Function and Structure of the Immune System

Front Matter....Pages i-xxi
Introductory Remarks....Pages 1-9
Front Matter....Pages 11-11
Introduction — On the 20th Anniversary of a Scientific Discovery....Pages 13-17
Ontogenetic Differentiation of Epithelial and Non-Epithelial Cells in the Human Thymus....Pages 19-23
Antigenic Changes Associated with Chicken B Lymphocyte Development....Pages 25-30
Evidence for Surface Antigen(s) Specific for a Subpopulation of Peripheral B and T Lymphocytes in the Chicken....Pages 31-35
Separation of Germinal Centres from Chicken Spleen....Pages 37-41
Germinal Centres and the B-Cell System: A Search for the Germinal Centre Precursor Cell in the Rat....Pages 43-49
Migratory Patterns of the Ly Subsets of T Lymphocytes in the Mouse....Pages 51-54
Correlation of Immunogenetic and Histological Changes in Imnunodeficient Mutant hr/hr Mice....Pages 55-58
Morphology of the Extrafollicular Zone and Pseudo-Follicles of the Rat Lymph Node, and Their Role in Lymphocyte Traffic....Pages 59-64
Lymphocyte-High Endothelial Venule Interactions: Examination of Species Specificity....Pages 65-72
Basic Mechanisms of Lymphocyte Recirculation in Lewis Rats....Pages 73-83
The Effect of Cytoskeletal Inhibitors on the Migration of Lymphocytes across Vascular Endothelium....Pages 85-91
New Evidence on Control Mechanisms in Lymphocyte Traffic....Pages 93-99
Separation of Earthworm Coelomocytes by Velocity Sedimentation....Pages 101-106
Two Subpopulations of Cortisone-Resistant Lymphoid Cells in the Rabbit Thymus....Pages 107-112
Development of an Isotope Dilution Assay to Determine the T-Cell Mass in Guinea Pigs....Pages 113-117
Lymphocyte Production and Organ Distribution of Newly Formed Lymphocytes after Selective 3 H-Deoxycytidine Labelling of Mesenteric Lymph Nodes....Pages 119-123
Germinal Centers and the B-Cell System: B Cell Differentiation in Rabbit Appendix Germinal Centers....Pages 125-131
The Influence of the Thymus upon the Number and Class Distribution of Immunoglobulin Containing Cells in the Bone Marrow and Other Lymphoid Organs of the Mouse....Pages 133-138
Front Matter....Pages 11-11
Summing-Up....Pages 139-142
Front Matter....Pages 143-143
Introduction — The Immunoglobulin-Like T Cell Receptor Problem....Pages 145-156
Isolation and Partial Identification of Immunoglobulin from T Cells....Pages 157-164
Codistribution of Antigen and Fab Determinants on Thymic Antigen-Binding Cells....Pages 165-171
Ontogeny of Spontaneous Rosette Forming Cells in Mice....Pages 173-179
Multiple Ig Classes on Rabbit B Lymphocytes....Pages 181-185
C3 Receptors and Membrane Complement Components on Lymphocytes Jointly Cause Binding of EAC....Pages 187-188
C3 and C5 Compete for the Same Binding Site on Complement Receptor Cells....Pages 189-190
Inhibition of C3b and C3d Receptor Activity by Xenoantisera Prepared by Immunization with Cell-Bound C3 Receptor Protein....Pages 191-194
Modulation of the Immune Response by Pretreatment of Antigen with Complement....Pages 195-198
Characterization of an IgG-Fc Receptor Protein Isolated from Human B-Prolymphocytic and B-Chronic Lymphocytic Leukemia Cells....Pages 199-205
Antisera Cause Alterations in Morphology and Enzyme Activity in the Plasma Membrane of Rat Thymocytes....Pages 207-212
Modulation of Cell Membrane Antigens during Differentiation of Rat T-Lymphocytes....Pages 213-217
Interactions between Neuraminidase-Treated Lymphocytes and Liver Cells....Pages 219-222
Immunological Characteristics of Neo-Antigens on the Cell Surface after Neuraminidase Treatment....Pages 223-227
Carbohydrate Incorporation into Glycoconjugates of Mouse Thymocytes during Con A Stimulation — Involvement of Two Subpopulations....Pages 229-232
Are Endogenous C-Type Viruses Physiologically Required for the Regulation of the Humoral Immune Response?....Pages 233-237
Plating Inhibition Assay (PIA): A New Test for Cell Mediated Cytotoxicity....Pages 239-242
Summing-Up — Lymphocyte Receptors....Pages 243-244
Front Matter....Pages 245-245
Introduction....Pages 247-251
Front Matter....Pages 245-245
Differentiation of B Cells and the Clonal Abortion Theory....Pages 253-258
Permanent Abolition of Reactivity to Major Histocompatibility Antigens Requires Elimination of Prethymic Precursors....Pages 259-265
Survival and Immunological Responsiveness of Rat-Mouse Bone Marrow Chimeras....Pages 267-271
The Control of Autoreactive Lymphocytes by a Receptor Blockade Mechanism....Pages 273-279
Stimulation of Natural Antibodies by Self Antigens....Pages 281-288
The Role of Antigen-Antibody Complexes in Generating Immunological Memory and Auto-Antiidiotypic Immunity....Pages 289-294
Germinal Center Formation in BSA-Tolerant Chickens....Pages 295-299
Studies of Allospecific Suppressor Cells in Culture....Pages 301-306
Regulation of Delayed Type Hypersensitivity to Sheep Red Blood Cells: Demonstration of Suppressor T Cells and a Soluble Suppressor Factor....Pages 307-311
Induction of Tolerance to DNCB-Contact Sensitivity in Guinea Pig Fetuses....Pages 313-317
Suppressor Cells for In Vivo Cytotoxic Responses — Regulation of the In Vivo Activation of Cytotoxic T-Lymphocytes by Suppressor Cells....Pages 319-325
Demonstration of Cell Mediated Autoimmunity and Induction of a Suppressive Control Mechanism....Pages 327-332
Suppressor T Cells in Induction and Maintenance of Low Zone Tolerance to Bovine Serum Albumin....Pages 333-338
Cation-Induced Immunosuppression: The Effect of Lithium on Arthus Reactivity, Delayed Hypersensitivity and Antibody Production in the Rat....Pages 339-344
Characterization of Reactive and Suppressive Cells in the Mouse Embryonic Liver by Peanut Agglutinin (PNA)....Pages 345-350
The Effect of Adjuvant Induced Suppressor Cells on in Vitro and in Vivo Lymphocyte Responses....Pages 351-355
Middle Ear Transplantation: A New Concept in Clinical Otology....Pages 357-362
Summing-Up — Immunological Tolerance (Suppression/Deletion)....Pages 363-365
Front Matter....Pages 367-367
Introduction — Heterogeneity of the Cellular Immune Response....Pages 369-374
Mast Cells in Local Antibody Formation and Allograft Rejection....Pages 375-379
Front Matter....Pages 367-367
Marginal Zone and Marginal Sinus Macrophages in the Mouse are Distinct Populations....Pages 381-388
Cells Containing Birbeck Granules in the Lymph and the Lymph Node....Pages 389-394
Macrophage-Lymphocyte Interaction Following Concanavalin A-Stimulation as Monitored by Chemiluminescence....Pages 395-399
Cell Cooperations in the Mitogen-Induced Transformation of Human Blood Lymphocytes in Healthy Persons and in Hodgkin’s Disease....Pages 401-405
The Antigen Binding Dendritic Cell of the Lymphoid Follicles: Evidence Indicating Its Role in the Maintenance and Regulation of Serum Antibody Levels....Pages 407-410
The Concept of Drug-Carriers in the Treatment of Parasitic Diseases....Pages 411-412
Recycling (Shuttle) of Cell Surface Membrane during Endocytosis....Pages 413-414
The Effect of Various Prostaglandins on Plasma Membrane Receptors and Function of Mouse Macrophages....Pages 415-419
Modulation of Phagocytosis Induced Prostaglandin Release from Macrophages....Pages 421-426
Neoformation of Lymphatics in the Mouse Omentum....Pages 427-432
Properties of Mononuclear Phagocytes Derived from the Small Intestinal Wall of Rats....Pages 433-438
Graft-Versus-Host Induced Immunosuppression Associated with an Increased Thymic Mitogen Response....Pages 439-444
Thymic Microenvironment Changes Associated with Graft-Versus-Host Immunosuppression....Pages 445-449
Local Cellular Reactions Following Intracutaneous Injections of Various Adjuvants in Rats and Guinea-Pigs....Pages 451-457
Summing-Up....Pages 459-462
Front Matter....Pages 463-463
Studies on MIF and the Role of Macrophage Associated Esterases in the Response of the Macrophage to MIF....Pages 465-468
Chemical Characterization of Radiolabeled Lymphocyte Activation Products of Guinea Pig Associated with Macrophage Migration Inhibitory Activity (MIF)....Pages 469-474
Murine MIF Does Not Contain Ia Determinants....Pages 475-478
Different Cellular Site for the Production of Murine Macrophage Migration Inhibitory Factor and Immune Interferon (Type 11)....Pages 479-483
Biochemical Characterization of the Human Lymphokine Leukocyte Migration Inhibitory Factor (LIF): Role of cGMP as a Specific Inhibitor of the LIF Esterase Activity....Pages 485-490
Front Matter....Pages 463-463
Some Characteristics of the Antigen — Dependent Migration Inhibition Factor....Pages 491-496
A Mediator Acting as a Costimulator for the Development of Cytotoxic Responses In Vitro....Pages 497-501
Colony Stimulating Activity of Human Spleen Cell Culture Supernatants....Pages 503-510
Detection of Thymosin in Thymic Epithelial Cells by an Immunoperoxidase Method....Pages 511-515
Characterization of Thymus Extracts Which Stimulate Incorporation of Galactose into Glycoconjugates of Rat Bone Marrow Cells....Pages 517-520
Generation of an Eosinophilotactic Factor from Human PMNs by Various Mechanisms of Cell Activation....Pages 521-528
The Effect of Histamine on Lymphocytes: Release of an Inhibitor of Eosinophil Chemotactic Migration....Pages 529-532
Summing Up: Soluble Mediators of Immunity....Pages 533-537
Front Matter....Pages 539-539
Introduction — Functional and Morphological Aspects of Malignant Lymphomas....Pages 541-543
Multidisciplinary Study of Non-Hodgkin Lymphomas: Electron Microscopy, Immune- and Enzyme-Histochemistry....Pages 545-551
Correlation of Biochemical and Immunological Markers with Conventional Morphology and Clinical Features in 120 Patients with Malignant Lymphomas....Pages 553-560
Biology of Lymphoma Transformation....Pages 561-566
Demonstration of Intracytoplasmic Immunoglobulin, Lysozyme, and Albumin and Isoelectric Focusing Pattern of Tissue Immunoglobulin in So-Called Reticulum Cell Sarcoma (Immunoblastic or Large Cell Lymphoma)....Pages 567-572
Alkaline Phosphatase Positive Lymphomas and Lymphocytes....Pages 573-577
Definition of Germinal Center Cell-Derived Lymphomas by Analysis of Complement Receptor Subtypes and Morphological Criteria....Pages 579-583
Spleen Cell Populations in Hodgkin’s Disease....Pages 585-588
Isoelectric Focusing Pattern of Acid Phosphatase in Normal Splenic Tissue, in the Lysosomal Fraction of Viable Splenic Lymphocytes and in Cases of Hairy Cell Leukemia....Pages 589-592
A Molecular Approach Delineating Surface Markers on Human T-Lymphocytes....Pages 593-598
Effect of Thymic Humoral Factor (THF) In Vitro on Bone Marrow and Blood Cells from B, T and Null Cell Acute Lymphatic Leukemia (ALL)....Pages 599-603
Serum and Secretory Immunoglobulin Levels in Preleukaemic AKR Mice and Three Other Mouse Strains....Pages 605-612
Front Matter....Pages 539-539
Adult T Cell Leukemia. Histological Features of the Lymphoid Tissues....Pages 613-621
Membrane Glycoprotein Patterns of Normal and Malignant Human Leukocytes....Pages 623-628
In Vivo Activity of Lymphocytes Sensitized In Vitro by Antigen-Fed Macrophages: Inhibition of Lymphoma Growth....Pages 629-634
Summing-Up — Immunologic Markers in Human Malignant Lymphomas....Pages 635-640
Front Matter....Pages 641-641
Introduction — Immunopathology of Parasitic Diseases....Pages 643-645
Malaria Infection in Mice. Plasmodium Berghei Infection in Mice: A Model for Immune Complex Disease and Autoimmunity....Pages 647-654
Suppressor Cells in Trypanosoma Congolense-Infected Mice....Pages 655-660
Immune Depression in Trypanosoma Congolense-Infected Mice....Pages 661-666
Relevance of Polyclonal Antibody Formation to the Development of Autoimmunity: The Model of African Trypanosomiasis....Pages 667-671
In Vivo and In Vitro Interaction of Trypanosoma Cruzi with Mouse Macrophages and Heart Muscle Cells — Film Presentation....Pages 673-676
Comparison of the Ability of Eosinophils and Neutrophils, and of Eosinophils from Patients with S. Mansoni Infection and Normal Individuals, to Mediate In Vitro Damage to Schistosomula of S. Mansoni....Pages 677-682
Significance of Local Formation of Immune Complexes within Granulomata in Schistosomiasis....Pages 683-685
Thymus-Dependence and Kinetics of Intestinal Mast Cells and Globule Leucocytes....Pages 687-691
Inhibition of Lymphocyte Proliferation during Parasitic Infection with Nippostrongylus Brasiliensis....Pages 693-698
Immunopathology of M. Lepremurium (MLM) Infection in B6 C3AN and (C3HxB6) F1 Mice....Pages 699-702
Genetics and Mechanisms of Resistance or Susceptibility to Murine Listeriosis....Pages 703-707
Genetic Control of Susceptibility to T. Congolense Infection in Inbred Strains of Mice....Pages 709-714
Front Matter....Pages 715-715
Introduction — Immunological Reactions and Immunotherapy of Malignant Disease....Pages 717-725
Pregnancy-Associated Glycoprotein (α 2 -PAG) in the Sera of Children with Malignancies....Pages 727-731
Circulating Human T Cell Subset with a Reversible E-Rosetting Capacity in Cancer and Normals-Hypothesis on the Regulatory Mechanism Influencing Their Role in CMI....Pages 733-738
Front Matter....Pages 715-715
A Tumor T Cell Line Which Can Be Specifically Activated by Antigen....Pages 739-744
A Model of Target Cell Recognition and Lysis by Natural Killer Cells....Pages 745-750
The Stimulation of a T Cell Response in the Syngeneic Host by the P-815 Mastocytoma Cell and the Isolation of a Tumor-Associated Antigen Which Has Some H-2 Antigen Characteristics....Pages 751-756
Cytotoxic T Cell Responses to a Syngeneic Tumour: Conditions for Primary Activation In Vitro and Biological Activity In Vivo....Pages 757-761
Opposite Effects of T-Cells on Syngeneic Tumor Growth In Vivo: Tumor Inhibition by Mature Lymphocytes and Enhancement of the Same Tumors by Immature Cells....Pages 763-768
Tumor Metastases and Cell-Mediated Immunity in a Model System in DBA/2 Mice. 2. Characteristics of a Metastasizing Variant of a Chemically Induced Lymphoma....Pages 769-775
Characterization of Lymphocytes Invading Experimental Tumors....Pages 777-781
Functional Activity of Human Tumor-Infiltrating Macrophages....Pages 783-787
Approaches to Effective Tumor Immunotherapy with Cells and the Enzyme Neuraminidase....Pages 789-794
Summing-Up....Pages 795-797
Front Matter....Pages 799-799
Introduction....Pages 801-802
The Production and Role of Cytotoxic T Cells in Influenza Virus Infection in Mice: Do the Same Rules Apply in the Response to Any Foreign Antigen?....Pages 803-809
Virus Spike Protein Complexes and Virosomes as Effective Subunit Vaccines....Pages 811-816
Posttransfusion Hepatitis (PTH): Frequency, Serological Type and Possible Role of Pre-Existing Anti-HB s in Protection....Pages 817-821
Immunopathological Alterations of Lymphatic Tissues in Mice Infected with Lymphocytic Choriomeningitis Virus....Pages 823-826
Light and Electron Microscopic Characteristics of Sinus Reactions and Cellular Traffic in the Hilar Lymph Node Complex (HLNC) in Rabbits Undergoing a Pulmonary Cell-Mediated Immune Reaction....Pages 827-832
Peripheral Blood Lymphocyte Subpopulations in Multiple Myeloma....Pages 833-839
General Summary....Pages 841-843
Back Matter....Pages 845-850