Heart Hypertrophy and Failure

Front Matter....Pages i-xli
Front Matter....Pages 1-1
Molecular Analysis of Genotype/Phenotype Correlations of Hypertrophic Cardiomyopathy....Pages 3-19
Molecular Genetics: New Mutations that Cause Familial Hypertrophic Cardiomyopathy....Pages 21-25
Genetically Determined Cardiomyopathies in Neuromuscular Diseases....Pages 27-38
Mitochondrial DNA Mutations and Heart Failure....Pages 39-58
Mutations of Myocardial Mitochondrial DNA in Diabetic Patients....Pages 59-66
Differential Screening and Megasequencing of Human Heart cDNA Library: A Search for Genes Associated with Heart Failure....Pages 67-77
Intracellular Signaling and Genetic Reprogramming During Development of Hypertrophy in Cultured Cardiomyocytes....Pages 79-92
Phenotypic Changes in Experimental Cardiac Hypertrophy and Failure in Relation to Changes in Heart Rate Variability....Pages 93-101
Relationship Between Myocardial Function and Expression of Calcium Cycling Proteins in Nonfailing and Failing Human Myocardium....Pages 103-116
Cardiac Remodeling by Alterations in Phospholamban Protein Levels....Pages 117-137
Regulation of Sarcoplasmic Reticulum Gene Expression during Cardiac Hypertrophy and Heart Failure....Pages 139-154
Hormonal Regulation of Cardiac Sarcoplasmic Reticulum Ca 2+ -ATPase Expression....Pages 155-168
Front Matter....Pages 169-169
Growth of the Neonatal Pig Heart....Pages 171-182
Regulation of Cardiac Myocyte Differentiation, Hyperplasia, and Hypertrophy During Normal and Stressed Fetal and Neonatal Growth....Pages 183-195
Rat Heterotopic Cardiac Isograft Model: What Atrophy Teaches Us about Hypertrophy....Pages 197-204
Myocardial Cell Abnormalities in Heart Failure: Experience from Studies on Single Myocytes....Pages 205-219
Depression of Sarcolemmal Phospholipase C Activity in Congestive Heart Failure....Pages 221-229
Does Decreased Energy Supply Contribute to Heart Failure? The Role of the Creatine Kinase System....Pages 231-239
Molecular Basis for Depressed Contractile Performance in Human Heart Failure....Pages 241-255
Cellular Adaptations in Hypertrophy and Heart Failure....Pages 257-260
Front Matter....Pages 169-169
Progressive Ventricular Dilatation in Heart Failure: The Role of Myocardial Collagenase....Pages 261-273
Interaction Between Cardiac Myocytes and the Extracellular Matrix in Failing Human Myocardium....Pages 275-285
Role of Transforming Growth Factor Beta 1 in the Remodeling of Collagen Matrix in the Heart....Pages 287-297
Cytokines Modulate the Expression of Specific Proteins of the Contractile Apparatus in Rat Myocytes....Pages 299-307
Front Matter....Pages 309-309
Rethinking Ras: p21 Ras Proteins and Cardiac Signal Transduction....Pages 311-331
Regulation of αMHC Gene Expression by cAMP....Pages 333-346
Cardiac Hypertrophy and the Renin-Angiotensin System....Pages 347-358
Stimulation of β-Adrenoceptor Subtypes Causes Different Effects in Cardiac Cells....Pages 359-380
Significance of Adrenergic Stimuli for Cardiac Remodeling under Chronic Overload: Relative Importance of Myocardial Factors versus Ventricular Geometry in Cardiac Failure....Pages 381-402
Sympathetic Neuroeffector Mechanisms in the Failing and Hypertrophied Myocardium....Pages 403-417
Status of Post Adrenergic Receptor Mechanisms in Cardiac Hypertrophy and Heart Failure....Pages 419-446
Role of Protein Kinase C in the Development of Non-Insulin-Dependent Diabetic Cardiomyopathy....Pages 447-462
The Alteration of Signal Transduction System in Heart Failure: Renin-Angiotensin System in Diseased Human Heart....Pages 463-473
Neuroendocrine Mechanisms in the Pathogenesis of Heart Failure....Pages 475-486
Neurohormonal Responses in Congestive Heart Failure: Effect of Ace Inhibitors in Randomized Controlled Clinical Trials....Pages 487-501
Back Matter....Pages 503-531