Pages 1205-1211
Analysis of Tear Protein Patterns for the Diagnosis of Dry Eye....Pages 1213-1216
The Significance of Salivary Gland Ultrasonography in the Diagnosis of Dry Eye Syndrome....Pages 1217-1220
The Effect of Nasal Mucosal Stimulation on Schirmer Tests in Sjögren’s Syndrome and Dry Eye Patients....Pages 1221-1226
A Simple Method of Detecting the Anti-Inflammatory Action of Topical Dry Eye Treatments....Pages 1227-1232
Efficacy of Sodium Hyaluronate Eye Drops of Different Osmolarities in the Symptomatic Treatment of Dry Eye Patients....Pages 1233-1235
Topical Non-Preserved Diclofenac Therapy for Keratoconjunctivitis Sicca....Pages 1237-1240
The Effect of Botulinum Toxin a Treatment on Tear Function Parameters and on the Ocular Surface....Pages 1241-1246
Efficacy of Autologous Serum Treatment in Patients with Severe Dry Eye....Pages 1247-1250
Ocular Safety of Ins365 Ophthalmic Solution, a P2y 2 Agonist, in Patients with Mild to Moderate Dry Eye Disease....Pages 1251-1257
Ocular Surface Reconstruction with Amniotic Membrane Transplantation in Chemical Burn....Pages 1259-1262
Surgical Reconstruction of the Tear Meniscus at the Lower Lid Margin for Treatment of Conjunctivochalasis....Pages 1263-1268
Front Matter....Pages 1065-1065
The Effect of Punctal Occlusion on Tear Lactoferrin in Aqueous Deficient Dry Eye Patients....Pages 1269-1271
Silicon Punctal Plug Insertion in the Treatment of Severe Dry Eye....Pages 1273-1276
Application of Atelocollagen Solution for Lacrimal Duct Occlusion....Pages 1277-1281
Atelocollagen Punctal Occlusion for the Treatment of the Dry Eye....Pages 1283-1284
Fiberscopic Observation of Canaliculi After Punctal Plug Extrusion....Pages 1285-1288
Front Matter....Pages 1289-1289
Neural Stem Cells for Cns Repair: State of the Art and Future Directions....Pages 1291-1296
Particle-Mediated Gene Transfer to Ocular Surface Epithelium....Pages 1297-1308
In Vivo Gene Transfer Into Corneal Epithelial Progenitor Cells By Viral Vectors....Pages 1309-1314
Gene Therapy for the Prevention of Corneal Haze after Photorefractive/Phototherapeutic Keratectomy Excimer Laser Surgery....Pages 1315-1321
Ex Vivo Preservation and Expansion of Human Limbal Epithelial Stem Cells on Amniotic Membrane for Treating Corneal Diseases with Total Limbal Stem Cell Deficiency....Pages 1323-1334
Corneal Blindness from End-Stage Sjögren’s Syndrome and Graft-Versus-Host Disease....Pages 1335-1338
Front Matter....Pages 1339-1339
Closing Address: The Academic Perspective....Pages 1341-1342
Industry Perspective....Pages 1343-1344
Addendum....Pages 1345-1348
Back Matter....Pages 1349-1385