In Vitro Effects of Mineral Dusts: Third International Workshop

Front Matter....Pages I-XIII
Toxicity Testing of Mineral Dusts. Past. Present. Future....Pages 1-6
Front Matter....Pages 7-7
Physicochemical Properties of Minerals Relevant to Biological Activities: State of the Art....Pages 9-24
Surface Active Sites and Catalytic Properties of Asbestos Mineral. Possible Consequence for their Activity in Biological Medium....Pages 25-30
Investigations into the Mechanisms of Asbestos Toxicity....Pages 31-38
Particle Size and Chemically-Induced Variability in the Membrolytic Activity of Quartz: Preliminary Observations....Pages 39-50
The Target Cells for Inhaled Mineral Dusts....Pages 53-58
A Potential Role for Oxygen Radicals in Mineral Dust-Induced Lung Injury: Lessons from Lung Injury from Hyperoxia....Pages 59-65
Mechanisms of Toxic Injury by Asbestos Fibers: Role of Oxygen-Free Radicals....Pages 66-74
Release of Superoxide Anion and Hydrogen Peroxide by Macrophages in Response to Asbestos....Pages 75-81
Stimulation of Neutrophil Chemiluminescence by Alveolar Macrophages from Patients Exposed to Asbestos....Pages 83-91
Broncho Alveolar Lavage in Coal Worker’s Pneumoconiosis: Oxidant and Antioxidant Activities of Alveolar Macrophages....Pages 93-100
Summary and Synthesis of Part I. Role of Physico-Chemical Properties of Minerals (A)....Pages 101-102
Summary and Synthesis of Part I. Cellular Effects of Mineral Dusts (B)....Pages 103-105
Front Matter....Pages 107-107
Immune Responses Induced by Mineral Dusts....Pages 109-119
Effect of Asbestos Preparations on the Random Migration Pattern of Rabbit Alveolar Macrophages....Pages 121-127
Inhaled Asbestos Fibers Produce Complement-Derived Chemotactic Factor(s) on Alveolar Surfaces....Pages 129-138
Immunoregulation During Experimental Asbestosis....Pages 139-147
Enhanced Interleukin Production and Alveolar Macrophage Ia Expression After Asbestos Inhalation....Pages 149-157
Cytotoxicity of Native-and Surface-Modified Asbestos....Pages 159-165
Summary and Synthesis of Part II. Immune Responses and Immunotoxicity....Pages 167-168
Front Matter....Pages 169-169
Cell Transformation: State of the Art....Pages 171-176
Toxicity of Asbestos and Glass Fibers for Rat Tracheal Epithelial Cells in Culture....Pages 177-184
Transformation of Mammalian Cells in Culture by Asbestos and Other Mineral Dusts: A Mechanism Involving Chromosomal Mutation....Pages 185-196
Asbestos-Associated Chromosomal Changes in Human Mesothelial Cells....Pages 197-202
Induction of Transformation in Cultured Rat Pleural Mesothelial Cells by Chrysotile Fibres....Pages 203-207
Preliminary Results on Oncogenes in Rat Pleural Mesothelial Cells Transformed in Vitro by Benzo(a)pyrene and/or chrysotile....Pages 209-214
Comparative Responses of Cultured Cells to Asbestos Fibres in Relation to Carcinogenicity....Pages 215-220
Effect of Asbestos on the Microsomal Metabolism and Bioactivation of Polynuclear Aromatic Hydrocarbons....Pages 221-228
Effect of Fibrous Mineral Dusts on the Aryl Hydrocarbon Hydroxylase Activity of Rat Alveolar Macrophages in Vitro....Pages 229-235
Cytokinetic Effect and Cytotoxic Action of Chromium Compound on Human Fibroblast in Culture....Pages 237-245
Mutagenic Activity of Benzo(a)pyrene-coated Particles....Pages 247-252
In Vitro Simulation of Concurrent Exposures to Asbestos Fibers and Nitrosamines....Pages 253-259
Genotoxic Effects of Natural and Man-made Mineral Fibers....Pages 261-265
Lipid Peroxidation and the Generation of Malondialdehyde in Crocidolite-treated Cell Cultures....Pages 267-273
Summary and Synthesis of Part III. Carcinogenicity and Related Genotoxic Events....Pages 275-279
Front Matter....Pages 281-281
Cell-derived Mediators in Relation to Asbestos-Related Tissue Injury and Fibrogenesis....Pages 283-290
Production of Arachidonic Acid Metabolites by Alveolar Macrophages Treated with Asbestos....Pages 291-295
Exposure of Small Airways to Cristobalite In Vitro....Pages 297-303
Asbestos and Fibrous Glass Induce Biosynthesis of Polyamines in Tracheobronchial Epithelial Cells In Vitro....Pages 305-311
The Release of Inflammatory Mediators from Cells Treated with Leached Asbestos....Pages 313-319
Front Matter....Pages 281-281
Bioassays for Mineral Dusts and Other Particulates....Pages 323-335
Autacoids and Peptides in Normal and Asbestos-exposed Rat Lungs: Tissue and Isolated Cell Contents....Pages 337-343
Early Cellular Changes in Crocidolite-Induced Pulmonary Fibrosis....Pages 345-352
Secretion of Fibronectin by Dust-induced Alveolar Macrophages....Pages 353-358
Bronchoalveolar and Lung Tissue Analyses in Asbestos-exposed Humans and Sheep....Pages 359-367
Progress in Studies on Experimental Silicosis and in the Characterization of the Fibrogenic Factor....Pages 369-376
Asbestos Fibers Enhance the Production of a Mesothelial Cell-derived Soluble Factor which Stimulates Fibroblast DNA Synthesis....Pages 377-382
Summary and Synthesis of Part IV. Synthesis and Release of Mediators (A)....Pages 383-383
Summary and Synthesis of Part IV. Effects of Mineral Dusts on Cell Metabolism in Relation to Inflammation and Fibrogenesis (B)....Pages 385-386
Front Matter....Pages 387-387
In Vitro Cytotoxicity Systems for Mineral Dusts. State of the Art....Pages 389-396
The Effects of Fiber Length on the In Vitro Cytotoxicity of Asbestos Samples in Three Different Assay Systems....Pages 397-404
Comparisons of the Biological Effects of Mineral Fibre Samples Using in Vitro and in Vivo Assay Systems....Pages 405-411
Effects of Amosite Fibers of Different Sizes on Lavagable Cells and Epithelial Permeability of the Lung....Pages 413-420
Relationships between in Vitro Toxicity, Tissue Effects and Mineralogical Composition of Coal Mine Dusts....Pages 421-431
Properties of Mixed Mine Dusts and Their Relationship to Pneumoconiosis....Pages 433-440
In Vitro Cytotoxicity of Fibrous and Non-Fibrous Lead Chromate Particles in Human Bronchial Epithelial Cells and Rat Alveolar Macrophages....Pages 441-448
Front Matter....Pages 451-451
Evaluation of Dust Toxicity by Short-Term Methods....Pages 453-458
Alveolar Macrophage-derived Growth Factor for Fibroblasts: A Potential Mediator of Asbestos-induced Fibrosis....Pages 459-465
Adsorption of 3-Methylcholanthrene onto Chrysotile Fibres Enhances Aryl Hydrocarbon Hydroxylase Inducement in Mice....Pages 467-474
In Vitro Cytotoxicity Testing of Fly Ash Samples with Bovine Lung Macrophages....Pages 475-475
Front Matter....Pages 451-451
Adsorption Properties for PAH of Asbestos and Iron Oxides, in Relation with Their Activity in Biological Medium....Pages 477-482
Involvement of Superoxide Radical in the Toxicity of Mineral Fibers....Pages 483-488
Biological Effects of Fume Silica (Amorphous Type)....Pages 489-496
Importance of Grain Size and Mineral Content of Coal Mine Dusts for Cytotoxicity on Macrophages in Vitro....Pages 497-504
Attapulgite: Preparation Of a Large Quantity Of Inhalable Dust Needed For The Realization Of In Vivo and In Vitro Biological Studies....Pages 505-509
Chromosomal Changes in Cultured Rat Mesothelial Cells Treated with Benzo-3-4- Pyrene and/or Chrysotile Asbestos....Pages 511-514
Erionite-Related Diseases in Turkey....Pages 515-519
A Comparison of in Vitro and in Vivo Toxicity of Mineral Dusts....Pages 521-527
Determination of the Phagocytic Capacity of Rat Alveolar Macrophages Following Exposure to Inhalable Fibrous and Non-Fibrous Dust Fractions....Pages 529-532
Increased Cellular Density in the Presence of Asbestos Fibers....Pages 533-538
Failure of Attapulgite to Produce Tumors: Prediction of this Result by in Vitro Cytotoxicity test....Pages 539-542
Interaction of DNA with Silicic Acid....Pages 543-548