Heparin and Related Polysaccharides

Front Matter....Pages i-x
Heparin — an Introduction....Pages 1-20
Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans....Pages 21-30
Structural Analysis of Periodate-Oxidized Heparin....Pages 31-36
New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins....Pages 37-47
Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis....Pages 49-57
Regulation of the Gene that Encodes the Peptide Core of Heparin Proteoglycan and Other Proteoglycans that are Stored in the Secretory Granules of Hematopoietic Cells....Pages 59-67
Structural and Functional Diversity of the Heparan Sulfate Proteoglycans....Pages 69-78
Syndecan — A Cell Surface Proteoglycan that Selectively Binds Extracellular Effector Molecules....Pages 79-85
Heparan Sulfate Proteoglycans and Signalling in Cell Adhesion....Pages 87-96
Animal Cell Mutants Defective in Heparan Sulfate Polymerization....Pages 97-106
Two Enzymes in One: N-Deacetylation and N-Sulfation in Heparin Biosynthesis are Catalyzed by the Same Protein....Pages 107-111
Metabolism of Plasma Membrane-Associated Heparan Sulfate Proteoglycans....Pages 113-120
Lysosomal Degradation of Heparin and Heparan Sulphate....Pages 121-134
Heparin Binding Properties of the Carboxyl Terminal Domain of [A 103,106,108 ] Antistasin 93–119....Pages 135-140
Heparin Protein Interactions....Pages 141-153
Role of Protein Conformational Changes, Surface Approximation and Protein Cofactors in Heparin-Accelerated Antithrombin-Proteinase Reactions....Pages 155-165
The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulfate Hexasaccharide....Pages 167-176
Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety....Pages 177-188
The Interaction Between LACI and Heparin....Pages 189-197
Tissue Factor Pathway Inhibitor and Heparin....Pages 199-204
LMW Heparin: Relationship Between Antithrombotic and Anticoagulant Effects....Pages 205-220
The Mode of Action of Heparins In Vitro and In Vivo....Pages 221-230
Prophylactically Effective Doses of Enoxaparin and Heparin Inhibit Prothrombin Activation....Pages 231-236
Pharmacokinetics of Heparin and of Dermatan Sulfate: Clinical Implications....Pages 237-247
Heparin in the Prevention and Treatment of Arterial Thromboembolism....Pages 249-258
Glycosaminoglycans in Prophylaxis Against Venous Thromboembolism....Pages 259-274
Treatment of Deep Vein Thrombosis (DVT) with Low Molecular Weight Heparins (LMWH)....Pages 275-281
Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin....Pages 283-295
Regulation of Protease Nexin-1 Activity by Heparin and Heparan Sulfate....Pages 297-306
New Approaches for Defining Sequence Specific Synthesis of Heparan Sulfate Chains....Pages 307-316
Modulation of Neovascularization and Metastasis by Species of Heparin....Pages 317-327
Anti-Inflammatory Effects of Heparin and its Derivatives Inhibition of Complement and of Lymphocyte Migration....Pages 329-340
Heparan Sulfate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus....Pages 341-353
Control of Angiogenesis by Heparin and Other Sulfated Polysaccharides....Pages 355-364
Back Matter....Pages 365-374