Frontiers in Hypertension Research

Front Matter....Pages i-xxxix
Frontiers in Hypertension Research: Past, Present and Future Introduction....Pages 1-5
Front Matter....Pages 7-7
Position Paper: The Variation in Risk Among Hypertensive Patients: Is Broad Scale Therapy to Help Only a Few Justifiable? What Pressure Levels Should Be Treated....Pages 9-14
Interpretation of the Hypertension Detection and Follow-up Program....Pages 15-16
Implications of Framingham Study Data for Treatment of Hypertension: Impact of Other Risk Factors....Pages 17-21
Factors Affecting Morbidity and Mortality and the Risk Factor Concept....Pages 22-23
Australian Therapeutic Trial in Mild Hypertension....Pages 24-28
Treatment of Borderline and Mild Hypertension: The Oslo Study....Pages 29-34
Front Matter....Pages 35-35
Position Paper: Dietary Sodium and Human Hypertension....Pages 37-42
Sodium Deprivation as an Approach to Hypertension....Pages 43-45
Sodium and Other Dietary Factors in Experimental and Human Hypertension: The Japanese Experience....Pages 46-48
Metabolic Risks of Diuretic Therapy....Pages 49-53
Sodium and Blood Pressure: A New Zealand Study....Pages 54-57
Blood Pressure in Sodium Fed Humans....Pages 58-61
Adverse Effects of Diuretic Therapy....Pages 62-68
Front Matter....Pages 69-69
Position Paper: Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension....Pages 71-80
Erythrocyte Sodium Extrusion in Primary Hypertension....Pages 81-83
Sodium Countertransport and Co-Transport in Human Red Cell Membranes....Pages 84-86
Cellular Basis of Sodium-Induced Hypertension....Pages 87-90
Alteration of Cell Membrane Control over Intracellular Calcium in Essential Hypertension and in Spontaneously Hypertensive Rats....Pages 91-93
A Circulating Sodium Transport Inhibitor in Essential Hypertension....Pages 94-101
Front Matter....Pages 103-103
Position Paper: Regulation of Blood Pressure by Prostaglandin-Kinin Interactions....Pages 105-113
Prostaglandins in Human Hypertension: Relationships to Renin, Sodium, and Antihypertensive Drug Action....Pages 114-118
Interaction of Kinins and Renal Prostaglandins....Pages 119-121
Front Matter....Pages 123-123
Position Paper: The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-term Blood Pressure Regulation....Pages 125-134
Regulation of Renal Blood Flow by Chloride....Pages 135-138
Action of Angiotensin II on Renal Blood Flow and Urinary Sodium Excretion....Pages 139-140
Neural Regulation of Renal Function....Pages 141-142
Renal Perfusion and Vascular Reactivity in Essential Hypertension....Pages 143-147
Does Hypertension Develop Through Long-term Autoregulation?....Pages 148-156
Front Matter....Pages 157-157
Position Paper: Vasoconstriction and Volume Factors in Renovascular Hypertension....Pages 159-164
Intrarenal Resistance in Experimental Benign and Malignant Hypertension....Pages 165-168
Renal Mechanisms in the Pathogenesis of Essential Hypertension....Pages 169-172
Renal Venous Renin Secretory Patterns Before and After Percutaneous Transluminal Angioplasty: Verification of Analytic Criteria....Pages 173-180
Front Matter....Pages 181-181
Position Paper: The Renin-Angiotensin-Aldosterone System for Blood Pressure Regulation and for Subdividing Patients to Reveal and Analyze Different Forms of Hypertension....Pages 183-194
Artifacts in the Diagnosis of Essential Hypertension....Pages 195-198
Low-Renin Essential Hypertension: Diminution of Aldosterone Suppression?....Pages 199-203
Identifying Renin Participation in Hypertensive Patients....Pages 204-207
Renin-Angiotensin-Aldosterone System in the Maintenance of Blood Pressure....Pages 208-216
Front Matter....Pages 217-217
Position Paper: The Control of Renin Release....Pages 219-227
Humoral Mechanisms of Renin Release....Pages 228-231
Front Matter....Pages 217-217
Intrarenal Renin-Angiotensin-Sodium Interdependent Renal Vasoconstriction Mechanism Controlling Postclamp Renal Artery Pressure and Renin Release in Chronic One-Kidney, One-Clip Goldblatt Hypertensive Dog....Pages 232-235
Renin Responsiveness to Neural and Nonneural-Mediated Stimuli in the Renin Subgroups of Essential Hypertension....Pages 236-239
Alpha- and Beta-Adrenoreceptors and Renin Release....Pages 240-243
Front Matter....Pages 245-245
Position Paper: Extravascular and Plasma Prorenin and Renin....Pages 247-257
Renin Purification....Pages 258-262
High-Molecular-Weight Form of Renal Renin and Renin-Binding Substance in the Dog....Pages 263-264
Brain Renin....Pages 265-267
Role of the Brain Renin-Angiotensin System in Central Mechanisms of Blood Pressure Control....Pages 268-273
Vascular Renin....Pages 274-280
Front Matter....Pages 281-281
Position Paper: The Sympathetic Nervous System and Hypertension....Pages 283-289
Effect of Posture, Isometric Hand-Grip Exercise, and Norepinephrine Infusion in Normal-Renin Hypertensive Patients....Pages 290-296
Interrelationships Between Plasma Norepinephrine and Blood Pressure Response to Norepinephrine in Normotension and Hypertension....Pages 297-300
Central Noradrenergic Mechanisms in Hypertension and in Postural Hypotension....Pages 301-305
Use of Circulating Catecholamines for the Detection of Autonomic Abnormalities in Human Hypertension....Pages 306-311
Sympathetic Nervous System, Catecholamine Receptors, and Hypertension....Pages 312-315
Changing Role of Beta- and Alpha-Adrenoreceptor-Mediated Cardiovascular Responses in the Transition from High-Cardiac Output into a High-Peripheral Resistance Phase in Essential Hypertension....Pages 316-326
Front Matter....Pages 327-327
Position Paper: The Brain, Centrally Acting Drugs, the Renin System and Blood Pressure Regulation....Pages 329-336
Sodium and Central Nervous System Mechanisms....Pages 337-340
Experimental Evidence in Support of a Central Neural Imbalance Hypothesis of Hypertension....Pages 341-343
Brain Centers for Pharmacologic Control of the Cadiovascular System....Pages 344-347
Front Matter....Pages 327-327
Central and Peripheral Alpha-Adrenoreceptors and the Actions of Clonidine and Methyldopa....Pages 348-352
Front Matter....Pages 353-353
Position Paper: Hypertension Mechanisms in Experimental Animals and Their Relevance to Humans....Pages 355-366
Neurogenic Elements in Rat Primary Hypertension: Differences Between Spontaneously Hypertensive Rats and the Milan Hypertensive Strain....Pages 367-369
Hypertension and Stroke Mechanisms in Spontaneously Hypertensive Rats....Pages 370-372
Pressor and Volume Effects of Vasopressin....Pages 373-380
Front Matter....Pages 381-381
Position Paper: Hypertension, Vasoconstriction, and the Causation of Cardiovascular Injury: The Renin-Sodium Profile as an Indicator of Risk....Pages 383-395
Vascular Compliance and Pulsatile Flow as Determinants of Vascular Injury....Pages 396-400
Endothelial Injury in Hypertension....Pages 401-403
Hypertension-Induced Vascular Fibrosis and its Reversal by Antihypertensive Drugs....Pages 404-411
Hypertension, Vasopressors, and Susceptibility to Vascular Injury: Experimental and Clinical Studies....Pages 412-419
Front Matter....Pages 421-421
Position Paper: Antihypertensive Actions of Beta-Blockers....Pages 423-435
Comparison of a Beta-Blocker and Converting Enzyme Inhibitor in Two Types of Experimental Hypertension....Pages 436-439
Pressor Effect of Beta-Adrenergic Blockade and Angiotensin II in Nephrectomized Rats....Pages 440-444
Catecholamines as Predictors of Drug Response....Pages 445-449
Renin Activity and the Response to Beta-Blockade....Pages 450-453
Total Peripheral Resistance and Beta-Adrenergic Blockade....Pages 454-458
Mechanisms of Beta-Blockade Hypotension....Pages 459-461
Aldosterone: Possible Roles in Sustaining Essential Hypertension and in Determining Response to Antihypertensive Treatment....Pages 462-469
Front Matter....Pages 471-471
Position Paper: Differential Features of Beta- Adrenoreceptor Blocking Drugs for Therapy....Pages 473-481
Front Matter....Pages 483-483
Postinfarction Intervention Studies with Propranolol and Atenolol: Problems in Design and Interpretation....Pages 485-489
Front Matter....Pages 483-483
Secondary Prevention of Myocardial Infarction with Beta-Adrenoreceptor Blocking Drugs—Alprenolol, Practolol, and Oxprenolol....Pages 490-494
The Role of Beta-Blockers in Cardioprotection....Pages 495-499
Front Matter....Pages 501-501
Position Paper: Angiotensin-Converting Enzyme Blockade as a Therapeutic Modality....Pages 503-516
Immediate and Delayed Antihypertensive Effects of Angiotensin-Converting Enzyme Inhibition with Captopril....Pages 517-521
Late Resistance to Captopril....Pages 522-526
Converting Enzyme Inhibitors in the Treatment of Heart Failure....Pages 527-528
Summary of Worldwide Captopril Experience in Patients with Severe Treatment-Resistant Hypertension....Pages 529-531
The Effect of Captopril on Urinary Kinins and Urinary Kallikrein Activity in Essential Hypertension....Pages 532-537
Front Matter....Pages 539-539
Position Paper: Physiologic Effects and Diagnostic Relevance of Acute Converting Enzyme Blockade....Pages 541-550
Does Captopril Decrease Blood Pressure by Mechanisms Other Than Inhibition of Angiotensin II Formation?....Pages 551-555
The Effects of Intravenous Angiotensin II on the Cardiac Baroreceptor Reflex....Pages 556-558
Captopril in Angiotensin-Salt Hypertension: A Possible Linkage between Angiotensin, Salt, Vascular Disease, and Renomedullary Interstitial Cells....Pages 559-566
Effect of Converting Enzyme Inhibition with Teprotide on Hemodynamics and Cardiovascular Reflexes in Normotensive Subjects....Pages 567-580
Front Matter....Pages 581-581
Position Paper: New Approaches to Renin System Blockade....Pages 583-591
Studies on Experimental Hypertension Using Blockers of Renin, Converting Enzyme, and Angiotensin II....Pages 592-594
Active-Site Specific Inhibitors of Angiotensin-Converting Enzyme....Pages 595-597
Regulation and Properties of Adrenal and Vascular AII Receptors....Pages 598-603
Epilogue: After Dinner Science and Friendship....Pages 604-615
Back Matter....Pages 617-628