Kidney Transplantation

Contents
Preface
Chapter 1
Calcium – Phosphorus Metabolism and Mineral – Bone Disease after Kidney Transplantation
	Abstract
	1. Introduction
	2. Role of the Kidney in Calcium-Phosphorus Metabolism: Healthy Subjects
	3. Calcium-Phosphorus Metabolism in Chronic Kidney Disease (CKD). CKD-Related  Mineral Bone Disease (MBD)
		3.1. Pathophysiology
		3.2. CKD-MBD: Biochemical Abnormalities
		3.3. CKD-MBD: Bone Disease
		3.5. CKD-MBD: Vascular Involvement
			3.5.1. CKD-MBD
			3.5.2. Atherosclerosis
	4. Post-Transplant Calcium-Phosphorus Metabolism and MBD
		4.1. Post-Transplant Calcium – Phosphorus Metabolism: Pathophysiology and Biochemical Abnormalities
			4.1.1. Vitamin D
			4.1.2. Calcium, Phosphate, PTH
			4.1.3. Monitoring and Treatment of CaP Abnormalities
		4.2. Post-Transplant Calcium – Phosphorus Metabolism:  Bone Disease
			4.2.1. Diagnosis and Fracture Risk Evaluation
				4.2.1.1. Bone Mineral Density (BMD)
				4.2.1.2. FRAX Score
				4.2.1.3. Bone Biopsy
				4.2.1.4. Bone Turnover Markers (BTMs)
				4.2.1.5. Other Tools
			4.2.2. Treatment of Post-Transplant Bone Disease
				4.2.2.1. Calcium, Phosphate, Vitamin D Supplementation/Calcitriol/Vitamin D Analogues
				4.2.2.2. Calcimimetics
				4.2.2.3. Antiresorptive Therapy: Bisphosphonates
				4.2.2.4. Antiresorptive Therapy: Denosumab
				4.2.2.5. PTH Analogues
				4.2.2.6. Parathyroidectomy
				4.2.2.7. Other Therapeutic Options
		4.3. Post-Transplant Calcium – Phosphorus Metabolism: Vascular Calcification
			4.3.1. Diagnosis and Clinical Importance of Post-Transplant VC
			4.3.2. Treatment of Post-Transplant VC
				4.3.2.1. Immunosuppression
				4.3.2.2. Vitamin D Supplementation
				4.3.2.3. Other Therapeutic Options
	Conclusion
	References
Chapter 2
Psychosocial Assessment of the Live Kidney Donor and Recipient
	Abstract
	1. Introduction
		1.1. Psychosocial Evaluation of the Recipient  in the Pre-Transplant Period
			1.1.1. Assessments
			1.1.2. Approach to Psychological Conditions and Psychopathologies
			1.1.3. Cognitive Assessment
			1.1.4. Social Support Assessment
			1.1.5. Assessment Tools
			1.1.6. Psychosocial Requirements for Renal Transplantation
		1.2. Psychosocial Evaluation of the Live Donor
		1.3. Post-Transplant Follow-Up
	Conclusion
	References
Chapter 3
Donor Nephrectomy Techniques
	Abstract
	Introduction
	Surgery Techniques
		Open Donor Nephrectomy
		Minimal Invasive Open Donor Nephrectomy
		Laparoscopic Transperitoneal Donor Nephrectomy
		Retroperitoneoscopic Donor Nephrectomy
		Hand-Assisted Laparoscopic/Retroperitoneoscopic  Donor Nephrectomy
		Robot-Assisted Donor Nephrectomy
	Operational Variables
		Donor Nephrectomy Side
		Multiple Renal Arteries and Veins
		Warm Ischemia Time and Duration of Surgery
		Elderly Donors
		Obese Donors
	Post-Operative Variables
		Complications
		Long-Term Follow-Up
		Recipient Kidney Function
		Cost
	Conclusion
	References
Chapter 4
Nephrectomy Timing for Polycystic Kidneys in Autosomal Dominant Polycystic Kidney Disease Patients Listed for Transplantation
	Abstract
	Autosomal Dominant Polycystic Kidney Disease
	Pre-Transplant Evaluation
		Native Nephrectomy of Renal Transplant Recipients
		with Autosomal-Dominant Polycystic Kidney Disease
		Indications for Native Nephrectomy
	Nephrectomy Procedures
	Multiorgan Transplantation
	Use of ADPBH Kidneys As Donor Kidney
	References
Index
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