Functional ultrastructure : Atlas of tissue biology and pathology

Front Matter....Pages I-XVII
Front Matter....Pages 1-1
Structural Organisation of a Mammalian Cell....Pages 2-3
Architecture of the Cell Nucleus....Pages 4-5
Cytochemical Detection of Ribonucleoproteins....Pages 6-6
Nuclear Lamina....Pages 6-7
Detection of Sites of NA Replication and of Interphase Chromosome domains....Pages 8-9
Nucleolus....Pages 10-11
Changes of the Nucleolar Architecture....Pages 12-13
Detection of Sites of RNA Synthesis....Pages 14-15
Nuclear Pore Complexes....Pages 16-17
Nuclear Pore Complexes: Structural Changes as Monitored by Time-Lapse Atomic Force Microscopy....Pages 18-19
Mitosis and Cell Division....Pages 20-21
Apoptosis....Pages 22-22
Viral Inclusions....Pages 22-23
Secretory Pathway of Pancreatic Acinar Cells....Pages 24-25
Endomembrane System of Dinoflagellates....Pages 26-27
Ribosomes, Rough Endoplasmic Reticulum....Pages 28-29
Nuclear Envelope and Rough Endoplasmic Reticulum....Pages 30-31
Annulate Lamellae....Pages 32-33
Rough Endoplasmic Reticulum: Site of Protein Translocation and Initiation of Protein N-Glycosylation....Pages 34-35
Oligosaccharide Trimming, Reglucosylation, and Protein Quality Control in the Rough Endoplasmic Reticulum....Pages 36-37
Front Matter....Pages 1-1
Rough Endoplasmic Reticulum: Storage Site of Aggregates of Misfolded Glycoproteins....Pages 38-39
Russell Bodies and Aggresomes Represent Different Types of Protein Inclusion Bodies....Pages 40-41
Smooth Endoplasmic Reticulum....Pages 42-43
Proliferation of the Smooth Endoplasmic Reticulum....Pages 44-45
Pre-Golgi Intermediates....Pages 46-47
Pre-Golgi Intermediates: Oligosaccharide Trimming and Protein Quality control....Pages 48-49
Golgi Apparatus: A Main Crossroads Along Secretory Pathways....Pages 50-51
Protein Secretion Visualised by Immunoelectron Microscopy....Pages 52-53
Protein N -Glycosylation: Oligosaccharide Trimming in the Golgi Apparatus and Pre-Golgi Intermediates....Pages 54-55
Golgo Apparatus: Site of Maturation of Aspara Gine-Linked Oligo Saccharides....Pages 56-57
Cell Type-Related Variations in the Topography of Golgi Apparatus Glycosylation Reactions....Pages 58-59
Cell Type-Related Differences in Oligosaccharide Structure....Pages 60-61
Topography of Biosynthesis of Serine/Threonine-Linked Oligosaccharides....Pages 62-63
Golgi Apparatus and TGN — Structural Considerations....Pages 64-65
Golgi Apparatus and TGN — Secretion and Endocytosis....Pages 66-67
Golgi Apparatus, TGN and Trans Golgi-ER....Pages 68-69
Golgi Apparatus, TGN and Trans Golgi-ER: Tilt Series....Pages 70-71
Structure of the TGN....Pages 72-73
Brefeldin A-Induced Golgi Apparatus Disassembly....Pages 74-75
Brefeldin A-Treatment: Tubulation of Golgi Apparatus and Endosomes....Pages 76-77
Front Matter....Pages 1-1
Brefeldin A-Treatment: Effect on Retrograde Transport of Internalised WGA....Pages 78-79
Brefeldin A-Treatment: Transitional ER-Elements and Pre-Golgi Intermediates....Pages 80-81
Heat Shock Response of the Golgi Apparatus....Pages 82-83
Golgi Apparatus Changes Upon ATP-Depletion and ATP-Replenishment....Pages 84-85
Secretory Granules....Pages 86-87
Secretory Granule Types....Pages 88-89
Goblet Cell — Compound Exocytosis....Pages 90-91
Receptor-Mediated Endocytosis Via Clathrin-Coated Vesicles and Virus Endocytosis....Pages 92-93
Endosomes and Endocytic Pathways....Pages 94-95
Endocytic Trans Golgi Network and Retrograde Traffic into the Golgi Apparatus....Pages 96-97
Tubular Pericentriolar Endosomes....Pages 98-99
Langerhans Cells and Birbeck Granules: Antigen Presenting Dendritic Cells of the Epidermis....Pages 100-101
Caveolae....Pages 102-103
Fluid-Phase Endocytosis and Phagocytosis....Pages 104-105
Lysosomes....Pages 106-107
Lysosomes: Localisation of Acid Phosphatase, Lamp and Polylactosamine....Pages 108-109
I-Cell Disease....Pages 110-111
Gaucher’s disease....Pages 112-113
Fabry’s Disease....Pages 114-115
G M2 Gangliosidoses....Pages 116-117
Front Matter....Pages 1-1
Peroxisomes: Multitalented Organelles....Pages 132-133
Peroxisome Biogenesis....Pages 134-135
Peroxisomes: Adaptive Changes....Pages 136-137
Peroxisomal Disorders....Pages 138-139
Glycogen....Pages 140-140
Glycogenosis Type I....Pages 140-141
Erythropoietic Protoporphyria....Pages 142-143
Farber’s Disease....Pages 118-119
Wolman’s Disease....Pages 120-121
Glycogenosis Type II....Pages 122-122
Cystinosis....Pages 122-123
Cytocentre, Centrosome, and Microtubules....Pages 144-145
Effects of Microtubule Disruption....Pages 146-147
Actin Filaments....Pages 148-149
Intermediate Filaments....Pages 150-151
Mallory Bodies....Pages 152-153
Autophagy: Limited Self-Digestion....Pages 124-125
Pexophagy: Autophagy of Peroxisomes....Pages 126-127
Mitochondria: Crista and Tubulus Types....Pages 128-129
Abnormalities of Mitochondria....Pages 130-131
Front Matter....Pages 1-1
The Plasma Membrane....Pages 154-155
Cells in Culture....Pages 156-157
Brush Cell....Pages 158-159
Glycocalyx (Cell Coat)....Pages 160-161
Glycocalyx: Cell Type Specificity and Domains....Pages 162-163
Glycocalyx Changes in Tumours....Pages 164-165
Junctional Complex....Pages 166-167
Tight Junctions and Gap Junctions....Pages 168-169
Tunneling Nanotubes....Pages 170-171
Spot Desmosomes....Pages 172-173
Selectin — Ligand-Mediated Cell-Cell Interaction....Pages 174-175
Cellular Interdigitations....Pages 176-177
Basal Labyrinth....Pages 178-179
Basement Membrane....Pages 180-181
Glomerular Basement Membrane....Pages 182-182
Alport’S Syndrome (Hereditary Nephritis)....Pages 182-183
Descemet’s Membrane....Pages 184-185
Skin Basement Membrane and Keratinocyte Hemidesmosomes: An Epithel-Connective Tissue Junctional Complex....Pages 186-187
Epidermolysis Bullosa Simplex....Pages 188-189
Front Matter....Pages 191-191
Pancreatic Acinus....Pages 192-193
Front Matter....Pages 191-191
Acinar Centre: Acinar and Centroacinar Cells....Pages 194-195
Pancreatic Intercalated Duct....Pages 196-197
Submandibular Gland....Pages 198-199
Goblet Cells — Unicellular Glands....Pages 200-201
Parietal Cells of Stomach: Secretion of Acid....Pages 202-203
Intercalated Cells of Kidney: Important Regulators of Acid-Base Balance....Pages 204-205
Endocrine Secretion: Insulin-Producing Beta Cells of Islets of Langerhans....Pages 206-207
Impaired Insulin Processing in Human Insulinoma....Pages 208-209
Cells of the Disseminated Endocrine System....Pages 210-211
Liver....Pages 212-213
Liver: Hepatocytes, Kupffer cell, Cell of Ito....Pages 214-215
Liver Epithelium: Bile Canaliculi....Pages 216-217
Liver Epithelium: Pathway of Secretory Lipoprotein Particles....Pages 218-219
Congenital Hepatic Fibrosis....Pages 220-221
Choroid Plexus Ependyma....Pages 222-223
Small Intestine: Absorptive Cells....Pages 224-225
Small Intestine: Pathway of Lipids....Pages 226-227
Renal Proximal Tubule: A Reabsorption Plant....Pages 228-229
Parathyroid Hormone Response of Renal Proximal Tubules....Pages 230-231
Photoreceptor Cells of the Retina: Signalling of Light....Pages 232-233
Front Matter....Pages 191-191
Continuous Capillary, Weibel-Palade Bodies....Pages 254-255
Hyaline Arteriolosclerosis....Pages 256-257
Fenestrated Capillary....Pages 258-259
Endothelio-Pericyte and Endothelio-Smooth Muscle Cell Interactions....Pages 260-261
Photoreceptor Cells of the Retina: Light-Induced Apoptosis....Pages 234-235
Olfactory Epithelium....Pages 236-237
Corneal Epithelium....Pages 238-239
Epidermis....Pages 240-241
Differentiation of Keratinocytes and Formation of the Epidermal Fluid Barrier....Pages 242-243
The Tracheo-Bronchial Epithelium....Pages 244-245
Ciliary Pathology: Immotile Cilia Syndrome and Kartagener Syndrome....Pages 246-247
Alveoli: Gas Exchange and Host Defense....Pages 248-249
Glomerulus: A Specialised Device for Filtering....Pages 262-263
Pathology of the Glomerular Filter: Minimal Change Glomerulopathy and Congenital Nephrotic Syndromes....Pages 264-265
Pathology of the Glomerulus: Membranous Glomerulonephritis....Pages 266-267
Pathology of the Glomerulus: Membranoproliferative Glomerulonephritis....Pages 268-269
Pathology of the Glomerulus: IgA Nephropathy (Berger)....Pages 270-271
Pathology of the Glomerulus: Chronic Allograft Glomerulopathy....Pages 272-273
Umbrella Cell — Surface Specialisations....Pages 250-251
Umbrella Cell — Fusiform Vesicles....Pages 252-253
Front Matter....Pages 191-191
Articular Cartilage....Pages 294-295
White Adipose Tissue....Pages 290-291
Brown Adipose Tissue....Pages 292-293
Myofibrils, Intercalated Disk....Pages 310-311
Osteoblasts and Osteocytes....Pages 296-297
Osteoclast....Pages 298-299
Loose Connective Tissue....Pages 274-275
Fibroblast, Fibrocyte, Macrophage....Pages 276-277
Collagen and Elastic Fibres....Pages 278-279
Eosinophilic Granulocyte, Plasma Cell, Macrophage, Mast Cell....Pages 280-281
Dense Connective Tissue: Collagen Bundles in the Cornea....Pages 282-283
Bowman’s Layer....Pages 284-285
Amyloidosis of Kidney....Pages 286-287
Amyloid Fibrils: Growth as Seen by Time Lapse, Atomic Force Microscopy....Pages 288-289
Myofibrils and Sarcomere....Pages 300-301
Sarcoplasmic Reticulum, Triad, Satellite Cell....Pages 302-303
Neuromuscular Junction....Pages 304-305
Muscular Dystrophies....Pages 306-307
Glycogenosis Type II (Pompe)....Pages 308-309
Smooth Muscle Cells, Synapse Á Distance....Pages 312-313
Front Matter....Pages 191-191
CADASIL....Pages 314-315
Central Nervous System: Neuron, Glial Cells....Pages 316-317
Blood-Brain Barrier, Synapses....Pages 318-319
Structure of the Synaptic Terminal....Pages 320-321
Unmyelinated Nerve Fibre....Pages 322-323
Peripheral Nerve: Connective Tissue Components....Pages 324-325
Myelinated Nerve Fibre, Myelin....Pages 326-327
Node of Ranvier....Pages 328-329
Axonal Degeneration....Pages 330-331
Neuroaxonal Dystrophy....Pages 332-333
Neuropathies Associated with Dysproteinaemias....Pages 334-335
Metachromatic Leukodystrophy....Pages 336-337
Neuronal Ceroid Lipofuscinosis....Pages 338-339
Red Blood Cells and Cells of the Erythroid Lineage....Pages 340-341
Neutrophilic Granulocyte....Pages 342-343
Eosinophilic Granulocyte....Pages 344-345
Basophilic Granulocyte....Pages 346-347
Monocyte....Pages 348-349
Lymphocyte....Pages 350-351
Megakaryocyte and Thrombocyte....Pages 352-353
Front Matter....Pages 191-191
Thrombocytes....Pages 354-355
Back Matter....Pages 357-366