Functional ultrastructure.

cover
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contents
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0002-3 structural organisation of a mammalian cell......Page 16
0004-5 architecture of the cell nucleus......Page 18
0006-7 cytochemical detection of ribonucleoproteins & nuclear lamina......Page 20
0008-9 detection of sites of DNA replication and of interphase chromosome domains......Page 22
0010-11 nucleolus......Page 24
0012-13 changes of the nucleolar architecture......Page 26
0014-15 detection of sites of RNA synthesis......Page 28
0016-17 nuclear pore complexes......Page 30
0018-19 nuclear pore complexes - structural changes as monitored by time-lapse atomic force microscopy......Page 32
0020-21 mitosis and cell division......Page 34
0022-23 apoptosis & viral inclusions......Page 36
0024-25 secretory pathway of pancreatic acinar cells......Page 38
0026-27 ribosomes, rough endoplasmic reticulum......Page 40
0028-29 nuclear envelope and rough endoplasmic reticulum......Page 42
0030-31 rough endoplasmic reticulum - site of protein translocation and initiation of protein n-glycosylation......Page 44
0032-33 oligosaccharide trimming, reglucosylation, and protein quality control in the rough endoplasmic reticulum......Page 46
0034-35 rough endoplasmic reticulum - storage site of aggregates of misfolded glycoproteins......Page 48
0036-37 russell bodies and aggresomes represent different types of protein inclusion bodies......Page 50
0038-39 smooth endoplasmic reticulum......Page 52
0040-41 proliferation of the smooth endoplasmic reticulum......Page 54
0042-43 pre-golgi intermediates......Page 56
0044-45 pre-golgi intermediates - oligosaccharide trimming and protein quality control......Page 58
0046-47 golgi apparatus - a main crossroads along secretory pathways......Page 60
0048-49 protein secretion visualised by immunoelectron microscopy......Page 62
0050-51 protein n-glycosylation - oligosaccharide trimming in the golgi apparatus and pre-golgi intermediates......Page 64
0052-53 golgi apparatus - site of maturation of asparagine-linked oligosaccharides......Page 66
0054-55 cell-type-related variations in the topography of golgi apparatus glycosylation reactions......Page 68
0056-57 cell-type-related differences in oligosaccharide structure......Page 70
0058-59 topography of biosynthesis of serine-threonine-linked oligosaccharides......Page 72
0060-61 golgi apparatus and tgn — secretion and endocytosis......Page 74
0062-63 golgi apparatus, tgn and trans-golgi-er......Page 76
0064-65 golgi apparatus, tgn and trans-golgi-er - tilt series......Page 78
0066-67 brefeldin a-induced disassembly of the golgi apparatus......Page 80
0068-69 brefeldin a-treatement - tubulation of golgi apparatus and endosomes......Page 82
0070-71 brefeldin a-treatement - effect on retrograde transport of internalised wga......Page 84
0072-73 brefeldin a-treatement - transitional er-elements and pre-golgi intermediates......Page 86
0074-75 heat shock response of the golgi apparatus......Page 88
0076-77 changes of the golgi apparatus upon atp-depletion and atp-replenishment......Page 90
0078-79 secretory granules......Page 92
0080-81 secretory granule types......Page 94
0082-83 receptor-mediated endocytosis via clathrin-coated vesicles and virus internalisation......Page 96
0084-85 endosomes and endocytic pathways......Page 98
0086-87 endocytic trans-golgi network and retrograde traffic into the golgi apparatus......Page 100
0088-89 tubular pericentriolar endosomes......Page 102
0090-91 langerhans cells and birbeck granules - antigen presenting dendritic cells of the epidermis......Page 104
0092-93 caveolae......Page 106
0094-95 fluid-phase endocytosis and phagocytosis......Page 108
0096-97 lysosomes......Page 110
0098-99 lysosomes - localisation of acid phosphatase, lamp and polylactosamin......Page 112
0100-101 i-cell disease......Page 114
0102-103 gaucher’s disease......Page 116
0104-105 fabry’s disease......Page 118
0106-107 gm2 gangliosidoses......Page 120
0108-109 farber’s disease......Page 122
0110-111 wolman’s disease......Page 124
0112-113 glycogenosis type II & cystinosis......Page 126
0114-115 autophagosomes - organelles for limited self-digestion......Page 128
0116-117 mitochondria - crista and tubulus-types......Page 130
0118-119 abnormalities of mitochondria......Page 132
0120-121 peroxisomes - multitalented organelles......Page 134
0122-123 peroxisome biogenesis......Page 136
0124-125 peroxisomes - adaptive changes......Page 138
0126-127 peroxisomal diseases......Page 140
0128-129 glycogen & glycogenosis type I......Page 142
0130-131 erythropoietic protoporphyria......Page 144
0132-133 cytocentre, centrosome, and microtubules......Page 146
0134-135 effects of microtubule disruption......Page 148
0136-137 actin filaments......Page 150
0138-139 intermediate filaments......Page 152
0140-141 mallory bodies......Page 154
0142-143 the plasma membrane......Page 156
0144-145 cells in culture......Page 158
0146-147 brush cell......Page 160
0148-149 glycocalyx (cell coat)......Page 162
0150-151 glycocalyx - cell type specificity and domains......Page 164
0152-153 glycocalyx changes in tumours......Page 166
0154-155 junctional complex......Page 168
0156-157 tight junctions and gap junctions......Page 170
0158-159 spot desmosomes......Page 172
0160-161 cellular interdigitations......Page 174
0162-163 basal labyrinth......Page 176
0164-165 basement membrane......Page 178
0166-167glomerular basement membrane & Alport’s syndrome (hereditary nephritis)......Page 180
0168-169 descemet’s membrane......Page 182
0170-171 skin basement membrane and keratinocyte hemidesmosomes - an epithel-connective tissue junctional complex......Page 184
0172-174 epidermolysis bullosa simplex......Page 186
0176-177 pancreatic acinus......Page 189
0178-179 acinar centre - acinar and centroacinar cells......Page 191
0180-181 pancreatic intercalated duct......Page 193
0182-183 submandibular gland......Page 195
0184-185 parietal cells of stomach - secretion of acid......Page 197
0186-187 intercalated cells of kidney - important regulators of acid-base balance......Page 199
0188-189 endocrine secretion - insulin-producing beta cells of islets of langerhans......Page 201
0190-191 impaired insulin processing in human insulinoma......Page 203
0192-193 cells of the disseminated endocrine system......Page 205
0194-195 liver epithelium......Page 207
0196-197 liver epithelium - bile canaliculi......Page 209
0198-199 liver epithelium - pathway of secretory lipoprotein particles......Page 211
0200-201 choroid plexus ependyma......Page 213
0202-203 small intestine - absorptive cells......Page 215
0204-205 small intestine - pathway of lipids......Page 217
0206-207 renal proximal tubule - a reabsorption plant......Page 219
0208-209 parathyroid hormone response of renal proximal tubules......Page 221
0210-211 photoreceptor cells of the retina - signalling of light......Page 223
0212-213 photoreceptor cells of the retina - light-induced apoptosis......Page 225
0214-215 corneal epithelium......Page 227
0216-217 epidermis......Page 229
0218-219 differentiation of keratinocytes and formation of the epidermal fluid barrier......Page 231
0220-221 the tracheo-bronchial epithelium......Page 233
0222-223 ciliary pathology - immotile cilia syndrome and kartagener syndrome......Page 235
0224-225 alveoli - gas exchange and host defense......Page 237
0226-227 umbrella cell — surface specialisations......Page 239
0228-229 umbrella cell — fusiform vesicles......Page 241
0230-231 continuous capillary, weibel-palade bodies......Page 243
0232-233 fenestrated capillary......Page 245
0234-235 endothelio-pericyte and endothelio-smooth muscle cell interactions......Page 247
0236-237 glomerulus - a specialised device for filtering......Page 249
0238-239 pathology of the glomerular filter - minimal change glomerulopathy and congenital nephrotic syndromes......Page 251
0240-241 pathology of the glomerulus - membranous glomerulonephritis......Page 253
0242-243 pathology of the glomerulus - membranoproliferative glomerulonephritis......Page 255
0244-245 pathology of the glomerulus - chronic allograft glomerulopathy......Page 257
0246-247 loose connective tissue......Page 259
0248-249 fibroblast, fibrocyte, macrophage......Page 261
0250-251 collagen and elastic fibres......Page 263
0252-253 eosinophilic granulocyte, plasma cell, macrophage, mast cell......Page 265
0254-255 dense connective tissue - collagen bundles in the cornea......Page 267
0256-257 bowman’s layer......Page 269
0258-259 amyloidosis of kidney......Page 271
0260-261 amyloid fibrils - growth as seen by time lapse, atomic force microscopy......Page 273
0262-263 articular cartilage......Page 275
0264-265 osteoblasts and osteocytes......Page 277
0266-267 osteoclast......Page 279
0268-269 myofibrils and sarcomere......Page 281
0270-271 sarcoplasmic reticulum, triad, satellite cell......Page 283
0272-273 neuromuscular junction......Page 285
0274-275 muscular dystrophies......Page 287
0276-277 myofibrils, intercalated disk......Page 289
0278-279 smooth muscle cells, synapse a distance......Page 291
0280-281 cadasil......Page 293
0282-183 central nervous system - neuron, glial cells......Page 295
0284-285 blood-brain barrier, synapses......Page 297
0286-287 unmyelinated nerve fibre......Page 299
0288-289 peripheral nerve - connective tissue components......Page 301
0290-291 myelinated nerve fibre, myelin......Page 303
0292-293 node of ranvier......Page 305
0294-295 axonal degeneration......Page 307
0296-297 neuroaxonal dystrophy......Page 309
0298-299 neuropathies associated with dysproteinaemias......Page 311
0300-301 metachromatic leukodystrophy......Page 313
0302-303 neuronal ceroid lipofuscinosis......Page 315
0304-305 red blood cells and cells of the erythroid lineage......Page 317
0306-307 neutrophilic granulocyte......Page 319
0308-309 eosinophilic granulocyte......Page 321
0310-311 monocyte......Page 323
0312-313 lymphocyte......Page 325
0314-315 megakaryocyte and thrombocyte......Page 327
0316-317 thrombocytes......Page 329
index......Page 331