Free Radicals and Aging

Front Matter....Pages i-x
Free radical theory of aging: History....Pages 1-10
Free radical theory of aging: View against the reliability theory....Pages 11-19
The rate of DNA damage and aging....Pages 20-30
Genetic stability and oxidative stress: Common mechanisms in aging and cancer....Pages 31-46
Oxygen-induced mitochondrial damage and aging....Pages 47-57
Instabilities of metabolic regulations in aging....Pages 58-63
Protein modification in aging....Pages 64-72
Mitochondrial production of oxygen free radicals in the heart muscle during the life span of the rat: Peak at middle age....Pages 73-77
Lipofuscinogenesis in a model system of cultured cardiac myocytes....Pages 78-88
Cellular clones and transgenic mice overexpressing copper — zinc superoxide dismutase: Models for the study of free radical metabolism and aging....Pages 89-98
The importance of antioxidant enzymes in cellular aging and degeneration....Pages 99-108
Relationship between antioxidants, lipid peroxidation and aging....Pages 109-123
The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells....Pages 124-135
Effect of aging on glutathione metabolism. Protection by antioxidants....Pages 136-144
Inhibition of LDL oxidation by antioxidants....Pages 145-157
Desialylated low density lipoproteins and atherosclerosis....Pages 158-163
Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro....Pages 164-177
Oxidative damage in Alzheimer’s dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions....Pages 178-189
The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome....Pages 190-198
Free radicals and neurotransmitters in gerbil brain. Influence of age and ischemia reperfusion insult....Pages 199-212
Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid....Pages 342-352
Possible role of free radicals in the chronic inflammation of the gut....Pages 353-358
Free radicals, lipid peroxidation, SOD activity, neurotransmitters and choline acetyltransferase activity in the aged rat brain....Pages 213-218
Evidence for drug metabolism as a source of reactive species in the brain....Pages 219-226
Anticarcinogenic activities of carotenoids in animals and cellular systems....Pages 227-234
Aging and cancer: Plasma antioxidants and lipid peroxidation in young and aged breast cancer patients....Pages 235-246
DNA damage in mammalian cell lines with different antioxidant levels and DNA repair capacities....Pages 247-250
Variable α -tocopherol stimulation and protection of glutathione peroxidase activity in non-transformed and transformed fibroblasts....Pages 251-256
Assessing and counteracting the prooxidant effects of anticancer drugs....Pages 257-265
Effect of photooxidation on the eye lens and role of nutrients in delaying cataract....Pages 266-279
Carotenoids in the retina — A review of their possible role in preventing or limiting damage caused by light and oxygen....Pages 280-298
Oxidative stress in diabetic retina....Pages 299-307
Active oxygen species, articular inflammation and cartilage damage....Pages 308-322
Oxidative damage to collagen....Pages 323-327
Free radicals and aging of the skin....Pages 328-341
Age-related variations of enzymatic defenses against free radicals and peroxides....Pages 359-367
Antioxidant status (selenium, vitamins A and E) and aging....Pages 368-397
Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study....Pages 398-410
Vitamin E requirement in relation to dietary fish oil and oxidative stress in elderly....Pages 411-418
Vitamin C and vitamin E — synergistic interactions in vivo?....Pages 419-422
The threshold of age in exercise and antioxidants action....Pages 423-427
Antioxidant therapy in the aging process....Pages 428-437
Back Matter....Pages 438-443