Excitatory Amino Acids and Epilepsy

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Amygdalohippocampal and Amygdalocortical Projections in the Primate Brain....Pages 3-17
Subcortical Projections from the Amygdaloid Complex....Pages 19-33
Cortical and Subcortical Afferents of the Amygdaloid Complex....Pages 35-52
Putative Amino Acid Transmitters in the Amygdala....Pages 53-66
A Survey of the Anatomy of the Hippocampal Formation, with Emphasis on the Septotemporal Organization of Its Intrinsic and Extrinsic Connections....Pages 67-82
Cytochemical Architecture of the Entorhinal Area....Pages 83-98
Front Matter....Pages 103-103
Neuronal and Glial Pathologies: Morphology and Physiology of Human and Monkey Epileptic Foci....Pages 105-113
Metabolic, Morphologic and Electrophysiologic Profiles of Human Temporal Lobe Foci: An Attempt at Correlation....Pages 115-125
Endogenous Excitotoxins as Possible Mediators of Ischemic and Hypoglycemic Brain Damage....Pages 127-138
Role of the Substantia Nigra in the Kindling Model of Limbic Epilepsy....Pages 139-146
Long Term Sequelae of Parenteral Administration of Kainic Acid....Pages 147-155
Electrophysiology of Epileptic Tissue: What Pathologies are Epileptogenic?....Pages 157-172
Front Matter....Pages 173-173
Pathophysiological Aspects of Blood-Brain Barrier Permeability in Epileptic Seizures....Pages 175-189
Blood-Brain Barrier Permeability to Excitatory Amino Acids....Pages 191-198
Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain?....Pages 199-209
Extravasated Protein as a Cause of Limbic Seizure-Induced Brain Damage: An Evaluation Using Kainic Acid....Pages 211-221
Ultrastructural Analysis of Rat Brain Tissue Following Systemic Kainate Administration....Pages 223-230
Front Matter....Pages 235-235
Anatomical Organization of Excitatory Amino Acid Receptors and Their Properties....Pages 237-252
Homocysteic Acid, an Endogenous Agonist of NMDA-Receptor: Release, Neuroactivity and Localization....Pages 253-262
Excitatory Amino Acid Pathways in the Brain....Pages 263-284
Front Matter....Pages 235-235
Synthesis and Release of Amino Acid Transmitters....Pages 285-293
Na + Fluxes as a Tool to Identify Anticonvulsant Antagonists of Neuroexcitation....Pages 295-301
Involvement of Excitatory Amino Acid Receptors in the Mechanisms Underlying Excitotoxic Phenomena....Pages 303-316
Front Matter....Pages 319-319
Excitatory Amino Acid Antagonists as Novel Anticonvulsants....Pages 321-329
The Hyperexcited Brain: Glutamic Acid Release and Failure of Inhibition....Pages 331-347
Anti-Excitotoxic Actions of Taurine in the Rat Hippocampus Studied in Vivo and in Vitro ....Pages 349-362
Alterations in Extracellular Amino Acids and Ca 2+ Following Excitotoxin Administration and During Status Epilepticus....Pages 363-373
Acidic Peptides in Brain: Do They Act at Putative Glutamatergic Synapses?....Pages 375-384
Front Matter....Pages 389-389
Synaptic Events Underlying Spontaneous and Evoked Paroxysmal Discharges in Hippocampal Neurons....Pages 391-400
Inward Currents in Cat Neocortical Neurons Studied In Vitro ....Pages 401-411
Synchronization of Pyramidal Cell Firing by Ephaptic Currents in Hippocampus in Situ ....Pages 413-423
Excitatory Amino Acids and Regenerative Activity in Cultured Neurons....Pages 425-437
Long-Term Alterations in Amino Acid-Induced Ionic Conductances in Chronic Epilepsy....Pages 439-447
Excitatory Amino Acids and Epilepsy-Induced Changes in Extracellular Space Size....Pages 449-460
Front Matter....Pages 463-463
Evidence for the Activation of the N-Methyl-D-Aspartate Receptor During Epileptiform Discharge....Pages 465-474
Effects of Kainate on CA1 Hippocampal Neurons Recorded in Vitro ....Pages 475-484
Blockade by D-Aminophosphonovalerate or Mg 2+ of Excitatory Amino Acid-Induced Responses on Spinal Motoneurons in Vitro....Pages 485-495
The Membrane Action of Excitatory Amino Acids on Cultured Mouse Spinal Cord Neurons....Pages 497-506
A Patch-Clamp Study of Excitatory Amino Acid Activated Channels....Pages 507-511
Amino Acid Activated Receptor-Channels at Peripheral and Central Synapses....Pages 513-523
Front Matter....Pages 463-463
Expression of Vertebrate Amino Acid Receptors in Xenopus Oocytes....Pages 525-537
Front Matter....Pages 543-543
Transition Metal Ions in Epilepsy: An Overview....Pages 545-555
Zinc-Binding Proteins in the Brain....Pages 557-570
Neurobehavioral, Neuroendocrine and Neurochemical Effects of Zinc Supplementation in Rats....Pages 571-585
Excitatory Amino Acids and Divalent Cations in the Kindling Model of Epilepsy....Pages 587-598
Effect of Zinc on Neuronal Activity in the Rat Forebrain....Pages 599-609
Relationship of Glutamic Acid And Zinc to Kindling of the Rat Amygdala: Afferent Transmitter Systems and Excitability in a Model of Epilepsy....Pages 611-623
Front Matter....Pages 629-629
Inciting Excitotoxic Cytocide Among Central Neurons....Pages 631-645
Selective and Non-Selective Seizure Related Brain Damage Produced by Kainic Acid....Pages 647-657
On the Role of seizure Activity and Endogenous Excitatory Amino Acids in Mediating Seizure-Associated Hippocampal Damage....Pages 659-671
Kainic Acid Seizures and Neuronal Cell Death: Insights from Studies of Selective Lesions and Drugs....Pages 673-686
Glutamate and Anoxic Neuronal Death in Vitro ....Pages 687-695
Quinolinic Acid: A Pathogen in Seizure Disorders?....Pages 697-707
Back Matter....Pages 713-735