Endotoxin

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Chemical Synthesis of Endotoxin....Pages 3-11
Structural Requirements of Lipid a for Endotoxicity and Other Biological Activities—An Overview....Pages 13-43
Natural Variants of Lipid A....Pages 45-70
Immunochemistry of Lipid A....Pages 71-79
Bacterial Lipopolysaccharides: Relationship of Structure and Conformation to Endotoxic Activity, Serological Specificity and Biological Function....Pages 81-99
Structure-Activity Relationship of Chemically Synthesized Nonreducing Parts of Lipid a Analogs....Pages 101-119
The Chemical Structure of the Lipopolysaccharide of a Rc-Type Mutant of Proteus mirabilis Lacking 4-Amino-4-Deoxy- L Arabinose and Its Susceptibility towards Polymyxin B....Pages 121-126
The Structure of O-Specific Polysaccharide of Proteus vulgaris 019 Lipopolysaccharide....Pages 127-130
Endotoxins of Pseudomonas fluorescens ....Pages 131-135
Cloning and Expression of rfe Gene....Pages 137-139
Cloning and Analysis of rfb Gene Synthesizing the Mannan O Side Chain of Escherichia coli 09 Lipopolysaccharide....Pages 141-145
Front Matter....Pages 147-147
The Activation of C3H/HeJ Cells by Certain Types of Lipopolysaccharides....Pages 149-157
Lipoamino Acids which are Similar to Bacterial Endotoxin in Both Structure and Biological Activity Related to Physiological Function....Pages 159-162
Chemistry and Biology of a Novel Lipid Contaminant of Some Endotoxin Preparations with Selective Cytotoxicity to Transformed Cells....Pages 163-184
Porin as a Component of Yersinia Pseudotuberculosis Endotoxin....Pages 185-187
Lipopolysaccharides of Non-Cholera Vibrios Possessing Common Antigen Factor to 01 Vibrio cholerae ....Pages 189-197
Immunocytochemical Localization of Bacterial Lipopolysaccharide with Colloidal-Gold Probes in Different Target Cells....Pages 199-202
Development of a New Quantitative Method for Detection of Endotoxin by Fluorescence Labeling of 3-Hydroxy Fatty Acid....Pages 203-213
A New Endotoxin-Specific Assay....Pages 215-223
A New Perchloric Acid Treatment of Human Plasma for Detection of Endotoxin by an Endotoxin-Specific Chromogenic Test....Pages 225-229
Front Matter....Pages 231-231
Fluorescent Detection of Lipopolysaccharide Interactions with Model Membranes....Pages 233-245
Interaction of Mg 2+ and Ca 2+ in In Vitro Hexagonal Assembly of R-Form Lipopolysaccharides....Pages 247-255
Biological Activities of Anti-LPS Factor and LPS Binding Peptide from Horseshoe Crab Amoebocytes....Pages 257-271
Primary Structures and Functions of Anti-Lipopolysaccharide Factor and Tachyplesin Peptide Found in Horseshoe Crab Hemocytes....Pages 273-285
Investigation of Endotoxin Binding Cationic Proteins from Granulocytes; Agglutination of Erythrocytes Sensitized with Re-LPS....Pages 287-299
Interaction of Bacterial Endotoxin (LPS) with Fluid Phase and Macrophage Membrane Associated C1q, the FC-Recognizing Component of the Complement System....Pages 301-317
Further Characterization of Monoclonal Antibodies to Lipopolysaccharide of Salmonella Minnesota Strain R595....Pages 319-330
Specificity and Function of Monoclonal Antibodies Reactive with Discrete Structural Elements of Bacterial Lipopolysaccharide....Pages 331-340
Mechanisms of Neutralization of Endotoxin by Monoclonal Antibodies to O and R Determinants of Lipopolysaccharide....Pages 341-344
Front Matter....Pages 345-345
Possible Refractory Site on LPS-Induced Interleukin 1 Production in C3H/HeJ Peritoneal Macrophages....Pages 347-359
The Role of 13-Hydroxylinoleic Acid in the Activation of Macrophages by Lipopolysaccharide....Pages 361-368
Modulation of Interleukin 1 Production by Endotoxin, Pertussis Toxin, and Indomethacin....Pages 369-374
Immunopharmacologic Aspects of Lipopolysaccharide Endotoxin Action with Special Reference to Cyclic Nucleotides....Pages 375-387
Mechanisms of Endotoxin Stimulation of Monocytes in Whole Blood....Pages 389-398
Comparative Study of Lipopolysaccharide-, Lipid IVa-, and Lipid X-Induced Tumor Necrosis Factor Production in Murine Macrophage-Like Cell Lines....Pages 399-402
Lipopolysaccharide-Induced Priming of the Murine Macrophage-Like Cell Line J774A.1 for Enhanced Production of Reactive Oxygen Intermediates is Blocked by Antiserum to Murine Interferon β....Pages 403-406
Lipopolysaccharide-Containing Cytoplasmic Membranes as Immunostimulators of the Peritoneal Macrophages....Pages 407-412
Effects of Lipopolysaccharide or Recombinant Human-Interleukin-1β on Chemiluminescence by Peritoneal Macrophages from Normal and MRL- 1pr / 1pr Mice....Pages 413-415
LPS-Mediated Triggering of T Lymphocytes in Immune Response Against Gram-Negative Bacteria....Pages 417-425
Involvement of I-A-Restricted B-B Cell Interaction in the Polyclonal B Cell Differentiation Induced by Lipopolysaccharide....Pages 427-443
Front Matter....Pages 345-345
Identification and Characterization of Lipopolysaccharide Receptor Molecules on Mammalian Lymphoid Cells....Pages 445-466
Regulatory Mechanism of Expression of LPS Binding Site(S) and Signaling Events by LPS in Macrophages....Pages 467-480
Endotoxin and Kupffer Cells in Liver Disease....Pages 481-495
Front Matter....Pages 497-497
Metabolic Fate of Endotoxin in Rat....Pages 499-509
Bacterial Endotoxin as a Probe to Investigate Viral Induced Immune Deficiencies....Pages 511-523
Immunoadjuvanticity of Endotoxins and Nontoxic Derivatives for Normal and Leukemic Immunocytes....Pages 525-535
Various Aspects of Synergism between Endotoxin and MDPs....Pages 537-547
The Mediation of Endotoxin-Induced Beneficial Effects by Cytokines....Pages 549-556
The Mechanism of Adjuvant Action of Bacterial Lipopolysaccharide (LPS) in Subcutaneous Immunization....Pages 557-559
Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?....Pages 561-566
A Study of the Cellular and Molecular Mediators of the Adjuvant Action of a Nontoxic Monophosphoryl Lipid A....Pages 567-579
Anti-LPS Region Antibody Responses and Cellular Immune Responsiveness in Typhoid Patients....Pages 581-583
Lipopolysaccharide, but Not Lethal Infection, Releases Tumor Necrosis Factor in Mice....Pages 585-588
Biological Properties of Lipopolysaccharides Isolated from Bordetella....Pages 589-591
Alterations of Responses to Bacterial Endotoxin by Bacteroides Fragilis in Vivo and in Vitro....Pages 593-601
Mechanisms of the Lethal Action of Endotoxin and Endotoxin Hypersensitivity....Pages 603-619
Septic Shock in the Elderly....Pages 621-633
Endotoxin-Induced Cytokines in Human Septicemia....Pages 635-640
Lipid a Precursors Protect Against Endotoxin Challenge....Pages 641-652
New Therapeutic Method Against Septic Shock — Removal of Endotoxin Using Extracorporeal Circulation....Pages 653-664
Front Matter....Pages 497-497
Immunotherapy with Bacterial Endotoxins....Pages 665-676
Stimulation of Nonspecific Resistance by Radio-Detoxified Endotoxin....Pages 677-680
Monoclonal Antibody to Lipid a Prevents the Development of Haemodynamic Disorders in Endotoxemia....Pages 681-684
Endotoxin Size in Hemodialysis Solutions: Modifications in Presence of Concentrated Salt Solutions and Bacterial Products....Pages 685-689
Protective Effect of Salmonella Typhimurium Re-LPS Antiserum....Pages 691-701
Back Matter....Pages 703-715