Hyaluronan Signaling and Turnover, Volume 123

 Content: Front Cover; Hyaluronan Signaling and Turnover; Copyright; Contents; Contributors; Preface; Chapter One: Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy; 1. Introduction; 2. Of Mole Rats and Men: Insights About HA and Cancer; 2.1. HA and hyaluronidase accelerate human cancers; 2.2. Naked mole rats resist cancer; 3. Hyaluronidase Expression in Cancer; 3.1. Hyal1; 3.2. Hyal2; 3.3. Hyal3, Hyal4, and PH-20; 4. Hyaluronidase Function and the Metastatic Process; 4.1. Vesicle trafficking and cell motility; 4.2. Vesicle shedding. 4.3. Products of hyaluronidase: Fragments versus oligos4.4. Products of hyaluronidase: Beyond HA; 5. Hyaluronidase Targeting in Cancer Therapy and Imaging; 5.1. Structural and functional features of human Hyals; 5.2. Targeting of hyaluronidase for cancer therapy; 5.3. Hyaluronidase-targeting agents for tumor imaging; 6. Conclusions and Future Perspective; Acknowledgments; References; Chapter Two: Targeting Hyaluronic Acid Family for Cancer Chemoprevention and Therapy; 1. Introduction; 2. Targeting HA Production; 2.1. Targeting HA synthases; 2.2. Chemical inhibitors of HA synthesis. 2.2.1. 4-Methylumbelliferone2.2.2. Other HA synthesis inhibitors; 3. Targeting HA Signaling; 3.1. HA oligosaccharides; 4. HA as a Carrier for Drug Delivery; 5. Targeting HA Receptors; 5.1. CD44; 5.1.1. CD44 vaccines; 5.1.2. CD44 siRNA delivery; 5.1.3. Targeting CD44 for delivering antitumor therapies; 5.1.4. Targeting of CD44 protein; 5.2. RHAMM; 6. Targeting HAase; 7. Conclusion; Acknowledgments; References; Chapter Three: Aberrant Posttranscriptional Processing of Hyaluronan Synthase 1 in Malignant Transformation and Tumor Prog ... ; 1. Splicing and Cancer; 1.1. Splicing in the human genome. 2. Control of Pre-mRNA Splicing2.1. Splicing mutations; 3. Impact on Cancer of Alterations in Splicing Machinery; 4. Aberrant Splicing of Hyaluronan Synthase 1; 4.1. B lineage malignancies; 4.1.1. Multiple myeloma; 4.1.2. Waldenstrom macroglobulinemia; 4.2. Aberrant splice variants in hyaluronan synthase 1; 5. Clinical Impact of Aberrant HAS1 Splicing; 6. Genetic Variations in HAS1; 7. Functional Impact of HAS1Vs; 7.1. Synthesis of HA; 7.2. Functional outcomes of HA synthesis in patients; 7.2.1. Motility and malignant spread; 7.2.2. HAS1Vs and oncogenic events. 7.2.3. Intermolecular interactions of HAS1Vs7.2.4. HAS1Vs and genetic instability; 8. Functional Outcomes of HAS1Vs in Transfectants; 8.1. HAS1Vs synthesize intracellular HA; 8.2. HAS1FL and HAS1Vs form heteromultimers with HAS1Vs as the dominant partners; 8.3. Multimers with HAS1Vs stabilize HAS1FL and maintain intracellular HA; 9. HAS1Vs and Mitotic Catastrophe; 9.1. A potential mechanism underlying the oncogenic properties of aberrant HAS1 splice variants: HAS1V-mediated rescue fro ... ; 9.1.1. Receptor for hyaluronan-mediated motility (RHAMM).