Eicosanoids, Lipid Peroxidation and Cancer

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Thromboxane A 2 and Prostacyclin in Tumorigenesis....Pages 3-10
Tumour Promoters and Prostaglandin Production....Pages 11-21
Eicosanoid Regulation of Macrophage In Vitro Cytostatic Function Towards Tumour Cells....Pages 23-27
Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis....Pages 29-42
Alteration of Arachidonic Acid Metabolism in Rats after Inoculation of Tumour Cells and Their Subcellular Fractions: Role of Mononuclear Phagocytes as a Major Source of Enhanced Prostanoid Synthesis....Pages 43-50
Front Matter....Pages 51-51
The Role of Platelet-Activating Factor and Structurally Related Alkyl Phospholipids in Immune and Cytotoxic Processes....Pages 53-65
Platelet-Activating Factor in Renal Pathophysiology: The Effects of PAF Antagonists....Pages 67-73
Interaction of Macrophages and Mast Cells in the Production of Prostaglandins and Leukotrienes....Pages 75-83
Prostaglandin E 2 and Thromboxane A 2 Production by Human Peritoneal Macrophages: Effect of Mitomycin C, Nitrogen Mustard and Cyclosporin A....Pages 85-89
Uterine Lipoxygenase Pathways....Pages 91-99
Modulation of Ocular Eicosanoid Biosynthesis by Oxidants and Anti-oxidants....Pages 101-114
Endogenous Formation of Leukotriene D 4 During Systematic Anaphylaxis in the Guinea Pig....Pages 115-124
Theoretical Calculations of the Structures of Some Prostaglandins and Inhibitors of Lipoxygenase....Pages 125-134
Front Matter....Pages 135-135
Lipid Peroxidation and Cell Division in Normal and Tumour Tissues....Pages 137-142
The Involvement of Free Radicals and Lipid Peroxidation in Carcinogenesis....Pages 143-151
Diene Conjugation and Peroxidation in Precancer....Pages 153-159
Oxygen Radical Regulation of Vascular Reactivity....Pages 161-167
Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca 2+ and Protein Kinase C....Pages 169-179
Front Matter....Pages 181-181
Biochemistry of Oxidative Stress: Recent Experimental Work....Pages 183-188
Lipid Peroxidation and Irreversible Hepatocyte Damage....Pages 189-193
Front Matter....Pages 181-181
Lipid Peroxidation, Antioxidants and Regenerating Rat Liver....Pages 195-202
Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins....Pages 203-213
Studies on the Oxygen Dependence of Lipid Peroxidation....Pages 215-220
Iron-Induced Lipid Peroxidation and Inhibition of Proliferation in Animal Tumour Cells....Pages 221-226
Ethane and n -Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System....Pages 227-234
The CCl 4 -Induced Increase of Free Arachidonate in Hepatocytes....Pages 235-241
Lipid Peroxidation Products and Carcinogenesis: Preliminary Evidence of n -Alkanal Genotoxicity....Pages 243-251
Detection of 4-Hydroxynonenal and Other Lipid Peroxidation Products in the Liver of Allyl Alcohol-Intoxicated Mice....Pages 253-263
Liver Cell Heterogeneity in Biotransformation of Carcinogenic Polycyclic Hydrocarbons....Pages 265-272
Free Radical Intermediates of Carcinogenic Hydrazines....Pages 273-280
Front Matter....Pages 281-281
Studies on Cancer of the Human Cervix in Relation to Thiol-Groups....Pages 283-290
Microphotometric Determination of Protein Thiols and Disulphides in Tissue Samples from the Human Uterine Cervix and the Skin Reveal a “Field Effect” in the Surroundings of Benign and Malignant Tumours....Pages 291-299
Protein-Thiol Levels in Relation to Deviation from Normality in Rat Liver Cell Lines....Pages 301-314
Computerized Digital Video Microdensitometry Applied to the Quantitation of Intracellular Macromolecules or Their Functional Groups....Pages 315-325
Modulation of Hepatocarcinogenicity of Aflatoxin B 1 by the Chlorinated Insecticide DDT....Pages 327-338
Intratumoral Fibrin Stabilization....Pages 339-349
Back Matter....Pages 351-362