Goodman and Gilman's The Pharmacological Basis of Therapeutics

Cover
Title Page
Copyright Page
Dedication
Contents
Contributors
Preface
Acknowledgments
Section I General Principles
	1. Drug Discovery: From Medicinal Plants to Computer-Aided Drug Design
	2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination
	3. Pharmacodynamics: Molecular Mechanisms of Drug Action
	4. Membrane Transporters and Drug Response
	5. Drug Metabolism
	6. The Gastrointestinal Microbiome and Drug Response
	7. Pharmacogenetics and Pharmacogenomics
	8. Postmarketing Drug Safety
	9. Principles of Clinical Toxicology
Section II Neuropharmacology
	10. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
	11. Muscarinic Receptor Agonists and Antagonists
	12. Anticholinesterase Inhibitors and Reactivators
	13. Neuromuscular Junction and Autonomic Ganglia; Nicotine, Muscle Relaxants, and Spasmolytics
	14. Adrenergic Agonists and Antagonists
	15. 5-Hydroxytryptamine (Serotonin) and Dopamine
	16. Neurotransmission in the Central Nervous System
	17. The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain
	18. Drug Therapy of Depression and Anxiety Disorders
	19. Pharmacotherapy of Psychosis and Mania
	20. Pharmacotherapy of the Epilepsies
	21. Treatment of Central Nervous System Degenerative Disorders
	22. Hypnotics and Sedatives
	23. Opioid Analgesics
	24. General Anesthetics and Therapeutic Gases
	25. Local Anesthetics
	26. Cannabinoids
	27. Ethanol
	28. Drug Use Disorders and Addiction
Section III Modulation of Pulmonary, Renal, and Cardiovascular
	29. Drugs Affecting Renal Excretory Function
	30. Renin and Angiotensin
	31. Treatment of Ischemic Heart Disease
	32. Treatment of Hypertension
	33. Therapy of Heart Failure
	34. Antiarrhythmic Drugs
	35. Treatment of Pulmonary Arterial Hypertension
	36. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
	37. Drug Therapy for Dyslipidemias
Section IV Inflammation, Immunomodulation, and Hematopoiesis
	38. Introduction to Immunity and Inflammation
	39. Immunosuppressants, Immunomodulation, and Tolerance
	40. Immune Globulins and Vaccines
	41. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
	42. Pharmacotherapy of Inflammation, Fever, Pain, and Gout
	43. Histamine, Bradykinin, and Their Antagonists
	44. Pulmonary Pharmacology
	45. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Section V Endocrine Pharmacology
	46. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis
	47. Thyroid and Antithyroid Drugs
	48. Estrogens, Progestins, and the Female Reproductive Tract
	49. Androgens and the Male Reproductive Tract
	50. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex
	51. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia
	52. Agents Affecting Mineral Ion Homeostasis and Bone Turnover
Section VI Gastrointestinal Pharmacology
	53. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
	54. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease
	55. Pharmacotherapy of Inflammatory Bowel Disease
Section VII Chemotherapy of Infectious Diseases
	56. General Principles of Antimicrobial Therapy
	57. DNA Disruptors: Sulfonamides, Quinolones, and Nitroimidazoles
	58. Cell Envelope Disruptors: β-Lactam, Glycopeptide, and Lipopeptide Antibacterials
	59. Miscellaneous Antibacterials: Aminoglycosides, Polymyxins, Urinary Antiseptics, Bacteriophages
	60. Protein Synthesis Inhibitors
	61. Antifungal Agents
	62. Antiviral Agents (Nonretroviral)
	63. Treatment of Viral Hepatitis (HBV/HCV)
	64. Antiretroviral Agents and Treatment of HIV Infection
	65. Chemotherapy of Tuberculosis and Nontuberculous Mycobacteria, Including Leprosy
	66. Chemotherapy of Malaria
	67. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
	68. Chemotherapy of Helminth Infections
Section VIII Pharmacotherapy of Neoplastic Disease
	69. General Principles in the Pharmacotherapy of Cancer
	70. Cytotoxics and Antimetabolites
	71. Protein Kinase Inhibitors and Pathway-Targeted Small Molecules
	72. Antibodies, CAR T Cells, and Proteins to Treat Cancer
	73. Hormones, Hormone Receptor Antagonists, and Related Agents in the Therapy of Cancer
Section IX Special Systems Pharmacology
	74. Ocular Pharmacology
	75. Dermatological Pharmacology
	76. Environmental Toxicology
Appendices
	I. Design and Optimization of Dosage Regimens: Pharmacokinetic Data
	II. Drug-Drug Interactions
Index