Glycobiology of the Nervous System

Front Matter....Pages i-xvii
Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates....Pages 1-31
Introduction to Cells Comprising the Nervous System....Pages 33-45
Synthesis, Processing, and Function of N-glycans in N-glycoproteins....Pages 47-70
Synthesis of O-Linked Glycoconjugates in the Nervous System....Pages 71-87
Chemistry and Function of Glycosaminoglycans in the Nervous System....Pages 89-115
Use of Glycan-Targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System....Pages 117-127
From Mass Spectrometry-Based Glycosylation Analysis to Glycomics and Glycoproteomics....Pages 129-164
Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR....Pages 165-183
Glycolipid and Glycoprotein Expression During Neural Development....Pages 185-222
Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System....Pages 223-244
Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System....Pages 245-262
Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a Glycosynapse....Pages 263-291
Glycosignaling: A General Review....Pages 293-306
Glycosphingolipids in the Regulation of the Nervous System....Pages 307-320
Glycobiology of Ion Transport in the Nervous System....Pages 321-342
O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration....Pages 343-366
N-Glycosylation in Regulation of the Nervous System....Pages 367-394
Roles of Carbohydrates in the Interaction of Pathogens with Neural Cells....Pages 395-413
Glycoconjugate Changes in Aging and Age-Related Diseases....Pages 415-447
Gangliosides and Glycolipids in Neurodegenerative Disorders....Pages 449-461
Glycosidases: Inborn Errors of Glycosphingolipid Catabolism....Pages 463-484
Ganglioside Storage Diseases: On the Road to Management....Pages 485-499
Dynamic Aspects of Neural Tumor Gangliosides....Pages 501-515
Galectins and Neuroinflammation....Pages 517-542
Glycoconjugates and Neuroimmunological Diseases....Pages 543-566
Back Matter....Pages 567-584