In Vivo Immunology: Histophysiology of the Lymphoid System

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Bone Marrow and B Cell Differentiation....Pages 3-10
Migration of Erythropoietic and Prebursal Stem Cells from the Early Chicken Embryo to the Yolk Sac....Pages 11-17
Antigens Associated with Bursal and Thymic Reticular Epithelial Cells....Pages 19-23
The Development of B Lymphocytes and Their Reactivity in Pig Fetuses....Pages 25-30
Regulation of B Cell Development in Mouse Bone Marrow....Pages 31-38
Distribution and Functional Properties of PNA + and PNA - Cells in Central and Peripheral Lymphoid Organs of the Chicken....Pages 39-45
Peanut Agglutinin (PNA) Binding as a Marker for Immature Human B Lymphocytes. Is Bone Marrow not the Complete Bursa-Equivalent?....Pages 47-52
Functional Studies on Subpopulations of B-Lymphocytes and Bone Marrow Cells....Pages 53-59
Human Sessile B Lymphocyte Marker Defined by a Monoclonal Antibody....Pages 61-65
Marginal Zones: The Largest B Cell Compartment of the Rat Spleen....Pages 67-73
The Proliferative Activity of Antibody Forming Cells in the Mouse Bone Marrow....Pages 75-81
The Origin of Marginal-Zone Cells....Pages 83-90
Functional Antigen Binding by the Defective B Cells of CBA/N Mice....Pages 91-96
The Role of Bursal Microenvironment in the Maturation of B Cells....Pages 97-102
Fluorescence Activated Cell Sorter Analysis of Murine B Cell Development....Pages 103-109
Pre B Cell Leukaemia in the Rat....Pages 111-118
Differences in In Vivo Functional Capacities of Avian Precursor B and T Cells Following In Vitro Incubation....Pages 119-126
Lymphoid Antigens on Non-Lymphoid Factor-Dependent Haemopoietic Cell Lines....Pages 127-135
Front Matter....Pages 137-137
Experimental Approaches to Lymphocyte Traffic: Pitfalls of the Tracer Sample Method....Pages 139-145
Two Populations of Murine LPS-Responsive B Lymphocytes Differing in Recirculatory Capacity....Pages 147-152
Front Matter....Pages 137-137
A Method for Studying the Dynamics of the Primary Migration of Human Lymphocytes Using Indium-III Oxine Cell Labelling....Pages 153-160
LYT Phenotype and Lectin Binding Properties of Mouse Lymphocytes which Enter Lymph Nodes....Pages 161-165
Unilateral Localization of Hapten-Specific B Memory Cells in Lymph Node Draining a Footpad Injection of Antigen....Pages 167-178
Organ-Specific Homing of B-Cell Hybridomas....Pages 179-185
Isolation of Factors Causing Enhanced Lymphocyte Adherence to High Endothelial Venules in Vitro....Pages 187-192
Lymphocyte-Endothelial Interactions and Histocompatibility Restriction....Pages 193-198
Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition....Pages 199-206
The Effect of Stimulated Macrophages on High Endothelial Venules and Germinal Centres in Lymph Nodes of Rat....Pages 207-212
Homing Pattern of Newly Formed Splenic Lymphocytes....Pages 213-218
The Efficiency of Entry of Lymphoid Cells into Lymphoid and Non-Lymphoid Tissues....Pages 219-224
Morphological Aspects of the Local Immune Response to Influenza in Rats....Pages 225-233
Front Matter....Pages 235-235
Thymus, T-Cell Differentiation and the T-Cell System....Pages 237-240
Detection of MHC, Thy-1, Lyt-1 And Lyt-2 Antigens in the Developing Mouse Thymus....Pages 241-248
Role of Thymic Medullary Lymphocytes in the Intra-Thymic Maturation Process....Pages 249-254
Sequential Development of Thy-1 + Subpopulations in Regenerating Thymus after Bone Marrow Transplantation....Pages 255-261
“Thymic Nurse Cells” Contain the First Virus Producing Cells after Inoculation of the Radiation Leukemia Virus in C57BL/Ka Mice....Pages 263-267
Studies on the Maturity of Cells Migrating from the Thymus to the Periphery in Mice....Pages 269-274
Lymphocytes in Mice with Membrane Antigens Common to Human Thymocytes....Pages 275-280
Cloned T Cell Progenitors from Mouse Bone Marrow Give Rise to Lymphocytes with Multiple Anti-H-2 Reactivities....Pages 281-287
Frequency and Restriction of Cytotoxic T Lymphocyte Precursors in Neonatally Thymectomized Mice....Pages 289-295
Front Matter....Pages 235-235
Accumulation of Mature T and B Cells and Abnormalities of Lymphocyte Traffic in the Thymus of Aged NZB × SJL F 1 Female Mice....Pages 297-302
Structural and Functional Alterations of the Aging Human Thymus....Pages 303-312
Study of Beta Adrenoceptors on Subpopulations of Thymocytes Separated on Ficoll-Hypaque Density Gradients....Pages 313-318
Lymphocyte Differentiation in the Rabbit Thymus....Pages 319-325
Monoclonal Antibodies Against Rat T Cells....Pages 327-333
Ontogeny of the Immune System in Fish — Role of the Thymus....Pages 335-341
The Thymus-Hypophysis Interaction in the Developing Chick Embryo: Thymic Epithelial Cells in Hypophysectomized Embryos....Pages 343-348
Monoclonal Antibodies to Cell Surface Antigens on Lymphoid and Non-Lymphoid Cells of the Mouse....Pages 349-356
Cultured Thymic Epithelium. Its Morphological Characterization and Biological Effect in Vivo in Athymic Nude Rats....Pages 357-364
Ontogeny of LYT 1 and LYT 123 Lymphocytes in the Mouse Thymus....Pages 365-370
Front Matter....Pages 371-371
Introduction: Non-Lymphoid Cells and Factors in Immune Reactions....Pages 373-374
Evidence for Extrinsic Origin of Ia Positive Cells in Embryonic Murine Thymus....Pages 375-380
Ia Positive Cells in the Medulla of Rat Thymus are Bone Marrow Derived....Pages 381-387
Morphological Assessment of Immunologically Relevant Cells in the Thymus....Pages 389-399
The Principal Cells in the Thymus Expressing MHC Antigens are Epithelial....Pages 401-405
Interdigitating cells. A Guiding Cell Line in T-Cell Reactivity....Pages 407-414
The Immunological Significance of Birbeck Granule Containing Cells....Pages 415-420
A Comparative Study of Accessory Cells Derived from the Peritoneum and from Solid Tissues....Pages 421-428
Characterization of Bone Marrow Derived Macrophage as Ia-Bearing Accessory Cells....Pages 429-433
The Frequency and Surface Markers of Antigen-Laden Cells in Thoracic Duct Lymph....Pages 435-440
Front Matter....Pages 371-371
Rat Thymus Micro-Environment: An Ultrastructural and Functional Characterization....Pages 441-446
The Effect of Veiled Cells on Lymphocyte Function....Pages 447-454
Effect of an Acute Viral Infection by a Silent Virus on the Humoral Immune Responses....Pages 455-460
Modulatory Effects of Splenic Accessory Cells on in Vivo Antibody Response....Pages 461-462
Macrophages, Langerhans Cells, Interdigitating and Dendritic Accessory Cells: A Summary....Pages 463-468
Front Matter....Pages 469-469
Gut and Bronchus Associated Lymphoid Tissue: An Overview....Pages 471-477
Intestinal Mast Cells and Their Relation to Mesenteric Lymph Nodes....Pages 479-483
Ultrastructural Analysis of Lymphoid Subpopulations and Their Relation to Stationary Cells in the Epithelial Crypts and the Follicles during Early Ontogeny of the Human Tonsilla Palatina....Pages 485-490
Histology and Immunohistochemistry of Bronchus Associated Lymphoid Tissue (BALT) in The Rat....Pages 491-497
Preferential Uptake of Soluble Antigen by Respiratory Tract Epithelium Overlying Bronchus-Associated Lymphoid Tissue in the Rat....Pages 499-505
Macrophage Function in Peyer’s Patch Epithelium....Pages 507-513
Development of Immune Potential and Migration Pattern of Cells from Germfree (GF) and Conventionally (CONV) Reared Rats....Pages 515-520
Unique Functional Characteristics of Mucosal Mast Cells....Pages 521-527
Front Matter....Pages 529-529
H-2-Restriction of T Cells Mediating Lethal Graft-Versus-Host-Disease to Minor Histocompatibility Determinants....Pages 531-536
Induction of Either Acute or Chronic Graft-Versus-Host Disease Due to Genetic Differences Among Donor T Cells....Pages 537-544
Subpopulations of T Cells in the Rat that Mediate Graft-Versus-Host Reactions and Lethal Graft-Versus-Host Disease....Pages 545-551
Alterated Immunological Reactivity in Rats Sustaining a Graft-Versus-Host-Reaction (GvHR)....Pages 553-561
Specific Systemic Graft-Versus-Host Resistance: Failure to Induce in Adult F 1 Rats Tolerized at Birth to Anti-MHC Receptors on Parental T Cells....Pages 563-567
The Rowett Nude (rnu) Rat as a Host in the Popliteal Lymph Node GVH Reaction....Pages 569-576
Specific Suppression of Anti-Host Immune Reactivity in Graft-Versus-Host Reaction....Pages 577-583
Front Matter....Pages 529-529
Systemic Immunomodulation Induced by a “Loco-Regional” GVHR in the Rat....Pages 585-590
Lymphoid Tissue Transplantation in Rats Leads to a GVHR, Inducing a Specific T-Cell Mediated Autoreactivity Against MHC-Antigens....Pages 591-597
Front Matter....Pages 599-599
Immunoregulatory Factors Produced by Activated Lymph Nodes In Vivo ....Pages 601-607
Impairment of Antigen-Specific T Cell Proliferative Response in B Cell Suppressed Mice....Pages 609-615
T Cell-Dependent B Cell Lymphoproliferation and Activation Induced by the Drug Diphenylhydantoin....Pages 617-622
Negative Selection of Discrete Subgroups of T Helper Cells Restricted by Determinants Present on I-A and I-A/E Molecules....Pages 623-627
Induction and Suppression of Delayed-Type Hypersensitivity to Sheep Red Blood Cells by Anti-Idiotypic Antiserum....Pages 629-633
Genes of the Major Histocompatibility Complex Control Transmission of Information Between Initiator and Recruited T Lymphocyte....Pages 635-641
The Role of I-J Subregion Gene Products in the Inhibition of Delayed-Type Hypersensitivity to Major Histocompatibility Antigens by Specific Suppressor T Cells....Pages 643-650
Nonspecific Suppression of Anti-Graft Immunity by Antigen-Specific T Suppressor Cells....Pages 651-658
Cell-Interactions in the Splenic Suppression Caused by Antigen-Feeding....Pages 659-668
Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F 1 Mice Undergoing Graft-Versus-Host Reaction (GVHR)....Pages 669-677
Impaired Host Resistance Against Local JMV Marek’s Disease Tumors after Thymectomy and After Bursectomy....Pages 679-685
Lack of Suppressor T Cells in Renal Transplant Recipients and Activation by Aminophylline....Pages 687-691
Secondary in Vivo Cytotoxic T Cell Responses to Minor Histocompatibility Antigens....Pages 693-698
Cellular and Genetic Basis of the Relative Resistance to the Induction of Experimental Allergic Encephalomyelitis (EAE) in Albino Oxford (AO) Rats....Pages 699-702
Quantitative Aspects of the Nonspecific Humoral Immune Response to Sheep Erythrocytes....Pages 703-710
The Effect of Cyclosporin a on Spontaneous Autoimmune Thyroiditis in Obese Strain (OS) Chickens....Pages 711-717
Characteristics of IL-3 Derived and IL-3 Dependent Lymphocyte Cell Lines....Pages 719-724
Developmental Aspects of T-Suppressor Cells Induced by Hapten-Carrier Conjugates....Pages 725-731
Front Matter....Pages 599-599
Immune Response Regulation....Pages 733-736
Front Matter....Pages 737-737
Introduction....Pages 739-742
The Role of T Cells in B Cell Priming and Germinal Centre Development....Pages 743-749
Expression of T Cell Antigens by Cells in Mouse and Human Primary and Secondary Follicles....Pages 751-756
Localization Patterns of Germinal Center Cell Subsets Differing in Density and in Sedimentation Velocity....Pages 757-763
Surface Phenotype and Migratory Capability of Peyer’s Patch Germinal Center Cells....Pages 765-772
Separation and Characterization of Tonsillar Germinal Centre Lymphocytes Using Peanut Lectin....Pages 773-780
Non-Lymphoid Cells from Rat Intestinal Lymph....Pages 781-789
Effect of Immunological Adjuvants on the Appearance of Monocyte and Dendritic Cell Precursors in Rat Thoracic Duct Lymph....Pages 791-799
Dendritic Reticulum Cell Sarcoma: A Rare Tumor of the Follicular Compartment....Pages 801-808
Immunoperoxidase Analysis of B and T Cell Populations in Human Lymphoid Follicles....Pages 809-816
Disparity between Humoral Antibody Formation and Proliferative Reactions in Lymph Nodes: C57L/J vs. Haired and Hairless HRS/J MICE....Pages 817-822
Isolation and Properties of Spleen Follicular Dendritic Cells....Pages 823-827
Immunocytological Characterization of the Constituent Cells of the Secondary Nodules in Human Tonsils — II....Pages 829-835
Lymph Macrophages Enter the Germinal Center of Regional Lymph Nodes....Pages 837-841
Formation of Germinal Centers in the Rat Thymus....Pages 843-844
Maturity of Precursor Cells for Germinal Centers....Pages 845-847
Back Matter....Pages 849-852