Free Radicals in Diagnostic Medicine: A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy

Front Matter....Pages i-xvi
Lipid Peroxides and Related Radicals in Clinical Medicine....Pages 1-15
Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis....Pages 17-27
Free Radical Mechanisms for Chromosomal Instability in Bloom’s Syndrome....Pages 29-41
The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds Related to Oxidative Stress as Applied to the Clinical Chemistry Laboratory....Pages 43-58
Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids....Pages 59-71
Free Radicals and Ocular Disease....Pages 73-86
Active Oxygen Mechanisms of UV Inflammation....Pages 87-97
Oxygen-Free Radicals at Myocardial Level: Effects of Ischaemia and Reperfusion....Pages 99-111
Mechanisms of Atherosclerosis: Role of LDL Oxidation....Pages 113-128
Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury....Pages 129-146
Free Radicals in the Pathophysiology of Pulmonary Injury and Disease....Pages 147-163
Lipid Peroxides in Hepatic, Gastrointestinal, and Pancreatic Diseases....Pages 165-169
Reactive Oxygen Molecules in the Kidney....Pages 171-183
Reactive Oxygen Species (ROS) and Reproduction....Pages 185-197
Autoimmune and Inflammatory Diseases....Pages 199-213
Antioxidants and Cancer: Molecular Mechanisms....Pages 215-239
New Directions for Free Radical Cancer Research and Medical Applications....Pages 241-251
Shock and Multiple Organ Failure....Pages 253-268
Role of Nutrients in the Cause and Prevention of Oxygen Radical Pathology....Pages 269-289
Involvement of Free Radical Mechanism in the Toxic Effects of Alcohol: Implications for Fetal Alcohol Syndrome....Pages 291-305
21-Aminosteroids (“Lazaroids”)....Pages 307-312
The Potential of Gliclazide, a Sulphonylurea to Influence the Oxidative Processes within the Pathogenesis of Diabetic Vascular Disease....Pages 313-324
Interactions between Vitamin E, Free Radicals, and Immunity during the Aging Process....Pages 325-333
Vitamins and Carotinoids — A Promising Approach to Reducing the Risk of Coronary Heart Disease, Cancer and Eye Diseases....Pages 335-350
Free Radical Scavenging and Antioxidant Activity of Plant Flavonoids....Pages 351-376
Plasma Clearance and Immunologic Properties of Long-Acting Superoxide Dismutase Prepared Using 35,000 to 120,000 Dalton Poly-Ethylene Glycol....Pages 377-387
Clinical Trials with Dismutec™ (Pegorgotein; Polyethylene Glycol-Conjugated Superoxide Dismutase; PEG-SOD) in the Treatment of Severe Closed Head Injury....Pages 389-400
A New Method for Detecting Lipid Peroxidation by Using Dye Sensitized Chemiluminescence....Pages 401-402
Chemiluminescence and the Challenge to Attomole Detection....Pages 403-403
Evidence Against Malondialdehyde Bound to Cellular Constituents in Phospholipid Peroxidation....Pages 404-406
Evaluation of In Vivo Free Radical Activity during Endotoxic Shock Using Scavengers, Electron Microscopy, Spin Traps, and Electron Paramagnetic Resonance Spectroscopy....Pages 407-409
Involvement of Hydroxyl Radicals in Endotoxin-Evoked Shock....Pages 410-411
The Role of Nitric Oxide in Endotoxin-Elicited Hypodynamic Circulatory Failure....Pages 412-413
 In Vivo Evaluation of the Role of Neutrophil-Derived Free Radicals in the Development of Endotoxic Shock....Pages 414-415
Photosensitized Formation of 8-Hydroxy-2’-Deoxyguanosine by A Cationic meso -Substituted Porphyrin....Pages 416-417
Aging Associated Declines in the Antioxidant Enzymes of Human Testis....Pages 418-419
Lipid Peroxidation in Normal Pregnancy and Preeclampsia....Pages 420-421
Alkylation of Purine Bases by Carbon-Centered Radicals....Pages 422-423
Cytochrome Biochemistry in Sheep Retina Following Exposure to Oxygen....Pages 424-425
Cytochrome Oxidase Activity in the Fetal Sheep Retina....Pages 426-427
Age-Related Phospholipid Hydroperoxide Levels in Gerbil Brain Measured by HPLC-Chemiluminescence Assay and Their Relation to Hydroxyl Radical Stress — Clinical Implications....Pages 428-429
Lipid Peroxidation and Diabetic Complications: Effect of Antioxidant Vitamins C and E....Pages 430-432
Vascular Complications of Patients in Kuwait with Type 2 Diabetes Mellitus (NIDDM) and Elevated Serum Lipid Peroxides....Pages 433-435
Vascular and Cellular Protein Changes Precede Hippocampal Pyramidal Cell Loss Following Global Ischemia in the Rat....Pages 436-438
Dietary Antioxidants and Breast Cancer Risk: Effect Modification by Family History....Pages 439-440
Effect of MAK-4 and MAK-5 on Endothelial Cell and Soyabean Lipoxygenase-Induced LDL Oxidation....Pages 441-443
Prevention of Oxidant Stress by Student Rasayana (SR)....Pages 444-445
Biochemical Changes Induced by Maharishi Amrit Kalash (MAK-4) and MA-208 in Diet-Induced Hypercholesterolemic Rabbits....Pages 446-447
In Vitro Ergothioneine Administration Failed to Protect Isolated Ischaemic and Reperfused Rabbit Heart....Pages 448-449
Pentoxifylline Interferes with Potental Sources of Free Radical Generation during Endotoxemia....Pages 450-451
Back Matter....Pages 453-464