Inflammatory Diseases and Copper: The Metabolic and Therapeutic Roles of Copper and Other Essential Metalloelements in Humans

Front Matter....Pages i-xxi
Introduction to the Session on Physiological Aspects of Copper Metabolism....Pages 1-1
Copper Homeostasis....Pages 3-15
Estrogen Modulation of Blood Copper and Other Essential Metal Concentrations....Pages 17-30
The Role of Leukocyte Endogenous Mediator (Endogenous Pyrogen) in Inflammation....Pages 31-43
Computer Analysis of Low Molecular Weight Copper Complexes in Biofluids....Pages 45-59
Ceruloplasmin: Experimental Anti-Inflammatory Activity and Physicochemical Properties....Pages 61-72
Introduction to the Afternoon Session on Physiological Aspectes of Copper Metabolism....Pages 73-74
Wilson’s Disease....Pages 75-84
Copper Metabolism in Menkes’ Syndrome and Mottled Mouse Mutants....Pages 85-96
Intestinal Content of the Copper-Binding Protein in Brindled, Blotchy and Crinkled Mice and Cellular Copper Transport....Pages 97-107
Teratogenic Effects of Copper Deficiency and Excess....Pages 109-121
An Appraisal of Current Human Copper Nutriture....Pages 123-136
Environmental Metal Ion Perturbations, Especially as They Affect Copper Status, are a Factor in the Etiology of Arthritic Conditions: An Hypothesis....Pages 137-143
Introduction to the Session on Biochemical Aspects of Copper Metabolism....Pages 145-145
Hormonal Regulation of Copper and Zinc Metabolism in Isolated Rat Liver Parenchymal Cells....Pages 147-157
Ceruloplasmin: A Multi-Functional Cupro-Protein of Vertebrate Plasma....Pages 159-169
Comparison of the Catalytic Activities of Mammalian Ceruloplasmins....Pages 171-181
Lysyl Oxidase, a Molecular Target of Copper....Pages 183-198
Cu-Zn Superoxide Dismutase....Pages 199-207
The Carboxylation of Preprothrombin....Pages 209-220
Introduction to Session on the Biological Aspects of Copper Metabolism....Pages 221-222
The Effect of Ceruloplasmin and Iron on the L-Ascorbic Acid Induced Depolymerization of Hyaluronic Acid....Pages 223-229
Copper, Free Radicals and Rheumatoid Arthritis....Pages 231-242
Hepatic Adaptation Process during Inflammatory Conditions: Role of Trace Elements, Lipid Peroxidation and Ceruloplasmin....Pages 243-253
Roles of Superoxide in Inflammation and Ischemic Shock....Pages 255-266
The Metabolism of Gold: Possible Mechanisms for Perturbations of Copper and Zinc Homeostasis....Pages 267-286
Introduction to the Session on Antiinflammatory Activities of Copper Complexes....Pages 287-287
Copper Complexes as the Active Metabolites of Antiinflammatory Agents....Pages 289-301
Comparison of the Antiinflammatory Activities of Copper Complexes in Different Models of Inflammation....Pages 303-318
The Copper Problem and Amino Acids....Pages 319-327
Copper and Inflammation....Pages 329-345
Antiinflammatory Activity of Implanted Copper....Pages 347-359
Antiulcer, Antimicrobial and Anticancer Activities of Copper Introductory Remarks....Pages 361-362
The Antiulcer Activities of Copper Complexes....Pages 363-373
Development and Therapeutic Actions of Oral Copper Complexes of Anti-Inflammatory Drugs....Pages 375-390
Antimycoplasma Approach to the Mechanism and the Control of Rheumatoid Disease....Pages 391-407
The Antimycoplasmal Activity of Copper Bipyridyl Complexes....Pages 409-422
Antitumor SOD Compounds....Pages 423-433
Therapy of Rheumatic Diseases....Pages 435-437
Copper-Salicylate in Rheumatoid Arthritis and Similar Degenerative Diseases....Pages 439-452
Therapy of Inflammatory Diseases with Superoxide Dismutase....Pages 453-467
The Results of a Copper Bracelet Clinical Trial and Subsequent Studies....Pages 469-482
Treatment of Rheumatoid Arthritis With Zinc Sulfate....Pages 483-493
Immunomodulation Imposed by Chronic Treatment with D-Penicillamine and Zinc in the Mouse....Pages 495-510
Introduction to Session: Possible Mechanisms of Action of the Essential Metals....Pages 511-512
Reactivity of Chelated Copper with Superoxide....Pages 513-527
Molecular Mechanism of Zinc Action, and a Note on the Treatment of SLE in the Mouse with Zinc....Pages 529-542
Stabilization of Gamma Globulin with Copper Complexes: Possible Relevance to the Etiology of Rheumatoid Arthritis....Pages 543-552
In Vitro Studies of Anti-Inflammatory Copper Complexes: Some Difficulties in their Chemical Interpretation....Pages 553-564
Mechanisms of Action of Metal Ions on Hepatocytes....Pages 565-580
Modulation of Lymphocyte Function by Copper and Thiols....Pages 581-598
Immunological Consequences of Copper Deficiency in Mice....Pages 599-599
Selenium in Rheumatoid Arthritis and in Liver Cirrhosis....Pages 600-600
Influence of Oral Zinc Intake on Whole Blood and Plasma Levels of Copper....Pages 601-601
Pancreas and Copper Metabolism The Influence of Pancreatic Secretions on Cu Metabolism....Pages 602-602
Effect of Dietary Copper on Adjuvant Arthritis in the Rat....Pages 603-603
The Influence of Thiols on Superoxide Dismutase Activity in Erythrocytes....Pages 604-604
Leucocyte Superoxide Dismutase in Rheumatoid Arthritis....Pages 605-605
Back Matter....Pages 607-622