Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Front Matter....Pages i-xv
Molecular Targets....Pages 1-27
Preclinical Screening for New Anticancer Agents....Pages 29-44
Mouse Models in Cancer Drug Discovery and Development....Pages 45-55
Defining the Starting Dose....Pages 57-73
Phase I Trials in Oncology....Pages 75-80
Analytical Methods....Pages 81-90
Validation and Control of Bioanalytical Methods in Clinical Drug Development....Pages 91-110
Clinical Pharmacology Overview....Pages 111-127
Pharmacokinetic Modeling....Pages 129-137
Pharmacodynamic Modeling....Pages 139-148
Pharmacometric Knowledge-Based Oncology Drug Development....Pages 149-167
Protein Binding of Anticancer Drugs....Pages 169-188
Metabolism (Non-CYP Enzymes)....Pages 189-213
Cytochrome P450 and Anticancer Drugs....Pages 215-229
Polymorphisms in Genes of Drug Targets and Metabolism and in DNA Repair....Pages 231-243
Drug Interactions....Pages 245-266
ABC Transporters....Pages 267-288
Intrathecal Chemotherapy....Pages 289-306
Use of Microdialysis in Preclinical and Clinical Development of Anticancer Agents....Pages 307-326
Regional Therapy of Cancer Using Continuous Hyperthermic Peritoneal Perfusion or Vascular Isolation and Perfusion Techniques....Pages 327-348
Isolated Lung Perfusion for the Treatment of Inoperable Pulmonary Malignancies....Pages 349-362
Pharmacokinetics of Isolated Lung Perfusion with Antitumor Agents....Pages 363-371
Central Nervous System Malignancy and Clinical Pharmacology....Pages 373-393
Pharmacokinetics of Anticancer Drugs in Children....Pages 395-419
Clinical Pharmacokinetics in the Elderly....Pages 421-430
The Combination of Angiogenesis Inhibitors and Radiotherapy for the Treatment of Primary Tumors....Pages 431-438
Gene Therapy for the Treatment of Cancer....Pages 439-456
Vaccines for the Treatment of Cancer....Pages 457-473
Pharmacokinetics of Antibodies and Immunotoxins in Mice and Humans....Pages 475-498
Pharmacokinetics of Biologicals....Pages 499-522
Exposure-Response Relationship of Anticancer Agents....Pages 523-537
Identifying Agents to Test in Phase III Trials....Pages 539-578
Clinical Trial Designs for Approval of New Anticancer Agents....Pages 579-592
Pharmacogenetic Counseling....Pages 593-611
Back Matter....Pages 613-623