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از ساعت 7 صبح تا 10 شب
ویرایش: [3 ed.]
نویسندگان: Alexander P. Demchenko
سری:
ISBN (شابک) : 3031190882, 9783031190889
ناشر: Springer
سال نشر: 2023
تعداد صفحات: 771
[772]
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 27 Mb
در صورت تبدیل فایل کتاب Introduction to Fluorescence Sensing: Volume 2: Target Recognition and Imaging به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب مقدمه ای بر حسگر فلورسانس: جلد 2: تشخیص و تصویربرداری هدف نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
Preface Contents 1 Principles Governing Molecular Recognition 1.1 Multivalency: The Principle of Molecular Recognition 1.1.1 Multivalent Pattern of Molecular Interactions 1.1.2 Energetics and Kinetics in Molecular Recognition 1.1.3 Reversibility in Molecular Interactions and Mass Action Law 1.2 Lock-And-Key, Induced Fit, Conformation Selection and Induced-Assisted Folding Models 1.3 Realization of Principles of Molecular Recognition in Fluorescence Sensing 1.3.1 The Output Parameters Used in Fluorescence Sensors 1.3.2 Different Strategies in Fluorescence Sensing 1.4 Molecular Recognition of Different Strength and Specificity 1.4.1 Sensors Providing Strong Highly Specific Binding 1.4.2 Sensors Based on Competitive Target Binding 1.4.3 Sensors Based on Reversible Specific Binding and Operating in a Large Volume 1.5 Direct Reagent-Independent Sensing 1.6 Simultaneous Analysis of Multiple Analytes 1.6.1 Systems for Detection of Multiple Analytes 1.6.2 Specific Target Recognition Versus Pattern Recognition Sensor Arrays 1.7 Sensing and Thinking. Current Trends that Should Be Highlighted References 2 Basic Theoretical Description of Sensor-Target Binding 2.1 Parameters that Need to Be Optimized in Every Sensor 2.1.1 The Limit of Detection and Sensitivity 2.1.2 Dynamic Range of Detectable Target Concentrations 2.1.3 The Sensor Selectivity 2.1.4 Multivalent Binding and Cooperativity 2.2 Determination of Binding Constants 2.2.1 Dynamic Association-Dissociation Equilibrium 2.2.2 Determination of Kb by Titration 2.2.3 Determination of Kb by Serial Dilutions 2.3 Modeling the Analyte Binding Isotherms 2.3.1 Receptors Free in Solution or Immobilized to a Surface 2.3.2 Bivalent and Polyvalent Reversible Target Binding 2.3.3 Reversible Binding of Analyte and Competitor 2.3.4 Reversible Interactions in a Small Volume 2.4 Kinetics of Target Binding 2.5 Formats for Fluorescence Detection 2.5.1 Linear Response Format 2.5.2 Intensity-Weighted Format 2.6 Sensing and Thinking. How to Provide the Optimal Quantitative Measure of Target Binding? References 3 Recognition Units Built of Small Macrocyclic Molecules 3.1 Crown Ethers and Cryptands: Macrocyclic Hosts for Ions 3.2 Cavity-Forming Compounds. Structures and Properties 3.2.1 Cyclodextrins 3.2.2 Calix[n]arenes 3.2.3 Cucurbit[n]urils 3.2.4 Pillar[n]arenes 3.2.5 Comparison of Properties and Prospects of Supramolecular Macrocycles 3.3 Porphyrins and Porphyrinoids. Unique Coupling of Recognition and Reporting 3.4 Sensing and Thinking. The Recognition Properties of Parent Binders and of Their Derivatives References 4 Sensors Based on Peptides and Proteins as Recognition Units 4.1 Designed and Randomly Synthesized Peptides 4.1.1 The Development of Peptide Sensors 4.1.2 Randomly Synthesized Peptides, Why They Do Not Fold? 4.1.3 Template-Based Approach 4.1.4 The Exploration of ‘Mini-Protein’ Concept 4.1.5 Molecular Display Including Phage Display 4.1.6 Peptide Binders for Protein Targets and the Prospects of Peptide Sensor Arrays 4.1.7 Antimicrobial Peptides and Their Analogs 4.1.8 Advantages of Peptide Technologies and Prospects for Their Development 4.2 Sensors Based on Protein-Based Display Scaffolds 4.2.1 Engineering the Binding Sites by Mutations 4.2.2 Scaffolds Employing Proteins of Lipocalin Family 4.2.3 Other Protein Scaffolds 4.3 Natural Ligand-Binding Proteins and Their Modifications 4.3.1 Bacterial Periplasmic Binding Protein (PBP) Scaffolds 4.3.2 Engineering PBPs Binding Sites and Response of Environment-Sensitive Dyes 4.3.3 Serum Albumins 4.4 Antibodies and Their Recombinant Fragments 4.4.1 Assay Formats Used for Immunosensing 4.4.2 The Types of Antibodies and Their Fragments Used in Sensing 4.4.3 Prospects for Antibody Technologies 4.5 Sensing and Thinking. The Application Range and Benefit from Peptide and Protein Sensors References 5 Nucleic Acids as Scaffolds and Recognition Units 5.1 DNA and RNA Fragments in Hybridization-Based Sensing 5.1.1 The Types of Nucleic Acid Recognition Units 5.1.2 Fluorescence Reporting in Hybridization Assays 5.2 Nucleic Acid Aptamers 5.2.1 Selection and Production of Aptamers 5.2.2 Integration with Fluorescence-Responding Units 5.2.3 Aptamer Applications and Comparison with Other Binders 5.3 G-quadruplex-Based Analytical Sensing Platforms 5.3.1 Production and Properties of G-quadruplexes 5.3.2 Fluorescence Reporters for G-quadruplex Structures 5.3.3 Applications of G-quadruplex Sensing Technology 5.4 The DNA i-motif in Sensing 5.5 Sensing and Thinking: The Versatile Recognizing Power of Nucleic Acids References 6 Self-assembled, Porous and Molecularly Imprinted Supramolecular Structures in Sensing 6.1 Molecular Recognition on Supramolecular Scale 6.1.1 Assembly of Organic and Inorganic Functionalities 6.1.2 The Major Building Blocks 6.1.3 Realization of Multiple Recognition Sites in Self-assembled Structures 6.2 Formation and Operation of Supramolecular Fluorescent Sensors 6.3 Fluorescence Sensing with Nanoporous and Mesoporous Materials 6.3.1 Sensing Designed on the Basis of Mesoporous Silica 6.3.2 The Hydrogel Layers in Sensor Technologies 6.3.3 Porous Structures Formed of Organic Polymers 6.3.4 Metal–Organic Frameworks 6.4 Molecularly Imprinting in the Polymer Volume 6.4.1 The Principle of Formation of Imprinted Polymers 6.4.2 The Coupling of Molecular Recognition with Reporting Functionality 6.4.3 Imprinted Polymers in the Form of Nanoparticles and Microspheres 6.4.4 Exploration of Collective Properties of Fluorescent Dye Aggregates and Conjugated Polymers 6.4.5 Nanomaterials with Molecularly Imprinted Sensing 6.4.6 Formation of Nanocomposites with Molecular Imprinting Functionalities 6.5 Sensing and Thinking: Extending the Fluorescence Sensing Possibilities with Designed and Spontaneously Formed Nano-ensembles References 7 Fluorescence Sensing Operating at Interfaces 7.1 The Structural and Dynamic Properties of Surfaces and Interfaces 7.1.1 Gas–Liquid Interfaces 7.1.2 Liquid–Liquid Interfaces 7.1.3 Solid–Liquid Interfaces 7.1.4 Solid–Solid Interfaces 7.2 The Self-assembled Functional Surfaces 7.2.1 Formation of Functional Surfaces 7.2.2 The Active Surfaces in Active Use 7.2.3 Organic Dyes Forming Active Surfaces 7.2.4 Supported Layers of Conjugated Polymers 7.3 Preferential Location of Solutes in the Systems of Structural Heterogeneity and on Active Surfaces 7.4 Binding Affinity at Interfaces 7.5 Surface-Imprinted Sensors and Biosensors 7.5.1 Surface Imprinting on Support 7.5.2 Nanoparticle-Based Surface Imprinting 7.6 Sensing and Thinking. The Strong Contribution of Surfaces and Interfaces to Sensor Technologies References 8 Fluorescence Sensing of Physical Parameters and Chemical Composition in Gases and Condensed Media 8.1 Sensing the Physical Parameters of Environment: Temperature and Pressure 8.1.1 Molecular Thermometry 8.1.2 Luminescence for Pressure Measurement 8.2 Fluorescence Studies in a Gas Phase 8.2.1 Optimal Receptors for the Gas State Molecules 8.2.2 Determining the Natural Gas Phase Composition 8.2.3 Detection of Hydrocarbon Gasses 8.2.4 Dangerous Compounds and Explosives 8.3 Characterization of Solvents and Their Intermolecular Interactions 8.3.1 Solvent Polarity Scaling 8.3.2 Physical Modeling of Solvent Polarity Effects 8.3.3 Wavelength-Ratiometric Response to Solvent Polarity 8.3.4 Solvent Polarity and Hydrogen Bonding 8.3.5 Preferential Solvation in Mixed Solvents 8.4 Fluorescence Probing of Molecular Dynamics in Liquid State 8.4.1 Rotating Sphere Approach 8.4.2 Segmental Probe Rotations and Their Application 8.4.3 Molecular Rotors Relaxing to TICT State 8.4.4 Dyes Exhibiting the Excited-State Planarization 8.5 Dynamics of Solvent Relaxations 8.5.1 Solvation Dynamics Studied by Time-Resolved Spectroscopy 8.5.2 Site-Selective Dynamics in Molecular Ensembles 8.6 Detection of Traces of Water in Low-Polar Liquids 8.7 Condensed-Phase Media of Special Interest: Supercritical Liquids, Ionic Liquids and Liquid Crystals 8.7.1 Molecular Structure and Dynamics in Supercritical Fluids 8.7.2 The Properties of Ionic Liquids 8.7.3 Liquid Crystals 8.8 The Structure and Dynamics in Polymers 8.8.1 Monitoring the Polymerization Process 8.8.2 Structures and Structural Transitions in Polymers 8.9 Sensing and Thinking. The Value of Information on Correlation of Macroscopic and Microscopic Variables References 9 Quantitative Fluorescent Detection of Ions 9.1 Fluorophore-Based Determination of pH 9.2 Determination of Concentration of Cations 9.2.1 Fluorescent Sensors for Alkali and Alkaline Earth Metal Cations 9.2.2 Sensing the Transition Metal Ions 9.2.3 Detection of Heavy Metal Ions 9.2.4 Potential for λ-Ratiometric Sensing Based on Excited-State Intramolecular Proton Transfer 9.3 Sensing the Anions 9.4 Sensing and Thinking. Selecting the Ways to Apply the Principle of Wavelength-Ratiometry to Sensing Ions References 10 Detection and Imaging of Small Molecules of Biological Significance 10.1 Gaseous Molecules of Physiological Signaling—Gasotransmitters 10.1.1 Carbon Monoxide 10.1.2 Nitric Oxide 10.1.3 Hydrogen Sulfide 10.2 Oxygen and Reactive Oxygen Species 10.2.1 Determination of Oxygen Concentration 10.2.2 Hydrogen Peroxide 10.2.3 Hypochlorous Acid/Hypochlorite 10.3 Detection of Biothiols (Cysteine, Homocysteine and Glutathione) 10.4 Biologically Relevant Phosphate Anions 10.5 Adenosine and Guanosine Triphosphates 10.6 Redox Cofactors NADH/NAD+ and NAD(P)H/ NAD(P)+ 10.7 Sensing and Thinking. The Problem of Simultaneous Sensing and Imaging of Many Analytes References 11 Detection, Structure and Polymorphism of Nucleic Acids 11.1 DNA Detection and Analysis of Its Conformation 11.1.1 Double-Stranded DNA Structures 11.1.2 Analysis of Single-Stranded DNA 11.1.3 Identification of Non-canonical DNA Forms 11.2 Recognition of Specific DNA Sequences by Hybridization 11.2.1 The Microarray ‘DNA Chip’ Hybridization Techniques 11.2.2 Sandwich Assays in DNA Hybridization 11.2.3 Molecular Beacon Technique 11.2.4 Specific DNA Sensing with the Aid of Conjugated Polymer 11.2.5 DNA Structure Recognition with Peptide Nucleic Acids 11.2.6 The Use of Nanomaterials in DNA Hybridization 11.3 Probing on the Level of Single Nucleic Acid Bases 11.3.1 Design of Local Site Responsive Sensors 11.3.2 Operation with Parameters of Fluorescence Emission 11.3.3 Probing the Single-Nucleotide Polymorphism 11.4 RNA Detection, Analysis and Imaging 11.4.1 RNA Detection in Cells 11.4.2 RNA G-quadruplexes 11.5 Sensing and Thinking. Increase of Sensitivity: Amplify the Target or the Detection System? References 12 Fluorescence Detection of Peptides, Proteins, Glycans 12.1 Targeting Peptides 12.2 Detection of Protein Targets 12.2.1 Determination of Total Protein Content 12.2.2 Labeling the Surface of Native Proteins 12.2.3 The Recognition of Protein Surface by Small Molecules 12.2.4 Protein Sensing with Peptide, Protein and Nucleic Acid Receptors 12.2.5 Molecularly Imprinted Polymers in Protein Sensing 12.2.6 Sensor Arrays and Machine Learning Algorithms 12.3 Analysing Pathological β-Aggregated Forms of Proteins 12.3.1 Organic Dyes as the Sensors for β-Sheets 12.3.2 Following the Kinetics of Amyloid Formation 12.4 Polysaccharides and Glycoproteins 12.5 Sensing and Thinking. Precise Affinity Sensors or Chemical Noses? References 13 Detection of Harmful Microbes 13.1 Detection and Identification of Vegetative Bacteria 13.1.1 The Whole-Cell Detection 13.1.2 Detection by Characteristic Features of Cell Surface 13.1.3 Detection Based on Bacterial Genome Analysis 13.2 Discovery and Recognition of Bacterial Spores 13.3 Identification and Analysis of Biofilms 13.4 Detection of Toxins 13.5 Sensors for Viruses 13.5.1 Nucleic Acid Based Detection 13.5.2 Recognition of Viruses by Antibodies and Aptamers 13.6 Sensing and Thinking. Future Trends in Pathogen Detection: Single-Particle Sensitivity Versus Signal Amplification References 14 Clinical Diagnostics Ex-Vivo Based on Fluorescence 14.1 Biological Fluids Available for Sensing 14.2 Detection of Disease Biomarkers 14.2.1 Diagnostics of Cancer 14.2.2 Diagnostics with Cardiac Biomarkers 14.2.3 The Markers of Autoimmune Disorders 14.2.4 Kidney-Related Diseases 14.2.5 Neurodegenerative Diseases 14.3 Glucose Sensing in Diagnosis and Treatment of Diabetes 14.4 Uric Acid 14.5 Cholesterol 14.6 Sensing and Thinking. The Era of Digital Health is Approaching? References 15 Imaging and Sensing Inside the Living Cells. From Seeing to Believing 15.1 Modern Fluorescence Microscopy 15.1.1 Epi-Fluorescence Microscopy 15.1.2 Total Internal Reflection Fluorescence Microscopy (TIRF) 15.1.3 Confocal Fluorescence Microscopy 15.1.4 Programmable Array Microscope 15.1.5 Two-Photon and Three-Photon Microscopy 15.1.6 Time-Resolved and Time-Gated Imaging 15.1.7 Wavelength-Ratiometric Imaging 15.1.8 Traditional Far-Field Fluorescence Microscopy: Advances and Limitations 15.2 Far-Field Super-Resolution Microscopy 15.2.1 Breaking the Diffraction Limit 15.2.2 Stimulated Emission Depletion (STED) Microscopy 15.2.3 Single Molecule Localization Microcopy 15.2.4 Structured Illumination Microscopy (SIM) 15.2.5 Correlative Light and Electron Microscopy 15.3 Sensing and Imaging on a Single Molecule Level 15.3.1 The Reason to Study Single Molecules 15.3.2 Single-Molecular Studies in Solutions 15.3.3 The Studies of Molecular Motions and Interactions 15.3.4 Single Molecules Inside the Living Cells 15.4 Site-Specific Intracellular Labeling and Genetic Encoding 15.4.1 Attachment of Fluorescent Reporter to Any Cellular Protein 15.4.2 Genetically Engineered Protein Labels 15.4.3 Co-synthetic Incorporation of Fluorescence Dyes 15.5 Advanced Nanosensors Inside the Cells 15.5.1 Fluorescent Dye-Doped Nanoparticles 15.5.2 The Quantum Dots Applications in Imaging 15.5.3 Carbon Nanoparticles in Cell Research 15.6 The Studies of Intracellular Motions 15.6.1 Single-Particle Tracking 15.6.2 Viscosimetry Inside the Living Cell 15.7 Sensing Within the Cell Membrane 15.7.1 Membrane Structure and Dynamics 15.7.2 Lipid Asymmetry and Apoptosis 15.7.3 Sensing the Membrane Potential 15.7.4 Visualizing Membrane Receptors 15.8 Sensing and Thinking. Intellectual and Technical Means to Go Deeper into Cellular Functions References 16 Fluorescent Imaging In Vivo 16.1 Optical Properties of Biological Tissues 16.1.1 Light Propagation Through Tissues 16.1.2 Optical Windows in Near-Infrared 16.2 Fluorescence Contrast Agents and Reporters 16.2.1 Organic Dyes and Their Nanocomposites 16.2.2 Nanomaterials 16.3 Optimal Imaging Techniques 16.3.1 Imaging and Microscopy in NIR-I Window 16.3.2 Instrumentation for NIR-II Range 16.4 The Studies on the Level of Tissue Imaging 16.4.1 Contrasting the Blood Vessels and Lymph Nodes 16.4.2 Monitoring Inflammatory Diseases and Response to Therapy 16.4.3 Imaging Cancer Tissues 16.5 Fluorescence Image-Guided Surgery 16.6 Cell Tracking Inside the Living Body 16.6.1 The Procedures for Cell Labeling 16.6.2 Tracking Hematopoietic and Cancer Cells 16.6.3 Tracing the Stem Cells 16.7 Combination of Fluorescence with Photoacoustic Tomography 16.8 Sensing and Thinking. Towards the Progress in Functional Bioimaging References 17 Phototheranostics: Combining Targeting, Imaging, Therapy 17.1 Light in Theranostics Technologies 17.2 Photothermal Therapy 17.2.1 The Choice of Wavelengths 17.2.2 The Choice of Materials 17.3 Photodynamic Therapy 17.3.1 The Factors Needed for Realizing Photodynamic Therapy 17.3.2 The Mechanisms of Tumor Destruction 17.4 Combining All Power of Phototheranostics 17.4.1 Photoactivation of Prodrugs and Controlling the Drug Release 17.4.2 Photoimmunotherapy with Near-Infrared Light 17.4.3 Non-oncological Clinical Applications 17.4.4 Photothermal and Photodynamic Inactivation of Harmful Microbes 17.5 Sensing and Thinking. The Strategy of Controlling the Diagnostics and Treatment by Light References 18 Fluorescent Light Opening New Horizons 18.1 Genomics, Proteomics and Other ‘Omics’ 18.1.1 Genomic and Gene Expression Analysis 18.1.2 The Analysis of Proteome 18.1.3 Addressing Interactome 18.1.4 Outlook. Analysis on a Single-Cellular Level 18.2 Unprecedented Scale of Complexity, How to Deal With It? 18.2.1 Combinatorial Synthetic Approach on a New Level 18.2.2 Advanced Sensors in Discovery of New Products 18.2.3 Electronic (Photonic) Noses and Tongues 18.2.4 Realizing the Pattern Recognition Principle 18.2.5 Navigating Massive Datasets: Transforming Information into Knowledge 18.3 New Level of Clinical Diagnostics 18.3.1 The Progressing Sensor Developments 18.3.2 The Sensing in Whole Blood 18.3.3 Gene-Based Diagnostics 18.3.4 Confronting the Global Virus Pandemic 18.4 Sensors Promising to Change the Society 18.4.1 Industrial Challenges and Safe Workplaces 18.4.2 Biosensor-Based Lifestyle Management 18.4.3 Wearable, Implantable and Digestible Miniature Sensors Are a Reality 18.4.4 Living in a Safe Environment and Eating Safe Products 18.5 Sensing and Thinking. Where Do We Stand and Where Should We Go? References Epilogue Index