Guanidino Compounds in Biology and Medicine

Front Matter....Pages i-1
Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes....Pages 3-9
Inhibition of arginine synthesis by urea: A mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation....Pages 11-15
Smooth muscle and NMR review: An overview of smooth muscle metabolism....Pages 17-30
Methyl group deficiency and guanidino production in Uremia....Pages 31-36
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells....Pages 37-43
The clinical syndrome of creatine transporter deficiency....Pages 45-48
Creatine supplementation in health and disease: What is the evidence for long-term efficacy?....Pages 49-55
A role for guanidino compounds in the brain....Pages 57-62
Electron paramagnetic resonance imaging of nitric oxide organ distribution in lipopolysuccaride treated mice....Pages 63-67
Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: Changing patterns in development and with increased activity....Pages 69-76
Monocarboxylates and glucose utilization as energy substrates in rat brain slices under selective glial poisoning-a 31 P NMR study....Pages 77-81
Creatine supplementation during college football training does not increase the incidence of cramping or injury....Pages 83-88
Effects of creatine supplementation on performance and training adaptations....Pages 89-94
Long-term creatine supplementation does not significantly affect clinical markers of health in athletes....Pages 95-104
Creatine supplementation enhances anaerobic ATP synthesis during a single 10 sec maximal handgrip exercise....Pages 105-112
Association of ecNOS gene polymorphisms with end stage renal diseases....Pages 113-118
Importance of renal mitochondria in the reduction of TEMPOL, a nitroxide radical....Pages 119-124
Effect of caffeine on metabolism of L-arginine in the brain....Pages 125-128
Role of nitric oxide synthase activity in experimental ischemic acute renal failure in rats....Pages 129-133
Alteration of energy production by the heart in CRF patients undergoing peritoneal dialysis....Pages 135-138
Oral L -arginine can reverse digital necrosis in Raynaud’s phenomenon....Pages 139-141
Creatine deficiency syndromes....Pages 143-150
Human skeletal muscle creatine transporter mRNA and protein expression in healthy, young males and females....Pages 151-157
Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans....Pages 159-166
Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis....Pages 167-176
Arginine deprivation and tumour cell death: Arginase and its inhibition....Pages 177-185
Back Matter....Pages 187-192