Frontiers in Cerebral Vascular Biology: Transport and Its Regulation

Front Matter....Pages i-x
Front Matter....Pages 1-1
Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain....Pages 3-7
Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats....Pages 9-12
Glucose Transporter (Glut1) Expression by Canine Brain Microvessel Endothelial Cells in Culture: An Immunocytochemical Study....Pages 13-18
Application of Novel PCR Strategies to Amplify and Sequence Glucose Transporters in Canine Brain....Pages 19-24
Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man....Pages 25-27
Rat Brain Glucose Concentration and Transport Kinetics Determined with 13 C Nuclear Magnetic Resonance Spectroscopy....Pages 29-34
Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13 C Nuclear Magnetic Resonance....Pages 35-40
Front Matter....Pages 41-41
Potassium Transport at the Blood-Brain and Blood-CSF Barriers....Pages 43-54
Expression of Na, K-ATPase at the Blood-Brain Interface....Pages 55-60
Effects of Protein Kinase C Agonists on Na, K-ATPase Activity in Rat Brain Microvessels....Pages 61-64
Brain Volume Regulation During Development: The Role of Blood-Brain Barrier Potassium Transport....Pages 65-69
The Transendothelial DC Potential of Rat Blood-Brain Barrier Vessels in Situ....Pages 71-74
Phosphate Transport in Capillaries of the Blood-Brain Barrier....Pages 75-80
Front Matter....Pages 81-81
Drug Delivery to Brain and the Role of Carrier-Mediated Transport....Pages 83-93
Vasopressin Modulates the Blood-Brain Transfer of Amino Acids-Studies with [ 11 C]Methionine in Dogs....Pages 95-100
Amino Acid Transport at the Blood-Nerve Barrier of the Rat Peripheral Nerve....Pages 101-106
Effect of Intra-Uterine Growth Retardation on Cerebral Amino Acid Transport from Birth to Adulthood....Pages 107-111
Drug Transfer Across the Blood-Brain Barrier: Comparison of in Vitro and in Vivo Models....Pages 113-115
Differential Brain Penetration of Cerebroprotective Drugs....Pages 117-120
P-Glycoprotein is Strongly Expressed in Brain Capillaries....Pages 121-125
Front Matter....Pages 127-127
Transport of Proteins Across the Blood-Brain Barrier via the Transferrin Receptor....Pages 129-136
Endothelial Cell Biology and the Enigma of Transcytosis Through the Blood-Brain Barrier....Pages 137-141
Blood-Brain Transport of Vasopressin....Pages 143-147
Cerebral Pericytes — A Second Line of Defense in Controlling Blood-Brain Barrier Peptide Metabolism....Pages 149-152
Front Matter....Pages 153-153
The Role of Second Messenger Molecules in the Regulation of Permeability in the Cerebral Endothelial Cells....Pages 155-164
Peptidergic Induction of Endothelin 1 and Prostanoid Secretion in Human Cerebromicrovascular Endothelium....Pages 165-170
Endothelin-1 Binding to Human Brain Microvascular and Capillary Endothelium: Membranes vs. Intact Cells....Pages 171-176
Possible Involvement of C-Kinase in Occurrence of Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage....Pages 177-182
A Novel Gene Family May Encode Endothelial Cell Specific Adhesion-Like Molecules: An Extracellular Loop-Repeat-Loop (LRL) Motif and Cytoplasmic Tyrosine Kinase Domains....Pages 183-185
Front Matter....Pages 187-187
Plasminogen Activation and Astroglial-Induced Neural Microvessel Morphogenesis....Pages 189-199
Immortalized Rat Brain Microvessel Endothelial Cells: I - Expression of Blood-Brain Barrier Markers During Angiogenesis....Pages 201-204
Immortalized Rat Brain Microvessel Endothelial Cells: II-Pharmacological Characterization....Pages 205-210
Expression of the HT7 Gene in Blood-Brain Barrier....Pages 211-215
Astrocytes Secrete a Factor Inducing the Expression of HT7-Protein and Neurothelin in Endothelial Cells of Chorioallantoic Vessels....Pages 217-221
Chorioallantoic Membrane (CAM) Vessels do not Respond to Blood-Brain Barrier (BBB) Induction....Pages 223-228
Cerebral Endothelium and Astrocytes Cooperate in Supplying Docosahexaenoic Acid to Neurons....Pages 229-233
Front Matter....Pages 235-235
Effect of Cytokines on ICAM Expression and T Cell Adhesion to Cerebrovascular Endothelial Cells....Pages 237-242
Expression of Endothelial Cell Activation Antigens in Microvessels from Patients with Multiple Sclerosis....Pages 243-248
Generation of an Anti-Mouse Brain Endothelial Cell Monoclonal Antibody that Recognizes 84-110 kDa and 36 kDa Determinants that are Upregulated by Cytokines....Pages 249-254
Front Matter....Pages 255-255
The Use of Intracerebral Microdialysis to Study Blood-Brain Barrier Transport in Health, After Modification and in Disease....Pages 257-262
Front Matter....Pages 255-255
Cerebral Endothelial Mechanisms in Increased Permeability in Chronic Hypertension....Pages 263-266
Altered Fatty Acid Composition of Ethanolamine Phosphoglyceride in Brain Microvessels from Senescent Mouse....Pages 267-271
Preirradiation Osmotic Blood-Brain Barrier Disruption Plus Combination Chemotherapy in Gliomas: Quantitation of Tumor Response to Assess Chemosensitivity....Pages 273-284
The Uptake of Thyroxine by the Isolated Perfused Choroid Plexus of the Sheep....Pages 285-288
Back Matter....Pages 289-295