Genetic Variants in Periodontal Health and Disease

Cover......Page 1
ISBN: 978-3-642-00679-1......Page 4
Dedication......Page 5
Foreword......Page 6
Preface......Page 7
Contents......Page 8
1.1 Gingival Diseases......Page 11
1.2 Diseases of the Tooth Supporting Structures......Page 14
1.2.1 Chronic Periodontitis......Page 17
1.2.2 Aggressive Periodontitis......Page 18
1.2.4 Necrotizing Forms of Periodontitis......Page 19
1.2.5 Developmental or Acquired Deformities and Conditions......Page 20
1.3 Essentialistic or Nominalistic Disease Classification......Page 21
References......Page 23
Evidence for the Role of Genetic Variants in Periodontitis......Page 25
2.1 Study of Inherited Diseases and Genetic Syndromes......Page 26
2.2 Family Studies......Page 27
2.4 Population Studies......Page 28
References......Page 29
A Gene Mutation of Major Effect on Human Disease and Its Association with Periodontitis......Page 30
3.1 Papillon-Lefèvre Syndrome......Page 31
3.2 Haim-Munk Syndrome......Page 32
3.4 Cyclic Neutropenia......Page 33
3.7 Leukocyte Adhesion Deficiency......Page 34
3.8 Congenital Disorder of Glycosylation Type IIc CDG-IIc (Also Known as LAD II)......Page 36
References......Page 37
4.1 Interleukin-1 Gene Polymorphisms......Page 39
4.1.1 Interleukin-1 Genotype and Experimental Gingivitis......Page 40
4.1.2 Interleukin-1 Genotype and Chronic Periodontitis......Page 42
4.1.4 Interleukin-1 Genotype and Smoking......Page 46
4.1.5 Interleukin-1 Genotype and IL-1 Levels......Page 47
4.1.6 Interleukin-1 Genotype and Periodontal Treatment......Page 48
4.1.8 Interleukin-1 Genotype and Oral Implants......Page 50
4.2 Interleukin-2 Gene Polymorphisms......Page 52
4.4 Interleukin-6 Gene Polymorphisms......Page 53
4.5 Interleukin-10 Gene Polymorphisms......Page 54
4.7 Interleukin-18 Gene Polymorphisms......Page 56
Transforming Growth Factor-b (TGF-b) Gene Polymorphisms......Page 58
4.9 Fc Receptor Polymorphisms......Page 59
4.10 Tumor Necrosis Factor-a......Page 65
4.11 Human Leukocyte Antigen Polymorphisms......Page 66
4.12 CD14 Gene Polymorphisms......Page 69
4.13 Toll like receptor, TLR2 and TLR4 Gene Polymorphisms......Page 72
4.14 CARD15/NOD2 Gene Polymorphisms......Page 73
N-Formyl-l-Methionyl-l-Leucyl-l-Phenylalanine Receptor Polymorphisms......Page 76
4.16 Matrix Metalloproteinase Polymorphisms......Page 78
4.17 Cathepsin C Polymorphisms......Page 84
4.18 Vitamin D Receptor Polymorphisms......Page 85
4.20 RANK/Osteoprotegerin Gene Polymorphism......Page 89
4.21 Plasminogen Activator Gene Polymorphism......Page 92
NAT2 (N-acetyltransferase) Gene Polymorphism......Page 93
4.23 Fibrinogen Gene Polymorphism......Page 95
Estrogen Receptor-a Gene Polymorphism......Page 96
4.25 Cytochrome P450 Gene Polymorphism......Page 97
4.26 RAGE (Receptor of Advanced Glycation End-Products) Gene Polymorphism......Page 98
4.27 CCR5 (Crotonyl Coenzyme Reductase 5) Gene Polymorphism......Page 99
4.28 Lactoferrin Gene Polymorphism......Page 100
Interferon-g Gene Polymorphisms......Page 101
References......Page 103
Heritability of Chronic Periodontitis......Page 121
References......Page 124
Heritability of Aggressive Periodontitis......Page 125
References......Page 127
Heritability of Gingivitis......Page 129
References......Page 130
Heritability of Peri-Implantitis......Page 132
References......Page 133
9.1 Ethnic Heterogeneity......Page 134
9.4 Sample Size of the Study Subjects......Page 135
References......Page 136
Clinical Utility of Genetic Knowledge......Page 137
References......Page 138
Index......Page 139