G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening

Content: 
Series Page
Page ii

Copyright
Page iv

Contributors
Pages xiii-xvii

Preface
Page xix
P. Michael Conn

Methods in Enzymology
Pages xxi-lvi

Chapter One - The Protein Local Optimization Program and G-Protein-Coupled Receptors: Loop Restoration and Applications to Homology Modeling
Pages 1-20
Dahlia A. Goldfeld, Richard A. Friesner

Chapter Two - Modeling Active GPCR Conformations
Pages 21-35
Bruck Taddese, Lisa M. Simpson, Ian D. Wall, Frank E. Blaney, Christopher A. Reynolds

Chapter Three - Molecular Modeling of Adenosine Receptors
Pages 37-59
Adriano Martinelli, Gabriella Ortore

Chapter Four - Predicting G-Protein-Coupled Receptors Families Using Different Physiochemical Properties and Pseudo Amino Acid Composition
Pages 61-79
Zia-ur Rehman, Muhammad Tayyeb Mirza, Asifullah Khan, Henri Xhaard

Chapter Five - Computational Design and Experimental Characterization of GPCR Segment Models
Pages 81-95
Abby L. Parrill

Chapter Six - G-Protein-Coupled Receptor Interaction with Small GTPases
Pages 97-108
Chunmin Dong, Guangyu Wu

Chapter Seven - Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G-Protein-Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
Pages 109-131
Annie Barbeau, Antoine G. Godin, Jody L. Swift, Yves De Koninck, Paul W. Wiseman, Jean-Martin Beaulieu

Chapter Eight - NMR Methods for Detection of Small Molecule Binding to RGS4
Pages 133-152
Andrew J. Storaska, Richard R. Neubig

Chapter Nine - Group II Activators of G-protein Signaling: Monitoring the Interaction of GО± with the G-protein Regulatory Motif in the Intact Cell
Pages 153-167
Sukru Sadik Oner, Joe B. Blumer, Stephen M. Lanier

Chapter Ten - Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
Pages 169-189
Adam M. Knepp, Thomas P. Sakmar, Thomas Huber

Chapter Eleven - cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
Pages 191-207
Jesper Mosolff Mathiesen, Line Vedel, Hans Bräuner-Osborne

Chapter Twelve - Rhodopsin–Lipid Interactions Studied by NMR
Pages 209-227
Olivier Soubias, Klaus Gawrisch

Chapter Thirteen - Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity
Pages 229-262
Kathryn M. Appleton, Mi-Hye Lee, Christian Alele, Christine Alele, Deirdre K. Luttrell, Yuri K. Peterson, Thomas A. Morinelli, Louis M. Luttrell

Chapter Fourteen - Application of Monte Carlo-Based Receptor Ensemble Docking to Virtual Screening for GPCR Ligands
Pages 263-278
Santiago Vilar, Stefano Costanzi

Chapter Fifteen - From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands
Pages 279-336
Albert J. Kooistra, Luc Roumen, Rob Leurs, Iwan J.P. de Esch, Chris de Graaf

Chapter Sixteen - Kinetics and Dynamics in the G Protein-Coupled Receptor Signaling Cascade
Pages 337-363
Jean-Pierre Vilardaga, Guillermo Romero, Timothy N. Feinstein, Vanessa L. Wehbi

Chapter Seventeen - Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
Pages 365-389
Joseph Goncalves, Markus Eilers, Kieron South, Chikwado A. Opefi, Philippe Laissue, Philip J. Reeves, Steven O. Smith

Chapter Eighteen - Posttranslation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
Pages 391-408
Hui Zheng, Horace H. Loh, Ping-Yee Law

Chapter Nineteen - Protein S-Nitrosylation Measurement
Pages 409-425
Yu Qin, Anindya Dey, Yehia Daaka

Author Index
Pages 427-455

Subject Index
Pages 457-472