Inflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future Trends in Inflammation Organized by the European Biological Research Association and held in London, 18th–22nd February 1980

Front Matter....Pages i-xxxiii
Front Matter....Pages 1-1
The participation of mononucleur phagocytes in immune based inflammatory processes with special reference to their secretory responses....Pages 3-10
Future trends in mechanisms of cartilage destruction (Abstract)....Pages 11-13
New developments in leukocyte Chemotaxis research: a survey....Pages 15-26
Future trends in free radical studies....Pages 27-42
Future trends in the immunopathology of rheumatoid arthritis....Pages 43-53
Future trends in anti-rheumatic drugs....Pages 55-59
Front Matter....Pages 61-61
A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs....Pages 63-78
Review of immunotherapy in rheumatoid arthritis....Pages 79-97
Crystal deposition disease....Pages 99-106
T-cell dependent inflammatory responses....Pages 107-113
Arachidonic acid peroxidation in inflammation and its inhibition as a mechanism for anti-inflammatory activity....Pages 115-127
General Discussion....Pages 129-130
Front Matter....Pages 131-131
Review of pathogenesis of adjuvant arthritis and its relation to rheumatoid arthritis (Abstract)....Pages 133-133
The anti-inflammatory activity of aspirin: the active metabolite....Pages 135-140
Indomethacin-sodium salicylate combination/RGH-6705 as a new possibility in the treatment of inflammation (Abstract)....Pages 141-141
Tropesin: a new potential anti-rheumatic ester of indometacin....Pages 143-147
Development of an Arthus-like model of induced inflammation and its use in the anti-inflammatory characterization of orgotein (bovine Cu-Zn superoxide dismutase)....Pages 149-156
The inhibition of macrophage accumulation in rats following injection of complete Freund’s adjuvant (Abstract)....Pages 157-157
Possible synergism between ovariectomy and oestradiol in preventing Freund’s adjuvant arthritis in the rat....Pages 159-168
Anti-inflammatory actions of an immunomodulator: therafectin 1,2- O -isopropylidene-3- O -3′-( N’, N’ -dimethylamino n-propyl)-D-gluco-furanose, HCl....Pages 169-180
Front Matter....Pages 131-131
Effects of benoxaprofen on macrophage function (Abstract)....Pages 181-181
Some ‘anti-arthritic’ properties of an oversulphated glycosaminoglycan in degenerative joint disease....Pages 183-191
Anti-arthritic properties of ICI 55897 (Clozic) (Abstract)....Pages 193-193
Effect of ICI 55897 (Clozic), indomethacin and dexamethasone on collagenase and prostaglandin production by cultured rheumatoid synovial tissue (Abstract)....Pages 195-196
The use of thymopoietin as an anti-inflammatory agent (Abstract)....Pages 197-197
Production of hydrogen peroxide from neutrophils of rats (Abstract)....Pages 199-199
Effects of D-penicillamine on granulation tissue and connective tissue of skin, aorta and bone in rats (Abstract)....Pages 201-201
D-penicillamine in rheumatoid arthritis: fixed versus variable regimes....Pages 203-207
Effects of anti-inflammatory drugs on polymorphonuclear leukocyte aggregation (Abstract)....Pages 209-209
Aggregation of rat polymorphonuclear leukocytes in vitro by chemotactic factors (Abstract)....Pages 211-212
Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis....Pages 213-225
Front Matter....Pages 233-233
Changes in the inflammatory mediator content in the colonic mucosae of immune colitides in guinea pigs (Abstract)....Pages 235-236
Simultaneous continuous monitoring of blood volume and permeability in rabbit synovium: action of histamine....Pages 237-240
Leukotriene B: a biologically active release product of polymorphonuclear leukocytes....Pages 241-248
Arachidonic acid metabolism by lipoxygenase in leukocytes of different species and the chemokinetic activity of some products (Abstract)....Pages 249-250
Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates (Abstract)....Pages 251-251
The possible role of divalent cations, microtubules and cyclic nucleotides in lymphokine induced macrophage aggregation....Pages 253-257
Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract)....Pages 259-260
Mechanism of inhibition of prostaglandin biosynthesis by anti-inflammatory steroids....Pages 261-265
Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity....Pages 267-283
Front Matter....Pages 233-233
Human haptoglobin: an endogenous inhibitor of prostaglandin synthase....Pages 285-300
Release of thromboxane B 2 and PGE 2 by rabbit polymorphonuclear leukoctyes (Abstract)....Pages 301-302
Prostaglandin and thromboxane production by rat macrophages (Abstract)....Pages 303-304
Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis....Pages 305-311
Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis....Pages 313-320
Observations on the influence of anti-oxidant compounds on prostaglandin biosynthesis (Abstract)....Pages 321-322
Preliminary data on the influence of thyroid function on prostaglandin biosynthesis (Abstract)....Pages 323-323
Front Matter....Pages 333-333
Effect of pharmacological agents on macrophage accumulation....Pages 335-341
The histology of cotton pellet and polyvinyl sponge induced granulomas in rats (Abstract)....Pages 343-343
A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacin (Abstract)....Pages 345-346
Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides....Pages 347-353
An in vitro mouse macrophage model for use in assessing the effects of anti-inflammatory drugs....Pages 355-364
Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages....Pages 365-372
Comparison between calcium pyrophosphate and monosodic urate induced inflammations of the palatal connective tissue....Pages 373-385
Intracellular killing of micro-organisms by phagocytic cells: the effect of extracellular stimuli (Abstract)....Pages 387-388
 In vivo studies on the influence of antigen induced joint inflammation on patellar hyaline articular cartilage....Pages 389-394
A stereological analysis of collagen phagocytosis in a model of chronic inflammation in rats (Abstract)....Pages 395-395
Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes....Pages 397-403
Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract)....Pages 405-405
Correlation between aggregative and Chemotaxis inducing activities of five chemotactic peptides (Abstract)....Pages 407-408
Front Matter....Pages 333-333
On the mechanism of human polymorphonuclear leukocyte deactivation of chemotaxis by the synthetic peptide formyl-methiony-leucyl-phenylalanine....Pages 409-416
Dynamics of membranes in viable leukocytes associated with cellular recognition and biological memory in chemotaxis and promotion of locomotion in chemokinesis(Abstract)....Pages 417-418
Front Matter....Pages 427-427
Quantitative assessment of experimentally induced arthritis in guinea pigs using microfocal radiography....Pages 429-438
Glutathione in erythrocytes: a parameter of change in disease activity and response to drugs in rheumatoid arthritis....Pages 439-449
Effect of drugs on serum copper and its correlation with other humoral factors in rheumatoid arthritis....Pages 451-456
The effect of therapeutic agents on serum copper levels and serum oxidase activities in the rat adjuvant model compared to analogous results from studies of rheumatoid arthritis in humans....Pages 457-463
Serum and synovial fluid ferritin in rheumatoid arthritis....Pages 465-469
Circulating and intra-articular immune complexes in rheumatoid arthritis: their relationship with disease activity....Pages 471-476
β 2 -Microglobulin, anti-β 2 -microglobulin activity and circulating immune complexes in rheumatoid arthritis: seric and synovial studies....Pages 477-487
Technetium-99m labelled leukocytes: preparation, animal studies and potential application....Pages 489-495
Knee rheumatoid synovitis (KRS) successfully treated with intra-articular rifamycin SV (Abstract)....Pages 497-497
HLADR typing and rheumatoid arthritis (RA) (Abstract)....Pages 499-499
Preliminary studies comparing 67 Ga uptake with 99m Tc uptake and clinical score in rheumatoid arthritis (Abstract)....Pages 501-502
Front Matter....Pages 507-507
Macrophage activation by Listeria -specific T cell sub-populations (Abstract)....Pages 509-509
Activation of mouse peritoneal macrophages and of the alternative pathway of the complement system by cartilage specific collagen type II....Pages 511-522
Interaction of macrophages and synthetic polyanions in the inflammatory response....Pages 523-534
Activation of complement by metal compounds that induce chronic granulomatous inflammation....Pages 535-542
Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells....Pages 543-546
RES impairment in NZB/W mice....Pages 547-554
Rheumatoid immunoblasts and the effect of gold and cytotoxic drugs....Pages 555-560
Front Matter....Pages 507-507
Immunological and clinical effects of human placenta-eluted gammaglobulins (PEGG) in rheumatoid arthritis....Pages 561-572
Modification of antibody responses during non-specific acute inflammation (Abstract)....Pages 573-573
Levamisole and thymopoietin pentapeptide (TP5) correction of E-rosette depression in man: in vitro and in vivo studies....Pages 575-580
Comparison between a curative and a preventive effect of an immunological therapy on an experimental gingivitis....Pages 581-587
A prospective study of 17 autoantibodies (AA) in 176 cases of rheumatoid arthritis (RA) treated with D-penicillamine (DP) (Abstract)....Pages 589-589
Lymphokines, monokines, leukokines: large scale production, isolation and properties of leukocyte-derived cytotaxins, cytokinesins, cytotoxins and mitogens (Abstract)....Pages 591-592
Front Matter....Pages 601-601
Experimental protoporphyria in hairless mice: Photodermatitis....Pages 603-615
Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis....Pages 617-628
Morphological studies of inflammatory reactions: the relationships between the delayed-type hypersensitivity reaction and the Arthus reaction induced in the rat with ovalbumin....Pages 629-637
Regulatory mediators in Arthus reactions: demonstration of chemotactic factor inactivator and cell directed inhibitor activity....Pages 639-645
Regulatory mediators in Arthus reactions: lysosomal enzymes in biopsy and serum....Pages 647-653
Effect of flurbiprofen on prostaglandin synthesis (Abstract)....Pages 655-655
Intrapleural injection of asbestos induces early sister chromatid exchanges increase in bone marrow cells (Abstract)....Pages 657-657
The effect of an acute inflammatory process on the resistance to infections in mice....Pages 659-664
Interaction of inflammatory stimuli: diminished inflammatory response induced by cell accumulation at a distant site (Abstract)....Pages 665-666
Anti-inflammation in spontaneously arising animal cancers....Pages 667-674
Effect of tumour growth on inflammatory macrophages....Pages 675-682
Effect of an acute inflammatory process on tumour development....Pages 683-690
Role of endogenous pyrogen in the rabbit febrile responses to muramyl dipeptide (Abstract)....Pages 691-691
Front Matter....Pages 701-701
Comparative migration of guinea pig T and B lymphocytes from capillary tubes (Abstract)....Pages 703-703
Front Matter....Pages 701-701
T lymphocyte sub-populations in rheumatoid arthritis....Pages 705-708
Enkephalins and the immune system (Abstract)....Pages 709-709
Experimental Inhibition of E-rosette forming cells by in vitro incubation with adenosine, theophylline and verapamil....Pages 711-716
Lymphocytes bearing Fcγ receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and ‘high avidity’ EA rosettes....Pages 717-724
‘L’ lymphocytes, immune complexes and the amplification of human T lymphocyte proliferation....Pages 725-734
Influence of anti-inflammatory drugs on PHA-stimulated lymphocyte proliferation with variable numbers of macrophages....Pages 735-745
Influence of regional blood flow and inflammation on the localization of lymphoblasts in the small intestine of the mouse....Pages 747-756
Early lymphocyte activation and proliferative response induced by lectins: individual variations in man....Pages 757-763
Lymphocyte responsiveness in acute and convalescent infectious mononucleosis (Abstract)....Pages 765-765
Quantitative measurement of human leukocyte aggregation as a possible correlation with cell mediated immunity....Pages 767-771
Front Matter....Pages 781-781
Macrophages as origin of factor increasing monocytopoiesis (FIM) (Abstract)....Pages 783-784
Phagocytosis and enzymatic activity of PGE 1 treated rat peritoneal macrophages (Abstract)....Pages 785-785
Alterations in bone marrow leukocyte ultrastructure and alkaline phosphatase activity accompanying a peripheral inflammatory response in the rat (Abstract)....Pages 787-788
 In vivo inhibition of pmn migration by antimacrophage serum....Pages 789-793
Macrophage involvement in chemotactic response....Pages 795-801
Determination of free lipid A and endotoxin (Abstract)....Pages 803-803
Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic....Pages 805-813
Influence of colchicine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monosodium urate crystals....Pages 815-821
Biological and biochemical activities of in vitro differentiating murine bone marrow macrophages (Abstract)....Pages 823-824
Effect of synovial tissue on the matrix of articular cartilage in organ culture (Abstract)....Pages 825-825
Front Matter....Pages 781-781
Effect of irradiation and cell reconstitution on the macrophage mitogenic activity of exudate and inflammatory serum....Pages 827-835
Effect of chronic inflammatory exudate on cell morphology and cell functions (Abstract)....Pages 837-837
Macrophages are activated by endocytosis of α 2 -macroglobulin-protease complexes to produce neutral proteases....Pages 839-843
A mitogenic factor for macrophages present in rat serum (Abstract)....Pages 845-845
Secretion of plasminogen activator by mouse peritoneal macrophages elicited by injection of a suspension of killed streptococci....Pages 847-849
Back Matter....Pages 859-873