Handbook of Cell Signaling

Content: 
Front-matter, Pages i,iii
Copyright, Page iv
Contributors, Pages xxi-xlii
Preface to the Second Edition, Page xliii, Ralph A. Bradshaw, Edward A. Dennis
Preface to the First Edition, Pages xlv-xlvi, Ralph A. Bradshaw, Edward A. Dennis
Chapter 1 - Cell Signaling: Yesterday, Today, and Tomorrow, Pages 1-4, Ralph A. Bradshaw, Edward A. Dennis
Part I. Initiation: Extracellular and Membrane Events, Pages 5-7, James A. Wells
Chapter 2 - Structural and Energetic Basis of Molecular Recognition, Pages 11-13, Emil Alexov, Barry Honig
Chapter 3 - Free Energy Landscapes in Protein–Protein Interactions, Pages 15-21, Jacob Piehler, Gideon Schreiber
Chapter 4 - Molecular Sociology, Pages 23-28, Irene M.A. Nooren, Janet M. Thornton
Chapter 5 - Antibody–Antigen Recognition and Conformational Changes, Pages 29-36, Robyn L. Stanfield, Ian A. Wilson
Chapter 6 - Binding Energetics in Antigen–Antibody Interfaces, Pages 37-40, Roy A. Mariuzza
Chapter 7 - Immunoglobulin–Fc Receptor Interactions, Pages 41-48, Jenny M. Woof
Chapter 8 - Ig-Superfold and its Variable Uses in Molecular Recognition, Pages 49-54, Nathan R. Zaccai, E. Yvonne Jones
Chapter 9 - T Cell Receptor/pMHC Complexes, Pages 55-62, Markus G. Rudolph, Robyn L. Stanfield, Ian A. Wilson
Chapter 10 - Mechanistic Features of Cell-Surface Adhesion Receptors, Pages 63-69, Steven C. Almo, Anne R. Bresnick, Xuewu Zhang
Chapter 11 - The Immunological Synapse, Pages 71-75, Michael L. Dustin
Chapter 12 - NK Receptors, Pages 77-84, Roland K. Strong
Chapter 13 - Carbohydrate Recognition and Signaling, Pages 85-91, James M. Rini, Hakon Leffler
Chapter 14 - Rhinovirus–Receptor Interactions, Pages 93-96, Elizabeth A. Hewat
Chapter 15 - HIV-1–Receptor Interactions, Pages 97-101, Peter D. Kwong
Chapter 16 - Influenza Virus Neuraminidase Inhibitors, Pages 103-110, Garry Taylor, Rupert Russell
Chapter 17 - Structural Basis of Signaling Events Involving Fibrinogen and Fibrin, Pages 111-114, Russell F. Doolittle
Chapter 18 - Structural Basis of Integrin Signaling, Pages 115-118, Robert C. Liddington
Chapter 19 - Structures of Heterotrimeric G Proteins and their Complexes, Pages 119-128, Stephen R. Sprang
Chapter 20 - G Protein-Coupled Receptor Structures, Pages 129-138, Veli-Pekka Jaakola, Raymond C. Stevens
Chapter 21 - Toll-Like Receptors–Structureand Signaling, Pages 139-143, Istvan Botos, David R. Davies
Chapter 22 - Variable Lymphocyte Receptors, Pages 145-148, Brantley R. Herrin, Max D. Cooper
Chapter 23 - Structure and Function of G-Protein-Coupled Receptors: Lessons from Recent Crystal Structures, Pages 151-156, Thomas P. Sakmar
Chapter 24 - Chemokines and Chemokine Receptors: Structure and Function, Pages 157-161, Carol J. Raport, Patrick W. Gray
Chapter 25 - The β2 Adrenergic Receptor as a Model for G-Protein-Coupled Receptor Structure and Activation by Diffusible Hormones, Pages 163-169, Daniel M. Rosenbaum, Søren G.F. Rasmussen, Brian K. Kobilka
Chapter 26 - Protease-Activated Receptors, Pages 171-175, Shaun R. Coughlin
Chapter 27 - Agonist-Induced Desensitization and Endocytosis of G-protein-Coupled Receptors, Pages 177-183, Michael Tanowitz, Mark von Zastrow
Chapter 28 - Functional Role(s) of Dimeric Complexes Formed from G-Protein-Coupled Receptors, Pages 185-194, Raphael Rozenfeld, Lakshmi A Devi
Chapter 29 - Chemotaxis Receptor in Bacteria: Transmembrane Signaling, Sensitivity, Adaptation, and Receptor Clustering, Pages 195-200, Weiru Wang, Sung-Hou Kim
Chapter 30 - An Overview of Ion Channel Structure, Pages 201-207, Daniel L. Minor
Chapter 31 - Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai, Pages 209-216, Aubin Penna, Shenyuan L. Zhang, Andy V. Yeromin, Michael D. Cahalan
Chapter 32 - Ion Permeation: Mechanisms of Ion Selectivity and Block, Pages 217-220, Bertil Hille
Chapter 33 - Nicotinic Acetylcholine Receptors, Pages 221-224, Arthur Karlin
Chapter 34 - Ion Channels Regulated by Direct Binding of Cyclic Nucleotides, Pages 225-231, Edgar C. Young
Chapter 35 - Overview of Cytokine Receptors, Pages 235-236, Robert M. Stroud
Chapter 36 - Growth Hormone and Prolactin Family of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation, Pages 237-243, Anthony A. Kossiakoff, Charles V. Clevenger
Chapter 37 - Erythropoietin Receptor as a Paradigm for Cytokine Signaling, Pages 245-252, Deborah J. Stauber, Minmin Yu, Ian A. Wilson
Chapter 38 - The Fibroblast Growth Factor (FGF) Signaling Complex, Pages 253-259, Wallace L. McKeehan, Fen Wang, Yongde Luo
Chapter 39 - Structure of IFNγ and its Receptors, Pages 261-263, Mark R. Walter
Chapter 40 - Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface, Pages 265-275, Hao Wu, Sarah G. Hymowitz
Chapter 41 - The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes, Pages 277-285, J. Fernando Bazan, Christian Wiesmann
Chapter 42 - The Mechanism of VEGFR Activation by VEGF, Pages 287-292, Christian Wiesmann
Chapter 43 - Receptor–Ligand Recognition in the TGFβ Superfamily as Suggested by Crystal Structures of their Ectodomain Complexes, Pages 293-300, Matthias K. Dreyer
Chapter 44 - Insulin Receptor Complex and Signaling by Insulin, Pages 301-306, Lindsay G. Sparrow, S. Lance Macaulay
Chapter 45 - Structure and Mechanism of the Insulin Receptor Tyrosine Kinase, Pages 307-313, Stevan R. Hubbard
Chapter 46 - IL-21 Increased Potency Design, Pages 315-322, Kent Bondensgaard, Lishan Kang, Siv A. Hjorth
Chapter 47 - Signaling of IL-4R, a Typical Class I Cytokine Receptor: What Defines the Quiescent State?, Pages 323-328, Thomas Weidemann, Siegfried Höfinger, Manfred Auer
Chapter 48 - Epidermal Growth Factor Kinases and their Activation in Receptor Mediated Signaling, Pages 329-336, Andrew H.A. Clayton
Chapter 49 - Tumor Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction, Pages 339-345, Qian Yin, Su-Chang Lin, Yu-Chih Lo, Steven M. Damo, Hao Wu
Chapter 50 - Assembly of Signaling Complexes for TNF Receptor Family Molecules, Pages 347-351, Gail A. Bishop, Bruce S. Hostager
Chapter 51 - Mechanisms of CD40 Signaling in the Immune System, Pages 353-358, Raul Elgueta, Victor C. de Vries, Randolph J. Noelle
Chapter 52 - Role of Lipid Domains in EGF Receptor Signaling, Pages 359-364, Linda J. Pike
Chapter 53 - Lipid-Mediated Localization of Signaling Proteins, Pages 365-371, Maurine E. Linder
Chapter 54 - Organization of Photoreceptor Signaling Complexes, Pages 373-377, Susan Tsunoda
Chapter 55 - Transmembrane Receptor Oligomerization, Pages 379-384, Darren R. Tyson, Ralph A. Bradshaw
Part II. Transmission: Effectors and Cytosolic Events, Pages 385-389, Tony Hunter
Chapter 56 - Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases, Pages 393-397, Gerard Manning, Tony Hunter
Chapter 57 - Modular Protein Interaction Domains in Cellular Communication, Pages 399-411, Tony Pawson, Piers Nash
Chapter 58 - Structures of Serine/Threonine and Tyrosine Kinases, Pages 413-417, Stevan R. Hubbard
Chapter 59 - Protein Tyrosine Kinase Receptor Signaling Overview, Pages 419-426, Carl-Henrik Heldin
Chapter 60 - Signaling by the Platelet-Derived Growth Factor Receptor Family, Pages 427-434, Lars Rönnstrand
Chapter 61 - The Epidermal Growth Factor Receptor Family, Pages 435-441, Wolfgang J. Köstler, Yosef Yarden
Chapter 62 - Mechanisms and Functions of Eph Receptor Signaling, Pages 443-449, Martin Lackmann
Chapter 63 - Cytokine Receptor Signaling, Pages 451-466, Mojib Javadi Javed, Terri D. Richmond, Dwayne L. Barber
Chapter 64 - The Negative Regulation of JAK/STAT Signaling, Pages 467-480, James M. Murphy, Gillian M. Tannahill, Douglas J. Hilton, Christopher J. Greenhalgh
Chapter 65 - Protein Kinase Inhibitors, Pages 481-490, Alexander Levitzki
Chapter 66 - Integrin Signaling: Cell Migration, Proliferation, and Survival, Pages 491-499, J. Thomas Parsons, Jill K. Slack-Davis, Robert W. Tilghman, Marcin Iwanicki, Karen H. Martin
Chapter 67 - Downstream Signaling Pathways: Modular Interactions, Pages 501-506, Bruce J. Mayer
Chapter 68 - Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function, Pages 507-516, Susan E. Levin, Arthur Weiss
Chapter 69 - Receptor Tyrosine Kinase Signaling and Ubiquitination, Pages 517-520, Daniela Hoeller, Ivan Dikic
Chapter 70 - TGFβ Signal Transduction, Pages 521-532, Cristoforo Silvestri, Rohit Bose, Liliana Attisano, Jeffrey L. Wrana
Chapter 71 - Mitogen-Activated Protein Kinases, Pages 533-538, Eric Ho, Jim Woodgett
Chapter 72 - Recognition of Phospho-Serine/Threonine Phosphorylated Proteins by Phospho-Serine/Threonine-Binding Domains, Pages 539-550, Stephen J. Smerdon, Michael B. Yaffe
Chapter 73 - AMP-Activated Protein Kinase, Pages 551-557, D. Grahame Hardie
Chapter 74 - Principles of Kinase Regulation, Pages 559-563, Bostjan Kobe, Bruce E. Kemp
Chapter 75 - Calcium/Calmodulin-Dependent Protein Kinase II, Pages 565-568, Mary B. Kennedy
Chapter 76 - Glycogen Synthase Kinase 3, Pages 569-573, Philip Cohen, Sheelagh Frame
Chapter 77 - The PIKK Family of Protein Kinases, Pages 575-580, Graeme C.M. Smith, Stephen P. Jackson
Chapter 78 - Histidine Kinases in Two-Component Signaling Pathways, Pages 581-586, Alla O. Kaserer, Ann H. West
Chapter 79 - The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases, Pages 587-599, Shari L. Wiseman, Fan-Yan Wei, Angus C. Nairn
Chapter 80 - The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana – a Paradigm for Plant LRR Receptors, Pages 601-608, John C. Walker, Kevin A. Lease
Chapter 81 - Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors, Pages 609-613, Chao Zhang, Kevan M. Shokat
Chapter 82 - Clinical Applications of Kinase Inhibitors in Solid Tumors, Pages 615-631, William Pao, Nicolas Girard
Chapter 83 - Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling, Pages 633-644, Ming Xu, Zhijian J. Chen
Chapter 84 - Global Analysis of Phosphoregulatory Networks, Pages 645-655, Janine Mok, Michael Snyder
Chapter 85 - Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins, Pages 659-675, Patricia T.W. Cohen
Chapter 86 - The Structure and Topology of Protein Serine/Threonine Phosphatases, Pages 677-681, David Barford
Chapter 87 - Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases, Pages 683-687, Carol MacKintosh, Julie Diplexcito
Chapter 88 - Protein Phosphatase 1 Binding Proteins, Pages 689-697, Anna A. DePaoli-Roach
Chapter 89 - Protein Serine/Threonine Phosphatase Inhibitors and Human Disease, Pages 699-704, Shirish Shenolikar, Matthew H. Brush
Chapter 90 - Calcineurin, Pages 705-710, Claude B. Klee, Seun-Ah Yang
Chapter 91 - Protein Serine/Threonine-Phosphatase 2C (PP2C), Pages 711-716, Hisashi Tatebe, Kazuhiro Shiozaki
Chapter 92 - Approaches to the Identification of Protein Tyrosine Phosphatase Substrates, Pages 717-725, Anton M. Bennett, Tony Tiganis
Chapter 93 - Inhibitors of Protein Tyrosine Phosphatases, Pages 727-735, Zhong-Yin Zhang
Chapter 94 - Regulating Receptor PTP Activity, Pages 737-742, Aurnab Ghose, David Van Vactor
Chapter 95 - CD45, Pages 743-748, Michelle L. Hermiston, Vikas Gupta, Arthur Weiss
Chapter 96 - Cell-Cycle Functions and Regulation of Cdc14 Phosphatases, Pages 749-753, Harry Charbonneau
Chapter 97 - MAP Kinase Phosphatases, Pages 755-769, Stephen M. Keyse
Chapter 98 - SH2 Domain-Containing Protein-Tyrosine Phosphatases, Pages 771-809, Benjamin G. Neel, Gordon Chan, Salim Dhanji
Chapter 99 - Insulin Receptor PTP: PTP1B, Pages 811-815, Sofi G. Julien, Michel L. Tremblay
Chapter 100 - STYX/Dead-Phosphatases, Pages 817-826, Matthew J. Wishart
Chapter 101 - Zebrafish and Phosphatase Function, Pages 827-833, Jeroen den Hertog, Mark van Eekelen
Chapter 102 - Eyes Absent Protein Tyrosine Phosphatases: A New Eukaryotic Branch of the Haloacid Dehalogenase Superfamily, Pages 835-842, Carolyn N. Wrobel, Ilaria Rebay
Chapter 103 - PHLPP: PH Domain Leucine-Rich Repeat Protein Phosphatase, Pages 843-848, Alexandra C. Newton
Chapter 104 - PTEN, Pages 849-854, Lloyd C. Trotman
Chapter 105 - PTP Oxidation, Pages 855-862, Ming-Fo Hsu, Yi-Wei Lou, Yi-Yun Chen, Tzu-Ching Meng
Chapter 106 - Chronophin and Slingshot Cofilin Phosphatases in Cytoskeletal Regulation, Pages 863-870, Céline DerMardirossian, Timothy Y. Huang, Gary M. Bokoch
Chapter 107 - Large-Scale Structural Analysis of Protein Tyrosine Phosphatases, Pages 871-876, Alastair J. Barr, Stefan Knapp
Chapter 108 - Protein Phosphatases and Circadian Clocks, Pages 877-881, Yanshan Fang, Amita Sehgal
Chapter 109 - Calcium Signalling; Messengers, Transport Pathways, Sensors, and Physiological Outcomes, Pages 885-886, Martin D. Bootman, H. Llewelyn Roderick
Chapter 110 - Phospholipase C, Pages 887-891, Hong-Jun Liao, Graham Carpenter
Chapter 111 - Cyclic ADP-ribose and NAADP, Pages 893-896, Antony Galione, Grant C. Churchill
Chapter 112 - Voltage-Gated Calcium Channels, Pages 897-909, William A. Catterall
Chapter 113 - Store-Operated Calcium Channels, Pages 911-914, James W. Putney Jr.
Chapter 114 - Arachidonic Acid-Regulated Ca2+ Channel, Pages 915-920, Trevor J. Shuttleworth
Chapter 115 - IP3 Receptors, Pages 921-925, Colin W. Taylor, Zhao Ding
Chapter 116 - Ryanodine Receptors, Pages 927-935, David H. MacLennan, S. R. Wayne Chen
Chapter 117 - Intracellular Calcium Signaling, Pages 937-942, Dagmar Harzheim, H. Llewelyn Roderick, Martin D. Bootman
Chapter 118 - Calcium Pumps, Pages 943-947, Ernesto Carafoli, Laura Fedrizzi, Teuta Domi, Francesca Di Leva, Marisa Brini
Chapter 119 - Sodium/Calcium Exchange, Pages 949-953, Mordecai P. Blaustein
Chapter 120 - Ca2+ Buffers, Pages 955-962, Beat Schwaller
Chapter 121 - Mitochondria as organizers of the cellular Ca2+ Signaling Network, Pages 963-972, György Szabadkai, Michael R. Duchen
Chapter 122 - EF-Hand Proteins and Calcium Sensing: The Neuronal Calcium Sensor Proteins, Pages 973-978, Lee P. Haynes, Robert D. Burgoyne
Chapter 123 - Calmodulin-Mediated Signaling, Pages 979-981, Anthony R. Means
Chapter 124 - The Family of S100 Cell Signaling Proteins, Pages 983-993, Claus W. Heizmann, Günter Fritz
Chapter 125 - Annexins and Calcium Signaling, Pages 995-998, Stephen E. Moss
Chapter 126 - Calpain, Pages 999-1008, Alan Wells, Ludovic Leloup
Chapter 127 - Calcium Signaling in Smooth Muscle, Pages 1009-1025, Susan Wray
Chapter 128 - Calcium Signaling in Cardiac Muscle, Pages 1027-1030, K.M. Dibb, A.W. Trafford, D.A. Eisner
Chapter 129 - Historical Overview: Protein Kinase C, Phorbol Ester and Lipid Mediators, Pages 1033-1035, Yasutomi Nishizuka, Ushio Kikkawa
Chapter 130 - Type I Phosphatidylinositol 4-Phosphate 5-Kinases (PI4P 5-kinases), Pages 1037-1041, K.A. Hinchliffe, R.F. Irvine
Chapter 131 - Type II PIP4-kinases, Pages 1043-1048, Lucia Rameh
Chapter 132 - Phosphoinositide 3-Kinases, Pages 1049-1060, David A. Fruman
Chapter 133 - PTEN/MTM Phosphatidylinositol Phosphatases, Pages 1061-1064, Knut Martin Torgersen, Soo-A Kim, Jack E. Dixon
Chapter 134 - The Src Homology 2 Containing Inositol 5′ Phosphatases, Pages 1065-1083, Frann Antignano, Jens Ruschmann, Melisa Hamilton, Victor Ho, Vivian Lam, Etsushi Kuroda, Laura M. Sly, Gerald Krystal
Chapter 135 - Structural Principles of Lipid Second Messenger Recognition, Pages 1085-1092, Roger L. Williams
Chapter 136 - Pleckstrin Homology (PH) Domains, Pages 1093-1101, Mark A. Lemmon
Chapter 137 - PX Domains, Pages 1103-1109, Christian D. Ellson, Michael B. Yaffe
Chapter 138 - FYVE Domains in Membrane Trafficking and Cell Signaling, Pages 1111-1121, Christopher Stefan, Anjon Audhya, Scott D. Emr
Chapter 139 - Protein Kinase C: Relaying Signals from Lipid Hydrolysis to Protein Phosphorylation, Pages 1123-1129, Alexandra C. Newton
Chapter 140 - Modulation of Monomeric G Proteins by Phosphoinositides, Pages 1131-1139, Sonja Vermeren, Len Stephens, Phillip T. Hawkins
Chapter 141 - Phosphoinositides and Actin Cytoskeletal Rearrangement, Pages 1141-1150, Paul A. Janmey, Robert Bucki, Helen L. Yin
Chapter 142 - Phosphatidylinositol Transfer Proteins, Pages 1151-1158, Shamshad Cockcroft
Chapter 143 - Inositol Pentakisphosphate: A Signal Transduction Hub, Pages 1159-1165, Stephen B. Shears
Chapter 144 - Phospholipase D, Pages 1167-1176, Wenjuan Su, Michael A. Frohman
Chapter 145 - Diacylglycerol Kinases, Pages 1177-1182, Matthew K. Topham, Steve M. Prescott
Chapter 146 - Sphingosine-1-Phosphate Receptors: An Update, Pages 1183-1189, Michael Maceyka, Sarah Spiegel
Chapter 147 - Lysophosphatidic Acid and Sphingosine-1-Phosphate Activation of G-Protein-Coupled Receptors, Pages 1191-1200, Tetsuji Mutoh, Jerold Chun
Chapter 148 - The Role of Ceramide in Cell Regulation, Pages 1201-1211, Leah J. Siskind, Thomas D. Mullen, Lina M. Obeid
Chapter 149 - Role of Phospholipase A2 Forms in Arachidonic Acid Mobilization and Eicosanoid Generation, Pages 1213-1217, Jesús Balsinde, Edward A. Dennis
Chapter 150 - Prostaglandin Mediators, Pages 1219-1228, Emer M. Smyth, Garret A. FitzGerald
Chapter 151 - Leukotriene Mediators, Pages 1229-1234, Jesper Z. Haeggström, Anders Wetterholm
Chapter 152 - Lipoxins and Aspirin-Triggered 15-epi-Lipoxins: Pro-Resolving Mediators in Anti-Inflammation and Resolution, Pages 1235-1242, Charles N. Serhan
Chapter 153 - Protein Proximity Interactions, Page 1245, Matthew G. Gold, John D. Scott
Chapter 154 - Rapid Characterization of in vivo Phosphorylation Sites and the Protein Kinases and Phosphatases that Regulate them by Affinity Capture, Pages 1247-1251, Timothy A.J. Haystead
Chapter 155 - FRET Analysis of Signaling Events in Cells, Pages 1253-1257, Peter J. Verveer, Philippe I.H. Bastiaens
Chapter 156 - The Focal Adhesion: A Network of Molecular Interactions, Pages 1259-1264, Jianxin A. Yu, Nicholas O. Deakin, Christopher E. Turner
Chapter 157 - WASP and WAVE Family Protein Complexes, Pages 1265-1270, Frank M. Mason, Scott H. Soderling
Chapter 158 - Synaptic NMDA-Receptor Signaling Complex, Pages 1271-1275, Mary B. Kennedy
Chapter 159 - Toll Family Receptors, Pages 1277-1281, Yann Hyvert, Jean-Luc Imler
Chapter 160 - Signaling and the Immunological Synapse, Pages 1283-1291, Emanuele Giurisato, Andrey S. Shaw
Chapter 161 - The Ubiquitin–Proteasome System, Pages 1293-1296, Mark Hochstrasser
Chapter 162 - Caspases: Cell Signaling by Proteolysis, Pages 1297-1302, Guy S. Salvesen
Chapter 163 - MAP Kinase in Yeast, Pages 1303-1314, Rupam Sahoo, Amjad Husain, Elaine A. Elion
Chapter 164 - Mammalian MAP Kinases, Pages 1315-1328, Norman J. Kennedy, Roger J. Davis
Chapter 165 - Subcellular Targeting of PKA through AKAPs: Conserved Anchoring and Unique Targeting Domains, Pages 1329-1336, Matthew D. Pink, Mark L. Dell’Acqua
Chapter 166 - AKAP Transduction Units: Context Dependent Assembly of Signaling Complexes, Pages 1337-1342, John D. Scott, Lorene K. Langeberg
Chapter 167 - Dendritic Protein Phosphatase Complexes, Pages 1343-1352, Anthony J. Baucum II, Roger J. Colbran
Chapter 168 - Protein Phosphatase 2A, Pages 1353-1365, Adam M. Silverstein, Anthony J. Davis, Vincent A. Bielinski, Edward D. Esplin, Nadir A. Mahmood, Marc C. Mumby
Chapter 169 - 14-3-3 Proteins, Pages 1367-1374, Hubert Hondermarck
Chapter 170 - Protein Interaction Data Resources, Pages 1375-1385, Ian M. Donaldson
Chapter 171 - Adenylyl Cyclases, Pages 1389-1397, Adam J. Kuszak, Roger K. Sunahara
Chapter 172 - Guanylyl Cyclases, Pages 1399-1407, Lincoln R. Potter
Chapter 173 - Phosphodiesterase Families, Pages 1409-1414, James Surapisitchat, Joseph A. Beavo
Chapter 174 - The cAMP-Specific Phosphodiesterases: A Class of Diverse Enzymes that Define the Properties and Localization of cAMP Signals, Pages 1415-1423, James L. Weeks II, Marco Conti
Chapter 175 - cAMP/cGMP Dual-Specificity Phosphodiesterases, Pages 1425-1437, Lena Stenson, Eva Degerman, Vincent C. Manganiello
Chapter 176 - Phosphodiesterase-5, Pages 1439-1444, Sharron H. Francis, Jackie D. Corbin
Chapter 177 - Function and Regulation of Photoreceptor Phosphodiesterase (PDE6) in the Visual Signaling Pathway, Pages 1445-1451, Rick H. Cote, Karyn B. Cahill
Chapter 178 - Regulation of Cyclic Nucleotide Levels by Sequestration, Pages 1453-1459, Jackie D. Corbin, Jun Kotera, Venkatesh K. Gopal, Gary Z. Morris, Rick H. Cote, Sharron H. Francis
Chapter 179 - cAMP-Dependent Protein Kinase, Pages 1461-1469, Susan S. Taylor, Elzbieta Radzio-Andzelm
Chapter 180 - Cyclic GMP-Dependent Protein Kinase: Targeting and Control of Expression, Pages 1471-1477, Thomas M. Lincoln, Hassan Sellak, Nupur Dey, Chung-Sik Choi, Felricia Brown
Chapter 181 - Inhibitors of Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases, Pages 1479-1487, Wolfgang R. Dostmann, Christian K. Nickl
Chapter 182 - Substrates of Cyclic Nucleotide-Dependent Protein Kinases, Pages 1489-1495, Neil F. W. Saunders, Ross I. Brinkworth, Bruce E. Kemp, Bostjan Kobe
Chapter 183 - Physiological Substrates of PKA and PKG, Pages 1497-1514, Anja Ruppelt, Nikolaus G. Oberprieler, George Magklaras, Kjetil Taskén
Chapter 184 - Effects of cGMP-Dependent Protein Kinase Knockouts, Pages 1515-1518, Franz Hofmann, Thomas Kleppisch
Chapter 185 - Cyclic Nucleotide-Regulated Cation Channels, Pages 1519-1523, Martin Biel
Chapter 186 - Epac, cAMP-Regulated Guanine Nucleotide Exchange Factors for Rap1 and Rap2, Pages 1525-1529, Holger Rehmann, Johan de Rooij, Johannes L. Bos
Chapter 187 - Cyclic Nucleotide-Binding GAF Domains in Phosphodiesterases and Adenylyl Cyclases, Pages 1531-1536, Sergio E. Martinez, Clemens C. Heikaus, Joseph A. Beavo
Chapter 188 - Use of Chimeric Adenylyl Cyclases to Study Cyclic Nucleotide Signaling, Pages 1537-1542, Jürgen U. Linder, Joachim E. Schultz
Chapter 189 - Cyclic Nucleotide Signaling in the Kinetoplastids, Pages 1543-1547, Stefan Kunz, Mihaela Minca, Edith Luginbühl, Patrick Bregy, Thomas Seebeck
Chapter 190 - Cyclic Nucleotide Specificity and Cross-Activation of Cyclic Nucleotide Receptors, Pages 1549-1554, John B. Shabb
Chapter 191 - Cyclic Nucleotide Analogs as Tools to Investigate Cyclic Nucleotide Signaling, Pages 1555-1562, Anne Elisabeth Christensen, Kristin Viste, Stein Ove Døskeland
Chapter 192 - cGMP and PKG Signaling in Platelets, Pages 1563-1567, Stepan Gambaryan, Ulrich Walter
Chapter 193 - Use of siRNA and Antisense Knockdown to Study Regulation of PKA by PKI, Pages 1569-1572, Edward M. Greenfield, Xin Chen
Chapter 194 - Cyclic Nucleotide Signaling in the Central Nervous System, Pages 1573-1579, Diego A. Golombek, Patricia V. Agostino
Chapter 195 - Compartmentation of cAMP in Cardiomyocytes, Pages 1581-1587, Grégoire Vandecasteele, Rodolphe Fischmeister
Chapter 196 - Phosphodiesterase-9A: A cGMP-Specific Enzyme, Pages 1589-1593, Jun Kotera, Takashi, Sasaki, Kenji Omori
Chapter 197 - Signal Transduction by G Proteins: Basic Principles, Molecular Diversity, and Structural Basis of Their Actions, Pages 1597-1614, Lutz Birnbaumer
Chapter 198 - Heterotrimeric G-Protein Signaling at Atomic Resolution, Pages 1615-1619, David G. Lambright
Chapter 199 - In vivo Functions of Heterotrimeric G Proteins, Pages 1621-1627, Stefan Offermanns
Chapter 200 - Regulation of G Proteins by Covalent Modification, Pages 1629-1633, Benjamin C. Jennings, Maurine E. Linder
Chapter 201 - G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation, Pages 1635-1648, Todd R. Palmby, Hans Rosenfeldt, J. Silvio Gutkind
Chapter 202 - Signaling Through Gz, Pages 1649-1653, Michelle E. Kimple, Rainbo C. Hultman, Patrick J. Casey
Chapter 203 - Effectors of Gαo, Pages 1655-1663, Yana Zorina, Ravi Iyengar, Kenneth D. Bromberg
Chapter 204 - Mono-ADP-Ribosylation of Heterotrimeric G Proteins, Pages 1665-1672, Maria Di Girolamo, Daniela Corda
Chapter 205 - Specificity of G-Protein βγ Dimer Signaling, Pages 1673-1682, Carl A. Hansen, William F. Schwindinger, Janet D. Robishaw
Chapter 206 - The Superfamily of “Regulator of G-Protein Signaling” (RGS) Proteins, Pages 1683-1703, Melinda D. Willard, Francis S. Willard, David P. Siderovski
Chapter 207 - G-Protein Signaling in Chemotaxis, Pages 1705-1712, Jonathan Franca-Koh, Stacey Sedore Willard, Peter N. Devreotes
Chapter 208 - Reversible Palmitoylation in G Protein Signaling, Pages 1713-1720, Philip B. Wedegaertner
Chapter 209 - G Proteins in Gustatory Transduction, Pages 1721-1726, Bedrich Mosinger, Sami Damak, Robert F. Margolskee
Chapter 210 - Regulation of Synaptic Fusion by Heterotrimeric G Proteins, Pages 1727-1734, Simon Alford, Edaeni Hamid, Trillium Blackmer, Tatyana Gerachshenko
Chapter 211 - G-Protein Regulation of Channels, Pages 1735-1739, Ofer Wiser, Lily Yeh Jan
Chapter 212 - Ras and Cancer, Pages 1741-1743, Frank McCormick
Chapter 213 - The Influence of Intracellular Location on Function of Ras Proteins, Pages 1745-1752, Jodi McKay, Janice E. Buss
Chapter 214 - Role of R-Ras in Cell Growth, Pages 1753-1762, Gretchen A. Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin, Channing J. Der
Chapter 215 - The Ran GTPase: Cellular Roles and Regulation, Pages 1763-1771, Mary Dasso
Chapter 216 - Regulation of NADPH Oxidases by Rac GTPase, Pages 1773-1780, Gary M. Bokoch, Davide Gianni, Jun-Sub Kim, Yu-Ya Kao
Chapter 217 - The Role of Rac and Rho in Cell Cycle Progression, Pages 1781-1784, Laura J. Taylor, Dafna Bar-Sagi
Chapter 218 - Cdc42 and Its Cellular Functions, Pages 1785-1794, Qiyu Feng, Richard A. Cerione
Chapter 219 - Tissue Transglutaminase: A Unique GTP-Binding/GTPase, Pages 1795-1802, Marc Antonyak, Richard A. Cerione
Chapter 220 - Roles for ADP-Ribosylation Factors in Membrane Traffic, Pages 1803-1812, Amanda Caster, Richard A. Kahn
Chapter 221 - Yeast Small G-Protein Function: Molecular Basis of Cell Polarity in Yeast, Pages 1813-1817, Keith G. Kozminski, Hay-Oak Park
Chapter 222 - Farnesyltransferase Inhibitors, Pages 1819-1826, James J. Fiordalisi, Adrienne D. Cox
Chapter 223 - Structure of Rho Family Targets, Pages 1827-1842, Helen R. Mott, Darerca Owen
Chapter 224 - Structural Features of RhoGEFs, Pages 1843-1847, Jason T. Snyder, Kent L. Rossman, David K. Worthylake, John Sondek
Chapter 225 - Structural Considerations of Small GTP-Binding Proteins, Pages 1849-1853, Alfred Wittinghofer
Chapter 226 - Mx Proteins: High Molecular Weight GTPases with Antiviral Activity, Pages 1855-1864, Georg Kochs, Otto Haller
Chapter 227 - Interactions Between Wnt/β-Catenin/Fgf and Chemokine Signaling in Lateral Line Morphogenesis, Pages 1867-1872, Tatjana Piotrowski
Chapter 228 - Wnt S