Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

Front Matter ....Pages i-xvii
 Overview of Epigenetic Signatures and Their Regulation by Epigenetic Modification Enzymes  (Shabir Ahmad Ganai)....Pages 1-33
 Epigenetic Regulator Enzymes and Their Implications in Distinct Malignancies  (Shabir Ahmad Ganai)....Pages 35-65
 Summa of Erasers of Histone Acetylation with Special Emphasis on Classical Histone Deacetylases (HDACs)  (Shabir Ahmad Ganai)....Pages 67-74
 Strong Involvement of Classical Histone Deacetylases and Mechanistically Distinct Sirtuins in Bellicose Cancers  (Shabir Ahmad Ganai)....Pages 75-95
 Recap of Distinct Molecular Signalling Mechanisms Modulated by Histone Deacetylases for Cancer Genesis and Progression  (Shabir Ahmad Ganai)....Pages 97-110
 Compendium of Mechanistic Insights of Distinct Conventional Anticancer Therapies and Their Grievous Toxicities  (Shabir Ahmad Ganai)....Pages 111-136
 Modulating Epigenetic Modification Enzymes Through Relevant Epidrugs as a Timely Strategy in Anticancer Therapy  (Shabir Ahmad Ganai)....Pages 137-157
 Conspectus of Structurally Distinct Groups of Histone Deacetylase Inhibitors of Classical Histone Deacetylases and Sirtuins  (Shabir Ahmad Ganai)....Pages 159-171
 Singlet Anticancer Therapy Through Epi-Weapons Histone Deacetylase Inhibitors and Its Shortcomings  (Shabir Ahmad Ganai)....Pages 173-201
 Combining Histone Deacetylase Inhibitors with Other Anticancer Agents as a Novel Strategy for Circumventing Limited Therapeutic Efficacy and Mitigating Toxicity  (Shabir Ahmad Ganai)....Pages 203-239
 Futuristic Approaches Towards Designing of Isozyme-Selective Histone Deacetylase Inhibitors Against Zinc-Dependent Histone Deacetylases  (Shabir Ahmad Ganai)....Pages 241-258