Hemodiafiltration - a New Era

Contents......Page 6
Preface......Page 10
First 60 Years (1914 – Early 1970s)......Page 12
Development of HDF......Page 13
The Current Status of HDF in Japan......Page 14
References......Page 15
Abstract......Page 16
Online Hemodiafiltration......Page 20
References......Page 26
Hemodiafiltration: From Origin to Today......Page 30
Techniques of Hemodiafiltration......Page 31
Mechanism of Hemodiafiltration......Page 34
Clinical Outcomes Achieved by HDF......Page 35
References......Page 37
Abstract......Page 39
Technical Prerequisite and Basic Hygienic Rules for ol-HDF......Page 40
Prerequisite and Technical Options of ol-HDF......Page 42
Handling and Microbial Monitoring of ol-HDF......Page 45
References......Page 46
Abstract......Page 50
Mortality......Page 51
Inflammation......Page 52
Health-Related Quality of Life......Page 56
Treatment Optimization Parameters......Page 58
References......Page 59
Abstract......Page 64
Classical Parameters for Prescribing a Dialysis Modality......Page 65
New Concept for Prescribing a Dialysis Modality......Page 66
Results of the Dialysis Prescription Based on the POD System......Page 67
Rationale of the New Concept for a Dialysis Prescription......Page 68
Practice Pattern for Prescribing Online HDF from a Case Study......Page 72
References......Page 73
Abstract......Page 75
Benefits of HDF over Low-Flux and High-Flux Hemodialysis......Page 78
Individualizing Choice of Renal Replacement Therapy......Page 80
Providing HDF at Home: Technical Considerations......Page 81
Dialysis Adequacy for Home HDF......Page 84
Acknowledgement......Page 85
References......Page 86
Abstract......Page 89
Online Preparation of Substitution Solution for Convective Therapies......Page 90
Components of a Quality Management System......Page 92
References......Page 98
Abstract......Page 100
Composition of Dialysis and Substitution Fluids......Page 101
Methods......Page 102
Results......Page 104
Discussion......Page 106
Conclusion......Page 107
References......Page 108
Central Dialysis Fluid Delivery System in Japan......Page 110
SPDM in Japan......Page 113
Substitution Fluid for Online HDF with CDDS and SPDM......Page 114
Maintenance of Purification of Dialysis Fluid......Page 115
HD and/or Online HDF Using SPDM by Comprehensive Management......Page 116
References......Page 117
Abstract......Page 118
Outline of the Central Dialysis Delivery System......Page 119
Fully Automated Dialysis System......Page 120
Dialysis Fluid Quality Control Standards......Page 122
Fluid Quality Control Method......Page 125
Discussion......Page 126
References......Page 127
Abstract......Page 128
Toxicity of Specific Uremic Retention Solutes......Page 129
Removal of Protein-Bound Uremic Solutes and Middle Molecules......Page 134
Interventional Outcome Studies Based on Removal......Page 136
References......Page 137
β2-Microglobulin and Dialysis-Related Amyloidosis......Page 140
Therapeutic Approaches......Page 141
References......Page 143
Abstract......Page 145
Oxidative Stress and AGEs in ESRD......Page 146
Clinical Effects of Vitamin E-Coated Dialyzer......Page 147
References......Page 148
Abstract......Page 150
Platelet Activation......Page 152
Monocyte Activation......Page 153
Neutrophil Activation......Page 155
References......Page 156
Abstract......Page 157
Results and Discussion......Page 159
References......Page 162
Abstract......Page 164
Materials and Methods......Page 165
Results......Page 168
Conclusions......Page 171
References......Page 172
Abstract......Page 173
Pathogenesis of Anemia in Chronic Kidney Disease......Page 174
Anemia and Dialysis Dose......Page 175
Convective Treatments......Page 176
Online Treatments......Page 177
References......Page 181
Abstract......Page 184
Influence of the Low Prevalence of Renal Transplantation on Chronic HD Therapy in Japan......Page 185
Impacts of High-Flux Membrane Dialyzers on Clinical Indices of HD Patients......Page 186
Impacts of HDF on the Clinical Indices of HD Patients......Page 188
References......Page 189
Abstract......Page 190
Development of Protein-Permeable Dialysis Membrane......Page 191
Removal of Uremic Substances and Loss of Albumin in Low MW Protein Region......Page 192
Clinical Efficiency......Page 193
Conclusion......Page 196
References......Page 198
Concept of Acetate-Free Biofiltration......Page 199
Indication for AFB......Page 200
AFHD vs. AFB......Page 201
Conclusion......Page 203
References......Page 204
Abstract......Page 206
Evaluation of Autonomic Function by NICOMM......Page 207
Stability Index of Tissue Blood Flow in the Head......Page 209
Evaluation of Blood Purification Modalities with the Head SI......Page 210
Conclusions......Page 213
References......Page 214
Background......Page 215
Study 1......Page 216
Study 2......Page 217
Study 3......Page 218
Discussion......Page 221
References......Page 222
Author Index......Page 224
Subject Index......Page 225