Enzymology and Molecular Biology of Carbonyl Metabolism 6

Front Matter....Pages i-xiv
Crystal Structure of a Class 3 Aldehyde Dehydrogenase at 2.6Å Resolution....Pages 1-7
Conserved Residues in the Aldehyde Dehydrogenase Family....Pages 9-13
Class 3 Aldehyde Dehydrogenase....Pages 15-18
Human Corneal and Lens Aldehyde Dehydrogenases....Pages 19-27
Regulation of Rat ALDH-3 by Hepatic Protein Kinases and Glucocorticoids....Pages 29-36
Mouse Dioxin-Inducible Ahd4 Gene....Pages 37-46
Changes in Aldehyde Dehydrogenase Isozymes Expression in Long-Term Cultures of Human Hematopoietic Progenitor Cells....Pages 47-57
Expression of ALDH3 and NMO1 in Human Corneal Epithelial and Breast Adenocarcinoma Cells....Pages 59-68
A Preliminary Report on the Cloning of a Constitutively Expressed Rat Liver Cytosolic ALDH cDNA by PCR....Pages 69-72
Ontogenesis and Expression of ALDH Activity in the Skin and the Eye of the Rat....Pages 73-80
Class 1 and Class 3 Aldehyde Dehydrogenase Levels in the Human Tumor Cell Lines Currently Used by the National Cancer Institute to Screen for Potentially Useful Antitumor Agents....Pages 81-94
Sex Differences in Endogenous Retinoid Release in the Post-Embryonic Spinal Cord of the Western Mosquitofish, Gambusia affinis affinis ....Pages 95-108
Organ Distribution of Aldehyde Dehydrogenase Activity in the Newt....Pages 109-112
In Hepatoma Cell Lines Restored Lipid Peroxidation Affects Cell Viability Inversely to Aldehyde Metabolizing Enzyme Activity....Pages 113-122
Profiles of Hepatic Cellular Protein Adduction by Malondialdehyde and 4-Hydroxynonenal....Pages 123-131
Inhibition of Human Class 3 Aldehyde Dehydrogenase, and Sensitization of Tumor Cells that Express Significant Amounts of this Enzyme to Oxazaphosphorines, by the Naturally Occurring Compound Gossypol....Pages 133-146
Aldehyde Dehydrogenase-Mediated Metabolism of Acetaldehyde and Mafosfamide in Blood of Healthy Subjects and Patients with Malignant Lymphoma....Pages 147-153
Yeast Aldehyde Dehydrogenase Sensitivity to Inhibition by Chlorpropamide Analogues as an Indicator of Human Aldehyde Dehydrogenase Sensitivity to These Agents....Pages 155-169
Laser Light Scattering and Ultracentrifuge Studies on Sheep Liver Cytosolic Aldehyde Dehdyrogenase....Pages 171-179
Subunit Interactions in Mammalian Liver Aldehyde Dehydrogenases....Pages 181-185
Studies on the Dominant Negative Effect of the ALDH2*2 Allele....Pages 187-194
Mutation of the Conserved Amino Acids of Mitochondria Aldehyde Dehydrogenase....Pages 195-200
The Action of Cytosolic Aldehyde Dehydrogenase on Resorufin Acetate....Pages 201-208
Inhibition of and Interaction with Human Recombinant Mitochondrial Aldehyde Dehydrogenase by Methyl Diethylthiocarbamate Sulfoxide....Pages 209-216
Inhibition of Mouse and Human Class 1 Aldehyde Dehydrogenase by 4-(N,N-Dialkylamino)Benzaldehyde Compounds....Pages 217-224
Phenethyl Isothiocyanate as an Inhibitor of Aldehyde Dehydrogenases....Pages 225-232
Effect of Substituted Bromoacetanilides on Cytosolic Aldehyde Dehydrogenase....Pages 233-241
Human Aldehyde Dehydrogenase E3....Pages 243-252
Human Succinic Semialdehyde Dehydrogenase....Pages 253-260
Effects of Glycerol on the Kinetic Properties of Betaine Aldehyde Dehydrogenase....Pages 261-268
Structural and Functional Studies of A NADP + -Specific Aldehyde Dehydrogenase from the Luminescent Marine Bacterium Vibrio harveyi ....Pages 269-275
 Saccharomyces cerevisiae Aldehyde Dehydrogenases....Pages 277-280
Alcohol Dehydrogenase Variability....Pages 281-289
Three-Dimensional Structures of Human Alcohol Dehydrogenase Isoenzymes Reveal the Molecular Basis for their Functional Diversity....Pages 291-302
Mammalian Class II Alcohol Dehydrogenase....Pages 303-311
Activity of Liver Alcohol Dehydrogenases on Steroids....Pages 313-320
Role of Alcohol Dehydrogenases in Steroid and Retinoid Metabolism....Pages 321-329
Mechanistic Enzymology of Liver Alcohol Dehydrogenase....Pages 331-338
Regulation of the Seven Human Alcohol Dehydrogenase Genes....Pages 339-345
Expression, Activities, and Kinetic Mechanism of Human Stomach Alcohol Dehydrogenase....Pages 347-355
Evidence that Class IV Alcohol Dehydrogenase May Function in Embryonic Retinoic Acid Synthesis....Pages 357-364
Expression of Formaldehyde Dehydrogenase and S -Formylglutathione Hydrolase Activities in Different Rat Tissues....Pages 365-371
Formaldehyde Dehydrogenase from Yeast and Plant....Pages 373-381
Human Sorbitol Dehydrogenase — A Secondary Alcohol Dehydrogenase with Distinct Pathophysiological Roles....Pages 383-393
Structural and Mechanistic Aspects of a New Family of Dehydrogenases, the β-Hydroxyacid Dehydrogenases....Pages 395-402
Structure-Function Relationships of SDR Hydroxysteroid Dehydrogenases....Pages 403-415
 P. putida Formaldehyde Dehydrogenase....Pages 417-423
Nicotinoprotein Alcohol/Aldehyde Oxidoreductases....Pages 425-434
Structural Studies of Aldo-Keto Reductase Inhibition....Pages 435-442
Aldehyde Reductase....Pages 443-451
Study of Non-Covalent Enzyme-Inhibitor Complexes of Aldose Reductase by Electrospray Mass Spectrometry....Pages 453-454
Characterization of a Novel Murine Aldo-Keto Reductase....Pages 455-464
A Potential Role for Aldose Reductase in Steroid Metabolism....Pages 465-473
Hydroxysteroid Dehydrogenases....Pages 475-490
Physiological Substrates of Human Aldose and Aldehyde Reductases....Pages 491-497
Aldose Reductase as Dihydrodiol Dehydrogenase....Pages 499-505
Gene Regulation of Aldose Reductase Under Osmotic Stress....Pages 507-514
Characterization of an Element Resembling an Androgen Response Element (are) in the Human Aldose Reductase Promoter....Pages 515-519
Cloning, Sequencing, and Enzymatic Activity of an Inducible Aldo-Keto Reductase from Chinese Hamster Ovary Cells....Pages 521-528
D-Fructose-Mediated Stimulation of Bovine Lens Aldose Reductase Activation by UV-Irradiation....Pages 529-535
Metabolic Inactivation and Efflux of Daunorubicin as Complementary Mechanisms in Tumor Cell Resistance....Pages 537-544
Cloning and Expression of cDNA Encoding Bovine Liver Dihydrodiol Dehydrogenase 3, DD3....Pages 545-553
Site-Directed Mutagenesis of Residues in Coenzyme-Binding Domain and Active Site of Mouse Lung Carbonyl Reductase....Pages 555-561
An Essential Cysteine (CYS-227) in Human Carbonyl Reductase is Involved in Glutathione Binding....Pages 563-568
Carbonyl Reducing 17β-Hydroxysteroid Dehydrogenase from the Filamentous Fungus Cochliobolus lunatus ....Pages 569-577
A Nomenclature System for the Aldo-Keto Reductase Superfamily....Pages 579-589
Back Matter....Pages 591-602