Human Apolipoprotein Mutants: Impact on Atherosclerosis and Longevity

Front Matter....Pages i-xii
The Function of Human Serum Apolipoproteins: Clues from Inborn Errors of Lipoprotein Metabolism....Pages 1-16
DNA Polymorphisms and Analysis of Hyperlipidaemia....Pages 17-24
Monoclonal Antibodies and Genetic Polymorphism of Apolipoproteins....Pages 25-30
Normal Genetic Lipoprotein Variations and Atherosclerosis....Pages 31-49
Epidemiology of Lipids and Lipoproteins as a Guide to the Detection of Mutants....Pages 51-54
Detection and Genetic Handling of Mutants....Pages 55-59
AI Milano — History and Clinical Profile....Pages 61-70
Apolipoprotein AI-Milano: A Structural Modification in an Apolipoprotein Variant Leading to Unusual Lipid Binding Properties....Pages 71-82
The AI-Milano HDL Particles....Pages 83-93
Apolipoprotein A-I Milano : In Vivo Metabolism of an Apolipoprotein A-I Variant....Pages 95-98
The Limone Sul Garda Gene....Pages 99-102
Immunological Characterization of Apolipoprotein AI from Normal Human Plasma: Mapping of Antigenic Determinants....Pages 103-117
Lipid Binding Properties of Human Apo Al Mutants....Pages 119-127
Recent Studies on the Metabolic Defect in Tangier Disease....Pages 129-132
Apolipoprotein A-I and A-II Metabolism in Subjects with Coronary Heart Disease (CHD)....Pages 133-138
An Apoprotein AII Gene Polymorphism and Hyperlipidaemia....Pages 139-142
Analysis of Apolipoprotein A-I Synthesized in Vitro from Chick Intestinal mRNA....Pages 143-152
Versatile E. coli Expression-Modification Vectors as Tools for Structure-Function Studies of Apolipoprotein Al....Pages 153-160
Selection of Monoclonal Antibodies as Probes for the Study of Genetic Polymorphism of LDL Apo B....Pages 161-167
Structure-Function Studies of Apolipoprotein B100 and the Search for Mutants....Pages 169-178
Immunoblot Analysis of the Different Apolipoprotein B Species....Pages 179-185
Apolipoprotein C-II Deficiency....Pages 187-195
Familial Apolipoprotein CII Deficiency: An Analysis of the Gene Defect in a Dutch Family....Pages 197-202
Apo C-II Padova : A New Apoprotein Variant in Two Patients with Apo C-II Deficiency Syndrome....Pages 203-210
The Apolipoprotein E Gene: Chromosomal Localization and Tissue Expression....Pages 211-215
Apoprotein E3-Leiden: A Variant of Human Apolipoprotein E3 Associated with Familial Type III Hyperlipoproteinemia....Pages 217-222
Recent Studies on the Molecular Defect in Apolipoprotein E Deficiency....Pages 223-227
Back Matter....Pages 229-233