Idiopathic Dilated Cardiomyopathy: Cellular and Molecular Mechanisms, Clinical Consequences

Front Matter....Pages I-XVI
Front Matter....Pages 1-1
Idiopathic Dilated Cardiomyopathy: Current Concepts in Clinical Research....Pages 3-9
Front Matter....Pages 11-11
Epidemiology of Idiopathic Dilated Cardiomyopathy....Pages 13-25
Natural History of Idiopathic Dilated Cardiomyopathy....Pages 26-42
Front Matter....Pages 43-43
Molecular Analysis of Cardiac Growth and Development in Transgenic Mouse Model Systems....Pages 45-55
The Promoter of the Human Cardiac β -Myosin Heavy-Chain Gene Is Controlled by an Upstream Enhancer....Pages 56-64
Growth Factor Expression in the Cardiac Myocyte....Pages 65-72
Front Matter....Pages 73-73
The Cytoskeleton and Extracellular Matrix in Human Hearts with Dilated Cardiomyopathy....Pages 75-80
Macro- and Micropathology of Dilated Cardiomyopathy....Pages 81-87
Detection of Disruption of Sarcolemmal Membrane by Indium-111 Labeled Antimyosin Antibody Scan....Pages 88-96
Extracellular Matrix Expression, Organization, and Interaction with Heart Myocytes During Development and Disease....Pages 97-108
Front Matter....Pages 109-109
Ventricular Remodeling in Idiopathic Dilated Cardiomyopathies....Pages 111-119
Mechanisms of Deficient cAMP Generation in Heart Failure....Pages 120-131
Abnormal Calcium Metabolism in Heart Muscle Dysfunction....Pages 132-144
Energy Requirements of Contraction and Relaxation of the Heart....Pages 145-152
Front Matter....Pages 153-153
Capillary Density, Distribution, and Length Parameters Related to Oxygen Supply in Myocardial Hypertrophy and Atrophy....Pages 155-164
Microcirculation in the Cardiomyopathic Syrian Hamster and in Human Congestive Cardiomyopathy....Pages 165-175
The Microcirculation in Cardiac Hypertrophy....Pages 176-184
Myocardial Oxygen Consumption in Patients with Idiopathic Dilated Cardiomyopathy: Effects of Vasodilating and Inotropic Agents....Pages 185-194
Regression of Cardiac Hypertrophy with Pharmacotherapeutic Regimen....Pages 195-206
Front Matter....Pages 207-207
 β -Adrenergic Receptor Dysfunction in the Pathogenesis of Idiopathic Dilated Cardiomyopathy....Pages 209-221
Front Matter....Pages 207-207
Na + Channels as Molecular Substrate of Cardiac Excitability: Elementary Properties and Responsiveness to Drugs....Pages 222-233
The Involvement of G s in Regulation of the L-Type Voltage-Gated Ca 2+ Channel....Pages 234-249
Inositol Phosphates in Cardiac Regulation....Pages 250-264
Front Matter....Pages 265-265
Enterovirus-Induced Cardiomyopathy: Molecular Analysis of Acute and Persistent Myocardial Infections....Pages 267-283
Direct Damage of Myocardium by Enterovirus....Pages 284-293
Natural History of Enterovirus Persistence in the Murine Model of Coxsackievirus-Induced Myocarditis: A Quantitative In Situ Hybridization and Immunohistochemistry Study....Pages 294-300
Detection and Typing of Enteroviruses....Pages 301-309
Specific and Nonspecific Heart Defenses in Enteroviral Infections....Pages 310-321
Front Matter....Pages 323-323
Heart Autoantibodies in Human Myocarditis and Cardiomyopathy: Virus and Skeletal Muscle Cross-reactivity....Pages 325-334
Are Anti-cardiac Antibodies in Dilated Cardiomyopathy “Natural” Antibodies?....Pages 335-348
Front Matter....Pages 349-349
Animal Models for Therapeutic Trials of Viral Myocarditis....Pages 351-362
Immunosuppressive Therapy in Human Myocarditis....Pages 363-368
Interferon Therapy in Enterovirus-Associated Idiopathic Dilated Cardiomyopathy....Pages 369-372
The Role of β -Blockers in Idiopathic Dilated Cardiomyopathy: Clinical Effect and Molecular Mechanism....Pages 373-381
The Role of Calcium Channel Blockers in Idiopathic Dilated Cardiomyopathy....Pages 382-389
Gene Therapy for Cardiovascular Disease: Realistic Possibilities for the Future....Pages 390-395
Back Matter....Pages 397-405