From Gene to Protein: Information Transfer in Normal and Abnormal Cells

Content: 
MIAMI WINTER SYMPOSIA-VOLUME 16, Page ii
Front Matter, Page iii
Copyright, Page iv
SPEAKERS, CHAIRMEN, AND DISCUSSANTS, Pages xix-xxi
PREFACE, Pages xxiii-xxiv, Keith Brew, Harvey Faber, Thomas R. Russell, Julius Schultz
HOW TO LIVE WITH A GOLDEN HELIX, Pages 1-13, Francis Crick
THE OVOMUCOID GENE ORGANIZATION, STRUCTURE AND REGULATION, Pages 15-53, Bert W. O\'Malley, Joseph P. Stein, Savio L.C. Woo, James F. Catterall, Ming-Jer Tsai, Anthony R. Means
STRUCTURAL ORGANIZATION AND EXPRESSION OF OVALBUMIN AND RELATED CHICKEN GENES, Pages 55-81, P. Chambon, C. Benoist, R. Breathnach, M. Cochet, F. Gannon, P. Gerlinger, A. Krust, M. LeMeur, J.P. LePennec, J.L. Mandel, K. O\'Hare, F. Perrin
AN ENDONUCLEASE-SENSITIVE REGION IN SIMIAN VIRUS 40 CHROMATIN, Pages 83-98, Walter A. Scott, Dianne J. Wigmore, Richard W. Eaton
EXPRESSION OF CLONED VIRAL AND CHROMOSOMAL PLASMID-LINKED DNA IN COGNATE HOST CELLS, Pages 99-132, Charles WEISSMANN, Ned MANTEI, Werner BOLL, Robert F. WEAVER, Tadatsugu TANIGUCHI, Albert VAN OOYEN, Johan VAN DEN BERG, Neil WILKIE, Barklie CLEMENTS, Mike FRIED, Kenneth MURRAY
THE ARRANGEMENT, REARRANGEMENT AND ORIGIN OF IMMUNOGLOBULIN GENES, Pages 133-147, Philip Leder, Jonathan G. Seidman, Edward Max, Yutaka Nishioka, Aya Leder, Barbara Norman, Marion Nau
THE STRUCTURE AND EXPRESSION OF NORMAL AND ABNORMAL GLOBIN GENES, Pages 149-165, R.A. Flavell, G.C. Grosveld, F.G. Grosveld, R. Bernards, J.M. Kooter, E. De Boer, P.F.R. Little
GENOMIC CLONES FROM UNFRACTIONATED DNA, Pages 167-186, O. Smithies, J.L. Slightom, P.W. Tucker, F.R. Blattner
THE PROCESSING OF MESSENGER RNA AND THE DETERMINATION OF ITS RELATIVE ABUNDANCE, Pages 187-206, R.P. Perry, U. Schibler, O. Meyuhas
STEPS IN PROCESSING OF mRNA: IMPLICATIONS FOR GENE REGULATION, Pages 207-228, J.E. Darnell Jr.
5′-CAPPING AND EUKARYOTIC mRNA FUNCTION, Pages 229-243, Aaron J. Shatkin, Nahum Sonenberg, Yasuhiro Furuichi
SPLICE PATTERNS OF ADENOVIRUS AND ADENOVIRUS-SV40 MOSAIC RNA\'S, Pages 245-259, Heiner Westphal, Geoffrey R. Kitchingman, Sing-Ping Lai, Charles Lawrence, Tony Hunter, Gernot Walter
PROCESSING OF BACTERIOPHAGE T7 RNAs BY RNase III, Pages 261-269, F. William Studier, John J. Dunn, Elizabeth Buzash-Pollert
REGULATION OF PROMOTER SELECTION BY RNA POLYMERASES, Pages 271-295, A.A. TRAVERS, R. BUCKLAND, P.G. DEBENHAM
SYNTHESIS AND MATURATION OF TRANSMEMBRANE VIRAL GLYCOPROTEINS, Pages 297-320, Harvey F. Lodish, Dyann Wirth, Mary Porter
THE CONTROL OF PROTEIN SYNTHESIS IN RABBIT RETICULOCYTE LYSATES, Pages 321-346, Tim Hunt
DETERMINANTS IN PROTEIN TOPOLOGY, Pages 347-360, Gunter Blobel
PRECURSORS IN THE BIOSYNTHESIS OF INSULIN AND OTHER PEPTIDE HORMONES, Pages 361-378, Shu J. Chan, Christoph Patzelt, John R. Duguid, Paul Quinn, Allen Labrecque, Barbara Noyes, Pamela Keim, Robert L. Heinrikson, Donald F. Steiner
BIOSYNTHESIS AND PROCESSING OF GLYCOPROTEINS, Pages 379-406, E.C. HEATH, S.A. BRINKLEY, R.C. DAS, T.H. HAUGEN
THE ENZYMATIC CONVERSION OF MEMBRANE AND SECRETORY PROTEINS TO GLYCOPROTEINS, Pages 407-423, William J. Lennarz
OLIGOSACCHARIDE PROCESSING DURING GLYCOPROTEIN BIOSYNTHESIS, Pages 425-432, Ira Tabas, Ellen Li, Mark Michael, Stuart Kornfeld
STRUCTURAL BASIS OF THE REGULATION OF GALACTOSYLTRANSFERASE, Pages 433-447, Keith Brew, Richard H. Richardson, Sudhir K. Sinha
SPECIFICITY CONSIDERATIONS RELEVANT TO PROTEIN KINASE ACTIVATION AND FUNCTION, Pages 449-461, Tung-Shiuh Huang, James R. Feramisco, David B. Glass, Edwin G. Krebs
THE ROLE OF PROTEIN PHOSPHORYLATION IN THE COORDINATED CONTROL OF INTERMEDIARY METABOLISM, Pages 463-481, P. Cohen, N. Embi, G. Foulkes, G. Hardie, G. Nimmo, D. Hylatt, S. Shenolikar
PROTEIN PHOSPHATASE C: PROPERTIES, SPECIFICITY AND STRUCTURAL RELATIONSHIP TO A LARGER HOLOENZYME, Pages 483-499, Ernest Y.C. Lee, James H. Aylward, Ronald L. Mellgren, S. Derek Killilea
REGULATION OF PYRUVATE DEHYDROGENASE BY PHOSPHORYLATION/DEPHOSPHORYLATION, Pages 501-520, Philip J. Randle, Nancy J. Hutson, Alan L. Kerbey, Peter H. Sugden
ALLOSTERIC CONTROL OF E. COLI GLUTAMINE SYNTHETASE IS MEDIATED BY A BICYCLIC NUCLEOTIDYLATION CASCADE SYSTEM, Pages 521-544, E.R. Stadtman, P.B. Chock, S.G. Rhee
POLY(ADP-RIBOSE) AND ADP-RIBOSYLATION OF PROTEINS, Pages 545-566, O. Hayaishi, K. Ueda, M. Kawaichi, N. Ogata, J. Oka, K. Ikai, S. Ito, Y. Shizuta, H. Kim, H. Okayama
IDENTIFICATION OF TWO COLLAGEN RNAS LARGER THAN α1 AND α2 COLLAGEN MRNAS WHICH ARE DECREASED IN TRANSFORMED CELLS, Page 567, Sherrill L. Adams, V. Enrico Avvedimento, Mark E. Sobel, Tadashi Yamamoto, Benoit de Crombrugghe, Ira Pastan, James C. Alwine
PROCESSING OF RNA IN BACTERIA, Page 568, David Apirion, Basanta K. Ghora, Greg Plautz, Tapan K. Misra, Peter Gegenheimer
THE PROTEIN MOIETIES OF THE NON-POLYSOMAL CYTOPLASMIC (FREE) mRNP COMPLEXES OF EMBRYONIC CHICKEN MUSCLE:, Page 569, J. Bag, B.H. Sells
COMPLEX OLIGOSACCHARIDES ASSEMBLED ON LIPID INTERMEDIATES: STUDIES WITH UDP-N-ACETYLGLUCOSAMINE AND GDP-MANNOSE, Page 570, David S. Bailey, Mathias Dürr, Gordon Maclachlan
IS THERE A DIFFERENT MODE OF DNA SYNTHESIS IN NORMAL AND TRANSFORMED HUMAN DIPLOID FIBROBLASTS?, Page 571, David E. Berry, James W. Rawles, James M. Collins
A study of the DNA region coding for initiation of precursor rRNA transcription in Lytechinus variegatus., Page 572, D. Bieber, N. Blin, D.W. Stafford
A LECTIN RESISTANT VARIANT OF MOUSE FIBROBLASTS WITH ALTERED CELL SURFACE GALACTOSE, Page 573, D.A. Blake, W.S. Stanley, B.P. Peters, E.H.Y. Chu, I.J. Goldstein
ALTERATIONS IN THE RATE OF PROTEIN SYNTHESIS OF POLYSOMES EXTRACTED FROM FIBROBLASTS OF PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY AND CARRIERS OF THE DISEASE, Page 574, Léa Brakier-Gingras, Marie Boulé, Michel Vanasse
BIOSYNTHESIS OF THE SMALL NUCLEAR RNAs IN A CELL-FREE SYSTEM FROM MOUSE MYELOMA CELLS, Page 575, Anne Brown, Chi-Jiunn Pan, William F. Marzluff
A SHARED CONTROL MECHANISM FOR REGULATION OF ADENOVIRUS AND SV40 GENE EXPRESSION, Page 576, Rabecca Blanton, Timothy Carter, David Cosvin
IN VITRO SYNTHESIS OF VIRUS-SPECIFIC RNA USING TRANSCRIPTIONAL COMPLEX ISOLATED FROM ADENOVIRUS-INFECTED CELLS, Page 577, N.K. Chatterjee, M.H. Sarma
GENE EXPRESSION OF MAMMALIAN LENS TISSUE: COEXISTENCE AND PROPERTIES OF POLY(A)-CONTAINING AND POLY(A)-LACKING 10S and 14S mRNA SPECIES, Page 578, John H. Chen
GENE EXPRESSION OF MAMMALIAN LENS TISSUE: IS LENS mRNA BICISTRONIC?, Page 579, John H. Chen
THE EXPRESSION OF α-FETOPROTEIN GENE IN NORMAL AND NEOPLASTIC RAT LIVER, Page 580, J.F. Chiu, L. Belanger, P. Commer, C. Schwartz
NUCLEAR PHOSPHOPROTEIN PHOSPHATASE FROM CALF LIVER, Page 581, Ming W. Chou, Eng L. Tan, Chung S. Yang
CHEMICALLY INDUCED GENE EXPRESSION: THE ROLE OF HISTONE HYPER-ACETYLATION IN TRANSFORMATION BY SV40 MINICHROMATIN, Page 582, Bennett N. Cohen, Thomas E. Wagner
TRANSCRIPTION OF THE HISTONE mRNA PRECURSOR DURING THE CELL CYCLE, Page 583, Dave Cooper, Chi-Jiunn Pan, William F. Marzluff
CHARACTERIZATION OF A CYTOPASMIC POLY(A).PROTEIN COMPLEX: END-PRODUCT OR BY-PRODUCT OF MESSENGER RNA METABOLISM?, Page 584, Peter L. Davies
FACTORS WHICH INFLUENCE THE Nα-ACETYLATION OF ACTH AND FRAGMENTS OF ACTH, Page 585, Jack E. Dixon, Terry A. Woodford
INSTABILITY OF HIGHER PLANT CHROMOSOMAL DNA MOLECULARLY CLONED IN E. COLI VIA RECOMBINANT PLASMIDS, Page 586, Virginia K. Eckenrode, Harald Friedrich, Ron T. Nagao, Sidney R. Kushner, Richard B. Meagher
TRANSLATION OF ENDOGENOUS NON-IgG and IgG MESSENGER RNA IN HUMAN LEUKEMIC PLASMA CELLS AFTER TREATMENT WITH SEVERAL ALKYLATING AGENTS, Page 587, B. Emmerich, R. Maurer, G. Schmidt, J. Rastetter
THE IN SITU PHOSPHORYLATION OF THE α-SUBUNIT OF eIF-2 IN RETICULOCYTE LYSATES INHIBITED BY HEME DEFICIENCY, dsRNA, GSSG, OR THE HEME-REGULATED INHIBITOR, Page 588, Vivian Ernst, Daniel Levin, Irving M. London
PURIFICATION OF ARGINYL- AND LYSYL-tRNA SYNTHETASES FROM RAT LIVER: EVIDENCE OF GLYCOPROTEINS, Page 589, Raymant L. Glinski Jr., Philip C. Gainey, Thomas P. Mawhinney, Richard H. Hilderman
MAMMALIAN CELL NUCLEAR RNA LIGASE ACTIVITY, Page 590, Norma Ornstein Goldstein
MULTIPLE FORMS OF α2u GLOBULIN IN THE RAT STUDIED IN VIVO AND IN PRIMARY CULTURES OF ADULT HEPATOCYTES, Page 591, Laura Haars, Henry Pitot
BIOSYNTHESIS OF LYSOSOMAL ENZYMES IN DIPLOID HUMAN FIBROBLASTS, Page 592, Andrej Hasilik, Elizabeth F. Neufeld
ISOLATION AND PARTIAL CHARACTERIZATION OF β-LIKE GLOBIN GENES FROM TOTAL GENOMIC GOAT DNA, Page 593, Joel R. Haynes, Paul Rosteck Jr., Jeffrey Robbins, Greg Freyer, Douglas J. Burks, Michael Cleary, Jerry B. Lingrel
REGULATION OF METALLOTHIONEIN SYNTHESIS IN CULTURED MAMMALIAN CELLS: INDUCTION, DEINDUCTION, AND SUPERINDUCTION, Page 594, C.E. Hildebrand, M.D. Enger
A CLASS OF HIGHLY REPEATED DNA SEQUENCES UBIQUITOUS TO THE HUMAN GENOME, Page 595, Catherine M. Houck, Frank P. Rinehart, Carl W. Schmid
REGULATION OF HMG-CoA REDUCTASE AND REDUCTASE KINASE BY REVERSIBLE PHOSPHORYLATION, Page 596, T.S. Ingebritsen, R.A. Parker, D.M. Gibson
STRUCTURE AND EXPRESSION OF THE ALPHA FETOPROTEIN GENE, Page 597, M.A. Innis, D.L. Miller
CONTROL OF eIF-2 PHOSPHORYLATION IN RABBIT RETICULOCYTE LYSATE, Page 598, Rosemary Jagus, Brian Safer
ORGANIZATION OF IMMUNOGLOBULIN KAPPA LIGHT CHAIN GENES IN GERM LINE AND SOMATIC CELLS, Page 599, Rolf Joho, Irving Weissman, Philip Early, Leroy Hood
CLONING OF FRAGMENTS OF THE SEA URCHIN HISTONE GENE CLUSTER WITH SV40 DNA AS A VECTOR, Page 600, John S. Kaptein, George C. Fareed
Regulation by Metabolites of Inactivating and Additional Phosphorylation Reactions in the Pig Heart Pyruvate Dehydrogenase Complex, Page 601, Alan L. Kerbey, Peter H. Sugden, Philip J. Randle
CYCLIC AMP STIMULATION OF RIBOSOMAL PHOSPHOPROTEIN PHOSPHATASE ACTIVITY, Page 602, Robert Kisilevsky, Margaret Treloar
UNUSUAL GENOME ORGANIZATION OF NEUROSPORA CRASSA, Page 603, Robb Krumlauf, George Marzluf
CLONING AND CHARACTERIZATION OF ALLELES OF THE NATURAL OVALBUMIN GENE CREATED BY MUTATIONS IN THE INTERVENING SEQUENCES, Page 604, Eugene C. Lai, Savio L.C. Woo, Achilles Dugaiczyk, Donald A. Colbert, Bert W. O\'Malley
DIFFERENTIAL INFLUENCE OF mRNA CAP METABOLISM ON PROTEIN SYNTHESIS IN DIFFERENTIATING EMBRYONIC CHICK LENS CELLS, Page 605, Gene C. Lavers, Gregory Gang, E.M. Ciccone
MOLECULAR STUDIES OF RETRODIFFERENTIATION PHENOMENA IN PROLIFERATION-COMPETENT ADULT HEPATOCYTE CULTURES, Page 606, H. Leffert, J. Bonner, J. Brown, T. Moran, J. Sala-Trepat, S. Sell, H. Skelly, K. Thomas
ROLE OF PROTEIN SYNTHESIS IN THE REPLICATION OF THE “KILLER VIRUS” OF YEAST, Page 607, Michael J. Leibowitz
EFFECTS OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE II FROM RETICULOCYTES AND BOVINE HEART MUSCLE ON PROTEIN PHOSPHORYLATION AND PROTEIN SYNTHESIS IN RETICULOCYTE LYSATES, Page 608, Daniel Levin, Vivian Ernst, Irving M. London
FUNCTIONAL HETEROGENEITY IN THE RNAS OF TYMV VIRIONS, Page 609, D. Lightfoot, R. Clark
SUBCELLULAR DISTRIBUTION OF SV40 T ANTIGEN SPECIES IN VARIOUS CELL LINES, Page 610, Samuel W. Luborsky, K. Chandrasekaran
HORMONAL REGULATION OF PROTEIN BIOSYNTHESIS IN RAT EPIDIDYMAL FAT CELLS: STIMULATION BY INSULIN, INHIBITION BY FASTING, AND PERMISSIVE EFFECTS OF ADRENAL GLUCOCORTICOIDS, Page 611, Robert T. Lyons, Donald A. Young
REVERSAL OF POST TRANSLATIONAL TYROSYLATION OF TUBULIN, Page 612, Todd M. Martensen, Martin Flavin
SALT-DEPENDENT TRANSCRIPTIONAL SPECIFICITY OF T7 RNA POLYMERASE, Page 613, William T. McAllister, Anthony D. Carter
DIFFERENTIAL SENSITIVITY OF INHIBITION OF CYCLIC AMP PHOSPHODIESTERASE IN THE THYMUS DURING MURINE LEUKEMOGENESIS, Page 614, Lawrence A. Menahan
IN VIVO SUBNUCLEAR DISTRIBUTION OF LARGER THAN TETRAMERIC POLYADENOSINE DIPHOSPHORIBOSE IN RAT LIVER, Page 615, Takeyoshi Minaga, Ernest Kun
PROCESSING AND TRANSPORT OF RNA FOLLOWING MITOGENIC STIMULATION OF HUMAN LYMPHOCYTES, Page 616, M.F. Mitchell, E. Bard, J.G. Kaplan
IDENTIFICATION OF DROSOPHILA 2S rRNA AS THE 3′-PART OF 5.8S rRNA, Page 617, George Pavlakis, Regina Wurst, John Vournakis
FACILITATION BY PYRIMIDINE NUCLEOSIDES AND HYPOXANTHINE OF MNNG MUTAGENESIS IN CHINESE HAMSTER CELLS, Page 618, A.R. Peterson, Hazel Peterson, J.R. Landolph, Charles Heidelberger
NONCODING INSERTS IN HEMOGOLOBIN AND SIMIAN VIRUS 40 GENES ARE BOUNDED BY SELF-COMPLEMENTARY REGIONS, Page 619, Manfred Philipp, Robert Bernholc, Avi Rubinsztejn, Darrell Ballinger
A VARIANT OF POLYOMA VIRUS ALTERED IN ITS PROCESSING OF LATE VIRAL RNA, Page 620, B.J. Pomerantz, C.E. Blackburn, E.K. Thomas, V.A. Merchant, J.D. Hare
PROTEASE-MEDIATED MORPHOLOGICAL CHANGES INDUCED BY TREATMENT OF TRANSFORMED CHICK FIBROBLASTS WITH A TUMOR PROMOTER: EVIDENCE FOR DIRECT CATALYTIC INVOLVEMENT OF PLASMINOGEN ACTIVATOR, Page 621, James P. Quigley
RECOVERY OF A TRANSFORMING VIRUS FROM AKR MOUSE TUMOR TISSUE BY DNA TRANSFECTION, Page 622, John M. Rice, Anna D. Barker, Anthony J. Dennis
SYNTHESIS AND POST-TRANSLATIONAL MODIFICATION OF RETROVIRUS PRECURSOR POLYPROTEINS ENCODED BY gag AND env GENES, Page 623, A.M. Schultz, S. Oroszlan
AVIAN MYELOBLASTOSIS VIRUS (AMV) LINEAR DUPLEX DNA: IN VITRO ENZYMATIC SYNTHESIS AND STRUCTURAL ORGANIZATION ANALYSIS, Page 624, Robert A. Schulz, Takis S. Papas, Jack G. Chirikjian
STUDIES ON THE DNA-DIRECTED IN VITRO SYNTHESIS OF BACTERIAL ELONGATION FACTOR TU, Page 625, Tanya Schulz, Carlos Spears, Herbert Weissbach
IN VITRO TRANSCRIPTION OF Ad2 DNA BY EUKARYOTIC RNA POLYMERASES II. I. KINETICS OF FORMATION OF STABLE BINARY COMPLEXES AT SPECIFIC SITES, Page 626, S. Seidman, F. Witney, S. Surzycki
CHARACTERIZATION OF HUMAN FETAL γ GLOBIN DNA, Page 627, Jerry L. Slightom, Philip W. Tucker
PHOSPHORYLATION AND INACTIVATION OF GLYCOGEN SYNTHASE BY A Ca++ CDR-DEPENDENT KINASE, Page 628, Thomas R. Soderling, Ashok Srivastava
A POLYPEPTIDE IN INITIATION FACTOR PREPARATIONS THAT RECOGNIZES THE 5′-TERMINAL CAP IN EUKARYOTIC mRNA, Page 629, Nahum Sonenberg, Aaron J. Shatkin
LOCATION AND SEQUENCE OF A PUTATIVE PROMOTER FOR THE B GENE OF BACTERIOPHAGE S13, Page 630, J.H. Spencer, E. Rassart, K. Harbers
REGULATION OF PROTEIN SYNTHESIS: ROLE OF NAD+ AND SUGAR PHOSPHATES IN LYSED RABBIT RETICULOCYTES, Page 631, R.J. Suhadolnik, J.M. Wu, C.P. Cheung, A. Bruzel, J. Mosca
THE EFFECT OF CORTISOL ON GLUCOCORTICOID “RESISTANT” THYMOCYTES, Page 632, E. Aubrey Thompson Jr.
THE EFFECTS OF STREPTOCOCCUS PNEUMONIAE INFECTION ON HEPATIC MESSENGER RNA PRODUCTION, Page 633, William L. Thompson, Robert W. Wannemacher Jr.
IDENTIFICATION OF PUTATIVE PRECURSORS OF OVALBUMIN AND OVOMUCOID MESSENGER RNAs, Page 634, Ming-Jer Tsai, J.L. Nordstrom, D.R. Roop, B.W. O\'Malley
PURIFICATION OF mRNA GUANYLYL TRANSFERASE FROM HELA CELLS, Page 635, S. Venkatesan, B. Moss
EMERGENCE OF RESISTANCE TO GLUCOCORTICOID HORMONES IN CANCER CELLS: DETECTION OF DIFFERENCES IN PROTEINS SYNTHESIZED BY GLUCOCORTICOID-SENSITIVE AND -RESISTANT MOUSE P1798 LYMPHOSARCOMA CELLS, Page 636, Bruce P. Voris, Mary L. Nicholson, Donald A. Young
COMPLEXITY AND DIVERSITY OF POLYSOMAL AND INFORMOSOMAL mRNA FROM CHINESE HAMSTER CELLS, Page 637, Ronald A. Walters, Paul M. Yandell, M. Duane Enger
CHARACTERIZATION OF A VIRION-ASSOCIATED RNA POLYMERASE FROM KILLER YEAST, Page 638, J. Douglas Welsh, Michael J. Leibowitz
IN VITRO TRANSCRIPTION OF Ad2 DNA BY EUKARYOTIC RNA POLYMERASES II. II. TRANSCRIPTION FROM STABLE BINARY COMPLEXES, Page 639, F. Witney, S. Seidman, S. Surzycki
MOUSE FETAL HEMOGLOBIN SYNTHESIS IN MURINE ERYTHROLEUKEMIC CELLS, Page 640, N.C. Wu, R.M. Zucker
SPECTROSCOPIC PROBES FOR STUDY OF GENE TRANSCRIPTION, Page 641, L.R. Yarbrough, Michael Baughman, Joseph G. Schlageck
POSITIVE TRANSCRIPTIONAL CONTROL OF INDUCIBLE GALACTOSE PATHWAY ENZYMES IN YEAST, Page 642, James G. Yarger, James E. Hopper
LOCALIZATION AND CHARACTERIZATION OF THE 5′ END OF ADENOVIRUS-2 FIBER mRNA, Page 643, B.S. Zain, J. Sambrook, A. Dunn, R.J. Roberts