Immune Reactivity of Lymphocytes: Development, Expression, and Control

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Differentiation and Ontogeny of Lymphoid Cells....Pages 3-11
The Ontogeny of Bursa- and Thymus-Specific Cell Surface Antigens in the Chicken....Pages 13-18
IgA Surface Determinants on Cells from the Chicken Embryo....Pages 19-23
Contribution of the Bursa of Fabricius to the Maturation of the B Cell System in Chickens....Pages 25-31
Bursa of Fabricius: Uptake of Radioactive Particles and Radiotoxic “Sealing” of Bursal Follicles....Pages 33-39
The Need for Transcription and Translation for Differentiation of Bone Marrow Cells by Thymic Factors in Man....Pages 41-50
Immunological Potential of Yolk Sac Cells....Pages 51-57
Ontogeny of T Lymphocytes Studied in Athymic and Foetal Mice....Pages 59-62
Ontogeny of T Cell Function in the Fetal Lamb....Pages 63-68
Involvement of Cells With ‘B’ Properties in Development of T Helpers....Pages 69-75
Studies on the Development of Immunity: General Considerations....Pages 77-80
Front Matter....Pages 81-81
Surface Properties of Lymphoid Cells — Introduction....Pages 83-85
Is a Specialized Stimulator Cell Required for the Induction of Allograft Immunity?....Pages 87-93
Cell Selection in the Thymus of Mice Treated with Escherichia Coli Lipopolysaccharide (LPS)....Pages 95-99
Clonal Expansion and Thymus Dependence. Microculture Experiments with TNP-Lipopolysaccharide....Pages 101-106
Cellular Events Involved in the True Primary Immune Response of Splenocytes in Vitro....Pages 107-115
Nonspecific Esterase Activity in T Cells....Pages 117-122
Thymocyte Subpopulations as Stimulators in the Mixed Lymphocyte Reaction....Pages 123-127
Clonal Proliferation of Human Stimulated Lymphocytes on Agar Culture....Pages 129-134
Spontaneous and Induced Changes in Thymus Pattern....Pages 135-140
Front Matter....Pages 81-81
Thymocyte Maturation in AKR Leukemia....Pages 141-146
Lymphocytes and Hemopoietic Bone Marrow Cells — Antigenic Relationships between these Cells and Lymphatic Tissue Repopulation from Stem Cells....Pages 147-152
Demonstration of Two Distinct Macrophage Specific Antigenic Determinants in Rats....Pages 153-158
Surface Properties of Lymphoid Cells — Summing Up....Pages 159-162
Front Matter....Pages 163-163
Microenvironment to a Lymphoid Cell is nothing more than Interaction with its Neighbours....Pages 165-169
Scanning Electron Microscopy of B- and T-Cells in Peripheral Lymphoid Organs of the Mouse....Pages 171-175
Human Lymphatic Microecology — Specificity, Characterization and Ontogeny of Different Reticulum Cells in the B Cell and T Cell Regions....Pages 177-182
‘Hyperlymphoid’ Mice....Pages 183-189
The Role of the Afferent Lymph in the Induction of Contact Sensitivity....Pages 191-196
Studies on the Effect of Environment on the GVH Reactivity of Recirculating Lymphocytes....Pages 197-202
The Recovery of the B Cell Compartment in Lethally Irradiated and Reconstituted Mice....Pages 203-208
Regulation of Thymic Lymphopoiesis in Vitro....Pages 209-214
Isolation and Partial Chemical Characterization of THF, A Thymus Hormone Involved in Immune Maturation of Lymphoid Cells....Pages 215-220
Regulation of Immune Balance by Thymosin: Potential Role in the Development of Suppressor T-Cells....Pages 221-228
Lymphoid Tissue Architecture. III. Germinal Centers, T Cells, and Thymus-Dependent vs Thymus-Independent Antigens....Pages 229-237
Summary and Afterthoughts on Session 3: Homing of Cells and Inductive Effects of Microenvironment and of Humoral Factors....Pages 239-244
Front Matter....Pages 245-245
Cell Interactions in Immune Responses: Role of T Lymphocytes....Pages 247-252
Induction of Hapten Recognizing Helper Function by Heavily Trinitrophenylated Sheep Erythrocytes....Pages 253-260
 In Vitro Proliferative Reactions by Lymphocytes from both Responder and “Low” Responder Mice to (T, G)-A—L....Pages 261-266
Effect of Interaction between Hapten-Specific Cells Preselected for Different Receptor Affinities and Carrier-Primed Cells on Antibody Avidity....Pages 267-271
Front Matter....Pages 245-245
Cell Interaction in B/W Mice: A Reversible Defect at the T-Cell Level....Pages 273-282
T-cell Dependency of the Response to PVP is Dependent on Maturity of B-cells....Pages 283-288
Differentiation of Cytotoxic T Lymphocytes Enhanced by T Cell Factors Produced during Mixed Lymphocyte Interactions....Pages 289-294
Enhancing Effect of Radioresistant Spleen Cells on the Primary Immune Response against Sheep RBC by Mouse Spleen Cells in Vitro....Pages 295-299
Effector Cell Requirements for Antibody-Dependent and Mitogen-Induced Cytotoxicity....Pages 301-306
Recruitment of Effector Lymphocytes by Initiator Lymphocytes: Recruited Lymphocytes are Immunospecific....Pages 307-311
Histophysiology of the Helper T Cell System in Rabbits....Pages 313-318
Interference of Cyclophosphamide with the Development of T Helper Activity in Rabbits....Pages 319-324
Enhanced in Vitro Immunogenicity of H-2 Antigens in the Presence of Ia Antigens....Pages 325-329
Co-Operation is the Thing....Pages 331-333
Front Matter....Pages 335-335
Lymphoid Cell Receptors and Antigen Recognition....Pages 337-341
Patterned Antigen-Binding Cells of Multiple Specificity....Pages 343-348
Evidence for Two Antibody Molecules of Different Specificity Secreted by Bispecific Mouse Spleen PFC Micromanipulated “in vitro”....Pages 349-353
Early Events in the Generation of Antigen-Specific Cytotoxicity in MLC....Pages 355-360
A Study on the Immunological Function of Fc Receptor-Bearing Cells among Activated Thymocytes....Pages 361-366
Relation of Antigen-Binding Cells to Immunological Memory....Pages 367-372
The Detection of IgD and IgM on Murine B-Lymphocytes in Conditions where no Ig can be Found on T-Lymphocytes....Pages 373-379
The Influence of “I” Region Antibodies on Transplants....Pages 381-386
Virus-Immune Cytotoxic T Cells are Sentized to by Virus Specifically Altered Structures Coded for in H-2K or H-2D: A Biological Role for Major Histocompatibility Antigens....Pages 387-389
Restriction by H-2 Gene Complex of the Transfer of Delayed Type Hypersensitivity in Mice....Pages 391-396
Front Matter....Pages 335-335
Characterization and Specificity of a T-Cell Cooperative Factor....Pages 397-402
Rat Anti-Lymphocyte Alloantibodies Block Con A-Stimulation of T Lymphocytes: Inhibition of a Polyclonally Specific T Cell Reaction....Pages 403-408
Recognition of Antigen by B and T Lymphocytes....Pages 409-412
Front Matter....Pages 413-413
Host Protection by the Antibody-Forming System in Malignancy....Pages 415-421
Tumour Resistance of Tetraparental AKR↔CBA Chimaeras....Pages 423-429
Low Numbers of Tumor Cells Suppress the Host Immune System....Pages 431-436
Studies on Effector Cell — Target Cell Interactions in Vitro by Means of the Quantitative Immunoadherence Technique....Pages 437-443
Immunologic Responses of the Autochthonous Host against Tumors Induced by Ultraviolet Light....Pages 445-449
The In Vivo Coating of Tumor Cells by Potentially Cytotoxic Antitumor Antibodies....Pages 451-456
Modulation of the Immune Response in Vitro and in Vivo by Splenocytes from Tumor-Bearing Mice....Pages 457-463
Divalent Cation Requirements as a Tool for the Study of Cell-Mediated Cytotoxicity Systems....Pages 465-470
Macrophage Killing Capacity. Aspects of Mechanism....Pages 471-476
A New T Cell Neoplasm Expressing Surface Anti-DNP Activity, Developed from the Thymus of Mice Bearing MOPC-315 Plasma Cell Tumors....Pages 477-481
Lymphocyte-Target Cell Conjugation: Membrane Receptors for Alloantigens....Pages 483-488
Observations in Vitro Regarding the Mechanism of the Cell Destruction by Stimulated Lymphocytes....Pages 489-494
The Presence of Cells Expressing Immune-Complex Receptors in Non-Lymphoid Murine Tumors....Pages 495-500
T and B Immunodepression during 7,12-Dimethylbenz(α) Anthracene (DMBA) Carcinogenesis in Mice....Pages 501-506
Reversal of a Leukemia Virus-Induced Immunodepression by Macrophages in Vitro and in Vivo ....Pages 507-512
Tumor Immunology—Interaction between Lymphocytes, Antibodies and Neoplastic Cells: A Summary....Pages 513-517
Front Matter....Pages 519-519
IR Genes, Phenotypic Expressions and their Interpretation....Pages 521-526
Front Matter....Pages 519-519
T Helpers may be Sensitized by Antigen-Specifically Altered Structures, which are Coded by the I Region of the H-2 Gene Complex....Pages 527-530
Multigenic I Region Control of the Immune Responses of Mice to the GLØ and GLT Random Terpolymers....Pages 531-536
Overcoming Ir Gene Control of the Response to the Lysozymes....Pages 537-543
Genetic Control of the Immune Response to Ordered Peptides of Tyrosine and Glutamic Acid....Pages 545-546
Antigen Specific T Cell Factors in the Genetic Control of the Immune Response to Poly(Tyr, Glu)-Poly(Pro)—Poly(Lys)....Pages 547-549
A Model for Genetic Control of the Immune Response....Pages 551-553
Front Matter....Pages 555-555
The Role of Suppression in Immunoregulation....Pages 557-563
Immunosuppression by Fetal Liver as a Model for Tolerance to Self....Pages 565-569
Suppressor Cells in the Embryonic Thymus Mediate Allograft Tolerance....Pages 571-576
Tolerance in Tetraparental Mouse Chimaeras....Pages 577-583
Studies on Suppressor T Cells in Tolerance....Pages 585-592
Depletion of Suppressor T-Cells in Syngeneic Chimeric Mice....Pages 593-598
Regulatory Cells in the Bone Marrow....Pages 599-605
Suppression by Soluble Factor Released from B Cells....Pages 607-615
The Regulatory Influence of the Thymus-Dependent Immune System on the Heterogeneity of Immunoglobulins in Irradiated and Reconstituted Mice....Pages 617-621
Interference with Antibody-Feedback by Irradiation, Thymus Cells, the Allogeneic Effect, and Serum Factors....Pages 623-633
Effect of Chorionic Gonadotropins on Humoral and Cell—Mediated Immunity....Pages 635-638
Augmentation of Cell Mediated Lysis (CML) by THF....Pages 639-643
Concluding Remarks to Session Eight: Suppressor Cells and Enhancing Antibodies: Immune Agents of the Facilitation Reaction....Pages 645-648
Front Matter....Pages 649-649
Immunopathology....Pages 651-652
Front Matter....Pages 649-649
Lymphocyte Surface-Attached Immunoglobulins in Some Clinical Conditions....Pages 653-658
Control of Autoimmune Processes by a Thymic Humoral Factor (THF)....Pages 659-664
Clinical, Immunological and Histopathological Evidence for Thymic Deficiency in Down’s Syndrome (Mongolism)....Pages 665-671
Immunomorphological Lymph Node Processes in Some Cirrhogenic Liver Diseases....Pages 673-678
Casein-Induced Murine Amyloidosis: Amyloid and Immunoglobulin Production and Proliferative Capacity of Splenocytes....Pages 679-684
T and B Blocking Factors in Hodgkin’s Disease....Pages 685-690
Properties of Transplantable Reticulum Cell Sarcomas in SJL/J Mice....Pages 691-697
Skin as a Vehicle for Horizontal Transmission of Gross Passage a Leukemia in Adult Mice. A Unique Microenvironment?....Pages 699-704
The Relationship between Phagocytosis, Release of Lysosomal Enzymes and 3’, 5’ Cyclic Adenosine Monophosphate in Mouse Macrophages 1)....Pages 705-710
The Still Unsolved Germinal Centre Mystery (Invited Lecture)....Pages 711-723
Back Matter....Pages 725-732