HLA Class II Antigens: A Comprehensive Review of Structure and Function

Front Matter....Pages I-XVII
Genes and Antigens of the HLA-D Region....Pages 1-13
Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression....Pages 14-31
Epitopes Are the Functional Units of HLA Class II Molecules and Form the Molecular Basis for Disease Susceptibility....Pages 32-48
Structure of Human Class II Antigens Expressed by a Homozygous Lymphoblastoid B Cell Line....Pages 49-70
The Complexity of HLA-DQ Molecules....Pages 71-82
HLA-DP: Current Status....Pages 83-108
Structural and Functional Studies of Mouse Class II Genes....Pages 109-127
Cross-reactions of Class II Histocompatibility Antigens of Various Species....Pages 128-153
Human Class II Antigen in Different Ethnic Groups....Pages 154-168
Serology of HLA Class II Antigens: Methodological Aspects....Pages 169-186
Alloantisera Against Human Class II Antigens: Definition and Methodology....Pages 187-203
Monoclonal Antibodies Against HLA Class II Antigens....Pages 204-223
Preparation, Characterization, and Utilization of Monoclonal Antibodies to the Gene Products of the HLA-D Region, with Special Emphasis on Those to Polymorphic Determinants....Pages 224-248
Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-D....Pages 249-265
Cellular Detection of Human Class II MHC Antigens by Alloreactive T Cell Clones....Pages 266-280
Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferative T Cell Clones....Pages 281-298
Modulation of Class II Antigens by Interferons....Pages 299-313
Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects....Pages 314-338
Tissue Distribution of Class II Transplantation Antigens: Presence on Normal Cells....Pages 339-355
Class II MHC Antigens on Human Monocytes, Endothelial Cells, and Dendritic Cells....Pages 356-373
Class II Antigens: T Cells....Pages 374-385
Class II MHC Antigens and Hematopoiesis....Pages 386-401
Class II MHC Antigens and Erythropoiesis....Pages 402-411
Expression of Class II Antigens on Nonhematopoietic Tumor Cells....Pages 412-428
Class II HLA Antigens in Benign and Malignant Lesions of Melanocytic Origin....Pages 429-441
Molecular Polymorphism of Human Immune-Response-Genes....Pages 442-459
Molecular Genetics as a Tool in Clinical Transplantation....Pages 460-472
The Role of Human Class II Molecules in Activation of T4 Lymphocytes....Pages 473-488
Class II HLA Antigens in Autoimmune and Immune-Mediated Diseases....Pages 489-514
The Role of HLA Class II Antigens in Clinical Transplantation....Pages 515-529
Relevance of HLA-D/-DR Matching in a National Kidney Transplant Program....Pages 530-540
The Pig as a Model to Assess the Effect of Class II MHC Antigen Matching on Renal Allograft Survival....Pages 541-556
Back Matter....Pages 557-563