Effects of Nicotine on Biological Systems II

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Current Controversies in Nicotine Research....Pages 3-8
Acute Biological Effects of Nicotine and Its Metabolites....Pages 9-16
Involvement of Nicotine and Its Metabolites in the Pathology of Smoking-Related Diseases: Facts and Hypotheses....Pages 17-25
Front Matter....Pages 27-27
A Cyclophilin-Dependent Mechanism for α 7 Neuronal Nicotinic Acetylcholine Receptor Maturation....Pages 29-35
 α -Bungarotoxin Receptor Subtypes....Pages 37-44
Neuronal Nicotinic Receptor Structure and Function....Pages 45-52
Determinants Regulating Neuronal Nicotinic Receptor Function....Pages 53-59
Expression, Function, and Regulation of Neuronal Acetylcholine Receptors Containing the α7 Gene Product....Pages 61-68
Front Matter....Pages 69-69
Biochemical Measures of Nicotinic Receptor Desensitization....Pages 71-78
The Role of Desensitization in CNS Nicotinic Receptor Function....Pages 79-85
Presynaptic Nicotinic Autoreceptors and Heteroreceptors in the CNS....Pages 87-94
Regulation of Neuronal Nicotinic Receptors in Primary Cultures....Pages 95-100
Conditioned Tolerance to Nicotine in Rats....Pages 101-107
Front Matter....Pages 109-109
Developmental Effects of Nicotine....Pages 111-117
Presynaptic Nicotine-Gated Channels Potentiate Transmission at ACh and Glutamate-Mediated Synapses....Pages 119-125
Electrophysiology of Neuronal Nicotinic Receptors in the CNS....Pages 127-135
Factors Controlling Nicotinic Acetylcholine Receptor Expression on Rat Sympathetic Neurons....Pages 137-143
Growth Related Role for the Nicotinic α -Bungarotoxin Receptor....Pages 145-150
Mechanisms of Nicotine Stimulated Cell Proliferation in Normal and Neoplastic Neuroendocrine Lung Cells....Pages 151-158
Activation of the Hypothalamic-Pituitary-Adrenal Axis by Nicotine: Neurochemical and Neuroanatomical Substrates....Pages 159-166
Front Matter....Pages 109-109
Regulation of Proenkephalin Gene Expression in Bovine Adrenal Medullary Chromaffin Cells by Nicotine....Pages 167-172
Effects of Nicotine on Thromboxane and Leukotriene Synthesis in Cellular Systems....Pages 173-177
Front Matter....Pages 179-179
Smoking-Induced Alterations in Brain Electrical Profiles: Normalization or Enhancement ?....Pages 181-187
Nicotine and Cognitive Effects....Pages 189-194
Evidence that Nicotine is Addictive....Pages 195-202
Self-Administered Nicotine Acts Through the Ventral Tegmental Area: Implications for Drug Reinforcement Mechanisms....Pages 203-209
Desensitisation of the Stimulatory Effects of Nicotine on Dopamine Secretion in the Mesolimbic System of the Rat....Pages 211-217
Nicotine as a Discriminative Stimulus: Individual Variability to Acute Tolerance and the Role of Receptor Desensitization....Pages 219-223
Behavioral and Biochemical Analysis of the Dependence Properties of Nicotine....Pages 225-232
Nicotine Boost Per Cigarette as the Controlling Factor of Intake Regulation by Smokers....Pages 233-238
There is More to Smoking than the CNS Effects of Nicotine....Pages 239-246
Pharmacological Determinants of Cigarette Smoking....Pages 247-256
The Functional Conception of Nicotine Use....Pages 257-264
Nicotine is Addictive: The Issue of Free Choice....Pages 265-272
Differentiating Habits and Addictions: The Evidence That Nicotine is Not ’Addictive’....Pages 273-278
Differences in Response to Nicotine are Determined by Genetic Factors....Pages 279-284
Front Matter....Pages 285-285
Relationship between Smoking, Nicotine and Ulcerative Colitis....Pages 287-291
Transdermal Nicotine in Tourette’s Syndrome....Pages 293-299
Nicotine and Neuropsychiatric Disorders: Schizophrenia....Pages 301-305
Nicotinic Receptors and the Pathophysiology of Schizophrenia....Pages 307-312
Front Matter....Pages 285-285
The Epidemiology of Cigarette Smoking and Parkinson’s Disease....Pages 313-319
Nicotine and Animal Models of Parkinson’s Disease....Pages 321-328
Nicotine Effects on Memory Performance....Pages 329-335
Possible Mechanisms Underlying Beneficial Effects of Nicotine on Cognitive Function....Pages 337-344
Nicotinic Modulation of Cognitive Functioning in Humans....Pages 345-351
Front Matter....Pages 353-353
Distribution of Nicotinic Acetylcholine Receptor Subunit Immunoreactivities on the Surface of Chick Ciliary Ganglion Neurons....Pages 355-361
Autoradiographic Distribution of Nicotinic Receptor Sites Labelled with [ 3 H]Cytisine in the Human Brain....Pages 363-369
Epibatidine....Pages 371-378
Measuring Changes in Mesolimbic Dopamine and Related Substances in Response to Systemic Nicotine Using in Vivo Electrochemistry....Pages 379-384
Effect of Nicotine and Cotinine on NNK Metabolism in Rats....Pages 385-390
The Future of Nicotine-Containing Products....Pages 391-398
Back Matter....Pages 399-407