Hepatocellular Carcinoma: Translational Precision Medicine Approaches

Front Matter ....Pages i-xv
Front Matter ....Pages 1-1
 Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care  (Naoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida)....Pages 3-25
 Hepatocellular Carcinoma Surveillance and Staging  (Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai)....Pages 27-51
 Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance  (Yueran Zhuo, Qiushi Chen, Jagpreet Chhatwal)....Pages 53-67
Front Matter ....Pages 69-69
 Radiological Diagnosis and Characterization of HCC  (Naik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli)....Pages 71-92
 Analysis of Hepatocellular Carcinoma Tissue for Biomarker Discovery  (Connor A. West, Alyson P. Black, Anand S. Mehta)....Pages 93-107
 Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision-Making  (Sung Hwan Lee, Sun Young Yim, Jae-Jun Shim, Ju-Seog Lee)....Pages 109-123
 Liquid Biopsy in Hepatocellular Carcinoma  (Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting)....Pages 125-141
Front Matter ....Pages 143-143
 Surgical Therapies in Hepatocellular Carcinoma  (Caitlin A. Hester, Adam C. Yopp)....Pages 145-167
 Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began to Where We Are Going  (Patrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin)....Pages 169-194
 Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy  (Ryosuke Tateishi, Naoto Fujiwara)....Pages 195-224
 Molecular-Targeted Therapies in Hepatocellular Carcinoma  (Amit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard D. Kim)....Pages 225-238
 Immune Therapies  (Zachary J. Brown, Tim F. Greten)....Pages 239-253
 Prevention Strategies for Hepatocellular Carcinoma  (Derek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. Fuchs)....Pages 255-289
Front Matter ....Pages 291-291
 Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma  (Man Hsin Hung, Xin Wei Wang)....Pages 293-316
 Stromal and Immune Drivers of Hepatocarcinogenesis  (Antonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger et al.)....Pages 317-331
 Experimental Models for Preclinical Research in Hepatocellular Carcinoma  (Pedro Molina-Sánchez, Amaia Lujambio)....Pages 333-358
Back Matter ....Pages 359-364