GLUCAGON: Its Role in Physiology and Clinical Medicine

Content: 
Front Matter....Pages i-xli
Front Matter....Pages n1-n1
Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production....Pages 1-22
Morphologic Study of Glucagon Release....Pages 23-30
Front Matter....Pages n2-n2
Glucagon Biosynthesis in Anglerfish Islets: Identification of A 4,900 Dalton Metabolic Conversion Intermediate....Pages 31-50
High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas....Pages 51-63
Assessment of Glucagon Immunoreactivity in Plasma....Pages 65-76
Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States....Pages 77-92
Circulating Glucagon Components: Significance in Health and Disease....Pages 93-112
Plasma Immunoreactive Glucagon in Depancreatized Animals....Pages 113-127
Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI)....Pages 129-135
Glucagon-Like Materials in Porcine and Rat Intestinal Mucosa....Pages 137-141
Immunoreactive Glucagon in the Salivary Glands of Man and Animal....Pages 143-155
Role of the Submaxillary Gland and of the Kidney in the Hyperglucagonemia of Eviscerated Rats....Pages 157-166
Glucagon and the Kidney....Pages 167-176
Front Matter....Pages n3-n3
The Role of Calcium in Glucagon Secretion....Pages 177-183
The Versatile Role of Calcium in Glucagon Release....Pages 185-213
Interrelationship of Calcium and Somatostatin in the Secretion of Insulin and Glucagon....Pages 215-230
Dynamics and Interrelationships of In Vitro Secretion of Glucagon and Insulin....Pages 231-241
Effects of Insulin on the Glucagon Release, Glucose Utilization and ATP Content of the Pancreatic A Cells of the Guinea Pig....Pages 243-254
Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas....Pages 255-269
The Role of the Autonomic Nervous System in Glucagon Secretion....Pages 271-286
Front Matter....Pages n4-n4
Interactions of Hepatocyte Membrane Receptors with Pancreatic and Gut Glucagon....Pages 287-303
Glucagon, Insulin and their Hepatic Receptors: An Endocrine Pattern Characterizing Hepatoproliferative Transitions in the Rat....Pages 305-319
Reexamination of the Second Messenger Hypothesis of Glucagon and Catecholamine Action in Liver....Pages 321-347
Guanyl Nucleotide Regulation of the Liver Glucagon-Sensitive Adenylyl Cyclase System....Pages 349-371
A Peptide Inhibitor of Glucagon-Responsive Adenylate Cyclase in Liver....Pages 373-378
Modulation of Nuclear Protein Kinase Activity by Glucagon....Pages 379-391
Combined Influence of Insulin and Glucagon Upon Hepatocytes in Rats with Liver Loss or Viral Injury....Pages 393-402
Front Matter....Pages n5-n5
Insulin and Glucagon (Pancreatic and Extrapancreatic) Interactions and the Regulation of Glucose Turnover in Physiology and in the Diabetic State....Pages 403-436
Regulation of Hepatic Gluconeogenesis by Glucagon in the Rat....Pages 437-458
Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control by Glucagon....Pages 459-485
The Role of Glucagon in Amino Acid Homeotasis....Pages 487-494
The Roles of Glucagon and Cyclic Adenosine 3′,5′-Monophosphate in the Regulation of Lipid Biosynthesis....Pages 495-516
Lowering of Plasma Lipids, The Major Effect of Repeated Glucagon Administration in Rats....Pages 517-532
Glucagon and Lipoprotein Regulation in Man....Pages 533-550
Metabolic Fuels in the Embryo and the Newborn....Pages 551-561
Role of the Insulin/Glucagon Ratio in the Changes of Hepatic Metabolism During Development of the Rat....Pages 563-581
Glucose Homeostasis in the Newborn....Pages 583-593
Front Matter....Pages n6-n6
New Concepts in Glucagon Physiology....Pages 595-605
The Issues Related to Abnormal A Cell Function in Diabetes Mellitus....Pages 607-615
On the Causes and Consequences of Abnormal Glucagon Secretion in Human Diabetes Mellitus....Pages 617-641
Front Matter....Pages n6-n6
The Effects of Exogenously Induced Hyperglucagonemia in Insulin-Treated Diabetics....Pages 643-650
The Nature of the A Cell Abnormality in Human Diabetes Mellitus....Pages 651-661
The Nature of Hyperglucagonemia in Diabetes Mellitus....Pages 663-677
Glucagon in Diabetic Coma....Pages 679-689
Glucagon Metabolism in Potential Diabetes Mellitus. Studies of Discordant Twins and Patients After Myocardial Infarction....Pages 691-698
Tolbutamide: Stimulator and Suppressor of Glucagon Secretion....Pages 699-710
Effect of Long Term Sulfonylurea Therapy on Glucagon Levels in Maturity Onset Diabetes Mellitus....Pages 711-721
Effect of Chlorpropamide on Basal and Arginine-Stimulated Plasma Levels of Glucagon and Insulin in Diabetic Patients....Pages 723-733
Glucagon and Hypertriglyceridemia....Pages 735-757
Glucagonomas and Skin Disease....Pages 759-763
Plasma GLI in Gastrectomized Patients....Pages 765-776
Pancreatic A Cell Function in a Patient with Addison’s Disease....Pages 777-781
Back Matter....Pages 783-793