Inhibitors of the Ras Superfamily G-proteins, Part A

Content: 
Copyright
Page iv

Preface
Page ix
Fuyuhiko Tamanoi

Chapter One - The Ras Superfamily G-Proteins
Pages 1-14
Ashley L. Tetlow, Fuyuhiko Tamanoi

Chapter Two - NMR Study to Identify a Ligand-Binding Pocket in Ras
Pages 15-39
Till Maurer, Weiru Wang

Chapter Three - The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
Pages 41-67
Christian W. Johnson, Carla Mattos

Chapter Four - State 1(T) Inhibitors of Activated Ras
Pages 69-94
Hans Robert Kalbitzer, Michael Spoerner

Chapter Five - Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras–Inhibitor Binding Interface
Pages 95-116
Alessandro Di Domizio, Francesco Peri

Chapter Six - Development of EHop-016: A Small Molecule Inhibitor of Rac
Pages 117-146
Suranganie Dharmawardhane, Eliud Hernandez, Cornelis Vlaar

Chapter Seven - Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
Pages 147-168
Susanne Schmidt, Anne Debant

Chapter Eight - Targeting the Dbl and Dock-Family RhoGEFs: A Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
Pages 169-191
Anne Blangy, Philippe Fort

Chapter Nine - Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
Pages 193-212
Dominico Vigil, Channing J. Der

Chapter Ten - A Two-Hybrid Approach to Identify Inhibitors of the RAS–RAF Interaction
Pages 213-248
Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi, Erica A. Golemis

Chapter Eleven - Inhibitors of K-Ras Plasma Membrane Localization
Pages 249-265
Kwang-jin Cho, Dharini van der Hoeven, John F. Hancock

Chapter Twelve - Ras Chaperones: New Targets for Cancer and Immunotherapy
Pages 267-289
Yoel Kloog, Galit Elad-Sfadia, Roni Haklai, Adam Mor

Author Index
Pages 291-322

Subject Index
Pages 323-330