Genetic Predisposition to Cancer

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Genetic predisposition to cancer: an introduction....Pages 3-15
From families to chromosomes: genetic linkage, and other methods for finding cancer-predisposition genes....Pages 16-39
From chromosomes to genes: how to isolate cancer-predisposition genes....Pages 40-55
Front Matter....Pages 57-57
Retinoblastoma: the paradigm for a genetically inherited cancer syndrome....Pages 58-69
Neurofibromatosis (NF) types 1 and 2....Pages 70-97
Multiple endocrine neoplasia....Pages 98-104
Wilms tumour and other genetic causes of renal cancer....Pages 105-122
The Li-Fraumeni syndrome and the role of TP 53 mutations in predisposition to cancer....Pages 123-135
Front Matter....Pages 137-137
Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients....Pages 138-151
Fanconi’s anaemia....Pages 152-163
The Gorlin (nevoid basal cell carcinoma) syndrome....Pages 164-184
Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer....Pages 185-206
Front Matter....Pages 207-207
Genetics and the common cancers....Pages 208-226
Familial breast cancer....Pages 227-238
The breast-ovarian cancer syndrome and BRCA 1....Pages 239-252
Screening for breast cancer in high-risk populations....Pages 253-266
The management of women with a high risk of breast cancer....Pages 267-281
Psychological distress associated with genetic breast cancer risk....Pages 282-289
Familial ovarian cancer....Pages 290-296
Familial colon cancer syndromes and their clinical management....Pages 297-305
Front Matter....Pages 207-207
The genetics of familial colon cancer....Pages 306-319
Familial prostate cancer and its management....Pages 320-332
Familial melanoma and its management....Pages 333-343
Familial predisposition to lung cancer....Pages 344-353
Front Matter....Pages 355-355
The cancer family clinic....Pages 356-371
Screening for mutations in cancer predisposition genes....Pages 372-382
The ethics of testing for cancer-predisposition genes....Pages 383-393
Back Matter....Pages 394-407