Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing

Front Matter....Pages i-xx
Overview of Designing Genetically Engineered Mouse (GEM) Models....Pages 1-15
The Use of Cre–loxP Technology and Inducible Systems to Generate Mouse Models of Cancer....Pages 17-36
Using Recombineering Technology to Create Genetically Engineered Mouse Models....Pages 37-56
Insertional Mutagenesis for Generating Mouse Models of Cancer....Pages 57-82
The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer....Pages 83-111
Target-Selected ENU Mutagenesis to Develop Cancer Models in the Rat....Pages 113-131
The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology....Pages 133-180
Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer....Pages 181-191
Characterization of Chromosomal Translocations in Mouse Models of Hematological Malignancies Using Spectral Karyotyping, FISH, and Immunocytochemistry....Pages 193-207
Expression Profiling of Mouse Models of Human Cancer: Model Categorization and Guidance for Preclinical Testing....Pages 209-234
Imaging Mouse Models of Human Cancer....Pages 235-260
Identifying Mammary Epithelial Stem and Progenitor Cells....Pages 261-279
Differentiation Programs in Development and Cancer....Pages 281-292
Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse....Pages 293-308
Mouse Models for Colorectal Cancer....Pages 309-329
Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression....Pages 331-352
Maspin and Suppression of Tumor Metastasis....Pages 353-373
Epigenetic Mouse Models....Pages 375-396
Modeling Transforming Growth Factor-ß Signaling in Cancer....Pages 397-415
Modeling Stromal–Epithelial Interactions....Pages 417-442
Utilizing Mouse Models of Human Cancer for Assessing Immune Modulation of Cancer Development....Pages 443-463
Transplanted Tumor Models for Preclinical Drug Testing and the Potential Benefit of Genetically Engineered Mouse Models....Pages 465-476
The Development and Use of Genetically Tractable Preclinical Mouse Models....Pages 477-495
Animal Models for Breast Cancer Prevention Research....Pages 497-526
Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies....Pages 527-547
Mouse Models in Preclinical Drug Development: Applications to CNS Models....Pages 549-567
Mouse Models of Human Cancer: Role in Preclinical Testing and Personalized Medicine....Pages 569-589
Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development....Pages 591-618
Back Matter....Pages 619-632