Immune Mechanisms in Renal Disease

Front Matter....Pages i-xxviii
Functional Organization of the Glomerulus: Presence of Glycosaminoglycans (Proteoglycans) in the Glomerular Basement Membrane....Pages 1-35
Mechanisms of Glomerular Permselectivity....Pages 37-45
The Molecular Structure of Basement Membranes as It Relates to Function....Pages 47-69
Glomerular Basement Membrane Antigens....Pages 71-81
Physiologic Approaches to the Mechanisms of Glomerular Immune Injury....Pages 83-94
Physical Interactions between Macromolecules and the Glomerular Filter....Pages 95-107
Pathologic and Functional Correlations in the Glomerulopathies....Pages 109-127
Glomerular Mesangium: Introductory Remarks....Pages 129-139
The Influence of Hemodynamic Factors upon Mesangial Kinetics of Macromolecules....Pages 141-150
Deposition and Removal of Glomerular Immune Complexes: Relationships to the Mononuclear Phagocyte System....Pages 151-165
LCM Virus Infection and Nephritis....Pages 167-178
Diabetic Nephropathy: Relevance of Animal Models to the Understanding of Pathological Processes in Immune Renal Disease....Pages 179-188
Characterization of Rat Glomerular Cells in Vitro....Pages 189-200
Culture of Human Glomerular Cells....Pages 201-212
Immunochemical and Biochemical Studies of Human Glomerular Cells in Culture....Pages 213-224
Results of Immune Complex Detection in Human Glomerular Diseases....Pages 225-231
Nephritogenic Immune Responses Involving Basement Membrane and Other Antigens in or of the Glomerulus....Pages 233-248
Autoimmune Disease Induced in Rabbits by Administration of Mercuric Chloride: Evidence Suggesting a Role for Antigens of the Connective Tissue Matrix....Pages 249-260
Experimental Autoimmune Renal Tubulointerstitial Disease....Pages 261-278
Experimental and Human Anti-Tubular Basement Membrane Nephritis....Pages 279-294
Autoimmunity to Tamm-Horsfall Protein....Pages 295-304
Renal Antigens in Experimental Immune Complex Glomerulonephritis....Pages 305-318
Mechanisms of Proteinuria Induced by Antikidney Antibodies in Noninflammatory Experimental Glomerulonephropathy....Pages 319-335
The Pathogenesis of Autologous Immune Complex Glomerulonephritis in Rats....Pages 337-348
Immunopathogenesis of Murine SLE....Pages 349-355
Studies on Detection of Nephritogenic Immune Complexes....Pages 357-361
The Significance of Cryoimmunoglobulinemia in Immunologically Mediated Kidney Diseases....Pages 363-370
Relationship of Serum Cryoglobulins and Their Composition to Glomerulonephritis in Systemic Lupus Erythematosus....Pages 371-382
Cryoprecipitable Immunoglobulins with Native DNA Reactivity in the Glomerulopathies....Pages 383-397
The Role of Streptococcal and Glomerular Basement Membrane Antigens in Glomerulonephritis....Pages 399-418
The Contact (Hageman Factor) System in Inflammation....Pages 419-432
The Function of the Reticuloendothelial System in Autoimmune Disease....Pages 433-441
A Role of Mononuclear Phagocytes in Immunologically Induced Glomerulonephritis....Pages 443-451
Genetic Structure of the HLA Region and Implication for Function....Pages 453-465
Genetic Defects of the Complement Pathways: Relationship to HLA and Disease....Pages 467-473
Complement Abnormalities in Allergy and the Nephrotic Syndrome....Pages 475-479
Immunogenetic Aspects of Glomerulonephritis....Pages 481-488
Autoantibodies in Systemic Lupus Erythematosus....Pages 489-498
Serological Studies of Antibodies Reactive with RNA and RNA-Protein Antigens....Pages 499-512
Modulation of Autoimmunity by Sex Hormones....Pages 513-516
Thymic and T-Cell Function in Murine and Human Lupus....Pages 517-527
Immune Regulatory Abnormalities in Systemic Lupus Erythematosus....Pages 529-548
Addendum....Pages 565-565
Back Matter....Pages 549-564