Elastin and Elastic Tissue

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Introduction....Pages 3-6
The Morphogenesis of Elastic Fibers....Pages 7-17
The Elastic System Fibers....Pages 19-30
Ultrastructural Studies of Developing Pulmonary Alveolar Septal Elastin....Pages 31-37
Ultrastructural Changes of Elastic Tissue in Hamster Lung During Elastase-Emphysema....Pages 39-56
Elastic Tissue Histochemistry....Pages 57-60
Conformation of Aortic Elastin Revealed by Scanning Electronmicroscopy of Dissected Surfaces....Pages 61-70
Scanning Electron Microscopy of Purified Elastin with and Without Enzymatic Digestion....Pages 71-96
The Ultrastructure and Mechanics of Elastic Ligaments....Pages 97-103
Recent Observations on the Structure and Composition of Elastin....Pages 105-116
Ultrastructure of Elastin Coacervates....Pages 119-128
General Discussion on Morphology of Elastin and Elastic Tissue....Pages 129-136
Front Matter....Pages 137-137
Introduction....Pages 139-143
Elastase-Like Enzymes in Aortas and Human Breast Carcinomas: Quantitative Variations with Age and Pathology....Pages 145-164
Chymotrypsinogen D, A New Zymogen from Porcine Pancreas with Proelastolytic Activity....Pages 165-175
Photolysis of Desmosine And Isodesmosine by Ultraviolet Light....Pages 177-187
Factors Affecting the Proteolytic Degradation of Elastin....Pages 189-207
Proteolysis of Tropoelastin....Pages 209-216
Elastin Degradation in Human and Experimental Emphysema....Pages 221-231
The Fate of Intratracheal 14 C-Guanidinated Pancreatic Elastase in Hamster Lung....Pages 233-248
Front Matter....Pages 137-137
Comparison of the Elastolytic Effects of Human Leukocyte Elastase and Porcine Pancreatic Elastase....Pages 249-258
General Discussion on Turnover and Elastolysis....Pages 259-261
Front Matter....Pages 263-263
Introduction....Pages 265-265
The Isolation and Amino Acid Sequence of Some Thrombin Produced Porcine Tropoelastin Peptides....Pages 267-276
Primary Structure of Porcine Tropoelastin....Pages 277-284
Some Kinetic Aspects of Crosslink Biosynthesis....Pages 285-290
Evolution of Elastin Structure....Pages 291-312
Role of Crosslinking in Fiber Formation....Pages 313-327
Desmosine Peptides: Amino Acid Sequences and the Role of These Sequences in Crosslink Formation....Pages 329-342
Crosslinking Profiles of Elastin from Anatomically Defined Regions of the Lung....Pages 343-350
A High Molecular Weight Species of Soluble Elastin-Proelastin....Pages 351-369
Front Matter....Pages 371-371
Introduction....Pages 373-374
Studies on the Major Fucosylated Glycoprotein Released into the Medium by Cultured Human Skin Fibroblasts....Pages 375-384
Studies of the Biosynthesis of a Soluble Precursor of Elastin....Pages 385-395
The Biosynthesis of Elastin by an Aortic Medial Cell Culture....Pages 397-412
An Insoluble Intermediate in the Biosynthesis of Elastin and Its Relationship to Tropoelastin....Pages 413-427
Detection and Estimation of Newly Synthesized Soluble Elastin Using a Hydroxyproline Label....Pages 429-442
Is Newly-Secreted Elastin Cleaved to a Smaller Molecule Before Being Incorporated Into Crosslinked Elastin Fibers?....Pages 443-451
Some Investigations of Elastin Biosynthesis In Vitro Using an Immunoprecipitant....Pages 453-459
Arterial Elastin Synthesis in the Growing Chick....Pages 461-475
Front Matter....Pages 371-371
Hypertension in Weanling Rabbits....Pages 477-490
Studies on the Action of Lysyl Oxidase on Soluble Elastin....Pages 491-508
The Existence of Inhibited Lysyl Oxidase and the Presence of Multiple Forms....Pages 509-529
Studies on Lysyl Oxidase of Bovine Ligamentum Nuchae and Bovine Aorta....Pages 531-542
A Critical Role for Copper in Aortic Elastin Structure and Synthesis....Pages 543-559
Front Matter....Pages 561-561
Introduction....Pages 563-565
Isolation of Lung Alveolar Walls....Pages 567-576
Some Observations on Tissue Sampling Lessons from the Arterial Wall....Pages 577-588
Quantitative NH 2 Terminal Evaluation of Elastin as A Measure of Polypeptide Integrity....Pages 589-595
The Kinetics of Elastolysis as A Probe of Elastin....Pages 597-600
Front Matter....Pages 601-601
Introduction....Pages 603-606
The Elasticity in the Presence of Diluents....Pages 607-619
The Role of Hydrophobic Interactions in the Swelling of Elastin....Pages 621-631
The Molecular Conformation of Elastin as Derived from Mechanical Investigations....Pages 633-643
Calorimetric Studies of Elastin Solvation....Pages 645-654
A 13 C Magnetic Resonance Study of Embryonic Chick Aorta....Pages 655-661
Nuclear Spin Relaxation Studies of Elastin, II. A Preliminary Investigation of the Effects of Stretching and Solvent Composition on Proton Transverse Relaxation....Pages 663-678
X-Ray Analysis of Enzymically Purified Elastin from Bovine Ligamentum Nuchae....Pages 679-683
On the Conformation, Coacervation and Function of Polymeric Models of Elastin....Pages 685-714
The Coacervate-Sol Transition Observed with α-Elastin and its N-Formyl O-Methyl Derivative....Pages 715-723
Front Matter....Pages 601-601
General Discussion on Coacervation....Pages 725-726
Evidence that Tropoelastin Exists as a Random Coil....Pages 727-740
Front Matter....Pages 741-741
Introduction....Pages 743-744
General Discussi....Pages 745-757
Back Matter....Pages 759-782