Functional Ultrastructure: An Atlas of Tissue Biology and Pathology

Structural Organisation of a Mammalian Cell....Pages 2-3
Architecture of the Cell Nucleus....Pages 4-5
Cytochemical Detection of Ribonucleoproteins....Pages 6-6
Nuclear Lamina....Pages 6-7
Detection of Sites of DNA Replication and of Interphase Chromosome Domains....Pages 8-9
Nucleolus....Pages 10-11
Changes of the Nucleolar Architecture....Pages 12-13
Detection of Sites of RNA Synthesis....Pages 14-15
Nuclear Pore Complexes....Pages 16-17
Nuclear Pore Complexes: Structural Changes as Monitored by Time-Lapse Atomic Force Microscopy....Pages 18-19
Mitosis and Cell Division....Pages 20-21
Apoptosis....Pages 22-22
Viral Inclusions....Pages 22-23
Secretory Pathway of Pancreatic Acinar Cells....Pages 24-25
Ribosomes, Rough Endoplasmic Reticulum....Pages 26-27
Nuclear Envelope and Rough Endoplasmic Reticulum....Pages 28-29
Rough Endoplasmic Reticulum: Site of Protein Translocation and Initiation of Protein N -Glycosylation....Pages 30-31
Oligosaccharide Trimming, Reglucosylation, and Protein Quality Control in the Rough Endoplasmic Reticulum....Pages 32-33
Rough Endoplasmic Reticulum: Storage Site of Aggregates of Misfolded Glycoproteins....Pages 34-35
Russell Bodies and Aggresomes Represent Different Types of Protein Inclusion Bodies....Pages 36-37
Smooth Endoplasmic Reticulum....Pages 38-39
Proliferation of the Smooth Endoplasmic Reticulum....Pages 40-41
Pre-Golgi Intermediates....Pages 42-43
Pre-Golgi Intermediates: Oligosaccharide Trimming and Protein Quality Control....Pages 44-45
Golgi Apparatus: A Main Crossroads Along Secretory Pathways....Pages 46-47
Protein Secretion Visualised by Immunoelectron Microscopy....Pages 48-49
Protein N -Glycosylation: Oligosaccharide Trimming in the Golgi Apparatus and Pre-Golgi Intermediates....Pages 50-51
Golgi Apparatus: Site of Maturation of Asparagine-Linked Oligosaccharides....Pages 52-53
Cell-Type-Related Variations in the Topography of Golgi Apparatus Glycosylation Reactions....Pages 54-55
Cell-Type-Related Differences in Oligosaccharide Structure....Pages 56-57
Topography of Biosynthesis of Serine/Threonine-Linked Oligosaccharides....Pages 58-59
Golgi Apparatus and TGN — Secretion and Endocytosis....Pages 60-61
Golgi Apparatus, TGN and trans -Golgi-ER....Pages 62-63
Golgi Apparatus, TGN and trans -Golgi-ER: Tilt Series....Pages 64-65
Brefeldin A-Induced Disassembly of the Golgi Apparatus....Pages 66-67
Brefeldin A-Treatment: Tubulation of Golgi Apparatus and Endosomes....Pages 68-69
Brefeldin A-Treatment: Effect on Retrograde Transport of Internalised WGA....Pages 70-71
Brefeldin A-Treatment: Transitional ER-Elements and Pre-Golgi Intermediates....Pages 72-73
Heat Shock Response of the Golgi Apparatus....Pages 74-75
Changes of the Golgi Apparatus Upon ATP-Depletion and ATP-Replenishment....Pages 76-77
Secretory Granules....Pages 78-79
Secretory Granule Types....Pages 80-81
Receptor-Mediated Endocytosis Via Clathrin-Coated Vesicles and Virus Internalisation....Pages 82-83
Endosomes and Endocytic Pathways....Pages 84-85
Endocytic Trans -Golgi Network and Retrograde Traffic into the Golgi Apparatus....Pages 86-87
Tubular Pericentriolar Endosomes....Pages 88-89
Langerhans Cells and Birbeck Granules: Antigen Presenting Dendritic Cells of the Epidermis....Pages 90-91
Caveolae....Pages 92-93
Fluid-Phase Endocytosis and Phagocytosis....Pages 94-95
Lysosomes....Pages 96-97
Lysosomes: Localisation of Acid Phosphatase, Lamp and Polylactosamin....Pages 98-99
I-Cell Disease....Pages 100-101
Gaucher’s Disease....Pages 102-103
Fabry’s Disease....Pages 104-105
G M2 Gangliosidoses....Pages 106-107
Farber’s Disease....Pages 108-109
Wolman’s Disease....Pages 110-111
Glycogenosis Type II....Pages 112-112
Cystinosis....Pages 112-113
Autophagosomes: Organelles for Limited Self-Digestion....Pages 114-115
Mitochondria: Crista and Tubulus-Types....Pages 116-117
Abnormalities of Mitochondria....Pages 118-119
Peroxisomes: Multitalented Organelles....Pages 120-121
Peroxisome Biogenesis....Pages 122-123
Peroxisomes: Adaptive Changes....Pages 124-125
Peroxisomal Diseases....Pages 126-127
Glycogen....Pages 128-128
Glycogenosis Type I....Pages 128-129
Erythropoietic Protoporphyria....Pages 130-131
Cytocentre, Centrosome, and Microtubules....Pages 132-133
Effects of Microtubule Disruption....Pages 134-135
Actin Filaments....Pages 136-137
Intermediate Filaments....Pages 138-139
Mallory Bodies....Pages 140-141
The Plasma Membrane....Pages 142-143
Cells in Culture....Pages 144-145
Brush Cell....Pages 146-147
Glycocalyx (Cell Coat)....Pages 148-149
Glycocalyx: Cell Type Specificity and Domains....Pages 150-151
Glycocalyx Changes in Tumours....Pages 152-153
Junctional Complex....Pages 154-155
Tight Junctions and Gap Junctions....Pages 156-157
Spot Desmosomes....Pages 158-159
Cellular Interdigitations....Pages 160-161
Basal Labyrinth....Pages 162-163
Basement Membrane....Pages 164-165
Glomerular Basement Membrane....Pages 166-166
Alport’s Syndrome (Hereditary Nephritis)....Pages 166-167
Descemet’s Membrane....Pages 168-169
Skin Basement Membrane and Keratinocyte Hemidesmosomes: An Epithel-Connective Tissue Junctional Complex....Pages 170-171
Epidermolysis Bullosa Simplex....Pages 172-173
Pancreatic Acinus....Pages 176-177
Acinar Centre: Acinar and Centroacinar Cells....Pages 178-179
Pancreatic Intercalated Duct....Pages 180-181
Submandibular Gland....Pages 182-183
Parietal Cells of Stomach: Secretion of Acid....Pages 184-185
Intercalated Cells of Kidney: Important Regulators of Acid-Base Balance....Pages 186-187
Endocrine Secretion: Insulin-Producing Beta Cells of Islets of Langerhans....Pages 188-189
Impaired Insulin Processing in Human Insulinoma....Pages 190-191
Cells of the Disseminated Endocrine System....Pages 192-193
Liver Epithelium....Pages 194-195
Liver Epithelium: Bile Canaliculi....Pages 196-197
Liver Epithelium: Pathway of Secretory Lipoprotein Particles....Pages 198-199
Choroid Plexus Ependyma....Pages 200-201
Small Intestine: Absorptive Cells....Pages 202-203
Small Intestine: Pathway of Lipids....Pages 204-205
Renal Proximal Tubule: A Reabsorption Plant....Pages 206-207
Parathyroid Hormone Response of Renal Proximal Tubules....Pages 208-209
Photoreceptor Cells of the Retina: Signalling of Light....Pages 210-211
Photoreceptor Cells of the Retina: Light-Induced Apoptosis....Pages 212-213
Corneal Epithelium....Pages 214-215
Epidermis....Pages 216-217
Differentiation of Keratinocytes and Formation of the Epidermal Fluid Barrier....Pages 218-219
The Tracheo-Bronchial Epithelium....Pages 220-221
Ciliary Pathology: Immotile Cilia Syndrome and Kartagener Syndrome....Pages 222-223
Alveoli: Gas Exchange and Host Defense....Pages 224-225
Umbrella Cell — Surface Specialisations....Pages 226-227
Umbrella Cell — Fusiform Vesicles....Pages 228-229
Continuous Capillary, Weibel-Palade Bodies....Pages 230-231
Fenestrated Capillary....Pages 232-233
Endothelio-Pericyte and Endothelio-Smooth Muscle Cell Interactions....Pages 234-235
Glomerulus: A Specialised Device for Filtering....Pages 236-237
Pathology of the Glomerular Filter: Minimal Change Glomerulopathy and Congenital Nephrotic Syndromes....Pages 238-239
Pathology of the Glomerulus: Membranous Glomerulonephritis....Pages 240-241
Pathology of the Glomerulus: Membranoproliferative Glomerulonephritis....Pages 242-243
Pathology of the Glomerulus: Chronic Allograft Glomerulopathy....Pages 244-245
Loose Connective Tissue....Pages 246-247
Fibroblast, Fibrocyte, Macrophage....Pages 248-249
Collagen and Elastic Fibres....Pages 250-251
Eosinophilic Granulocyte, Plasma Cell, Macrophage, Mast Cell....Pages 252-253
Dense Connective Tissue: Collagen Bundles in the Cornea....Pages 254-255
Bowman’s Layer....Pages 256-257
Amyloidosis of Kidney....Pages 258-259
Amyloid Fibrils: Growth as Seen by Time Lapse, Atomic Force Microscopy....Pages 260-261
Articular Cartilage....Pages 262-263
Osteoblasts and Osteocytes....Pages 264-265
Osteoclast....Pages 266-267
Myofibrils and Sarcomere....Pages 268-269
Sarcoplasmic Reticulum, Triad, Satellite Cell....Pages 270-271
Neuromuscular Junction....Pages 272-273
Muscular Dystrophies....Pages 274-275
Myofibrils, Intercalated Disk....Pages 276-277
Smooth Muscle Cells, Synapse Á Distance....Pages 278-279
CADASIL....Pages 280-281
Central Nervous System: Neuron, Glial Cells....Pages 282-283
Blood-Brain Barrier, Synapses....Pages 284-285
Unmyelinated Nerve Fibre....Pages 286-287
Peripheral Nerve: Connective Tissue Components....Pages 288-289
Myelinated Nerve Fibre, Myelin....Pages 290-291
Node of Ranvier....Pages 292-293
Axonal Degeneration....Pages 294-295
Neuroaxonal Dystrophy....Pages 296-297
Neuropathies Associated with Dysproteinaemias....Pages 298-299
Metachromatic Leukodystrophy....Pages 300-301
Neuronal Ceroid Lipofuscinosis....Pages 302-303
Red Blood Cells and cells of the Erythroid Lineage....Pages 304-305
Neutrophilic Granulocyte....Pages 306-307
Eosinophilic Granulocyte....Pages 308-309
Monocyte....Pages 310-311
Lymphocyte....Pages 312-313
Megakaryocyte and Thrombocyte....Pages 314-315
Thrombocytes....Pages 316-317